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Validation of the Chinese Version of the Relevant Outcome Scale for Alzheimer’s Disease (CROSA)

Published online by Cambridge University Press:  24 March 2021

Shuying Zhang Open the ORCID record for Shuying Zhang [Opens in a new window] ,
Jianing Qi ,
Qing Yang  and
Qihao Guo Open the ORCID record for Qihao Guo [Opens in a new window]
Shuying Zhang*
Affiliation:
Tongji University School of Medicine, Tongji University, Shanghai, China
Jianing Qi
Affiliation:
Tongji University School of Medicine, Tongji University, Shanghai, China
Qing Yang
Affiliation:
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China
Qihao Guo*
Affiliation:
Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China
*
Correspondence should be addressed to: Shuying Zhang, Tongji University School of Medicine, Tongji University, 1239 Si Ping Road, Shanghai200092, China. Phone: +86 21 66051211. Email: zhangsy@tongji.edu.cn; Qihao Guo, Department of gerontology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai200233, China. Phone: +86 13 817741448. Email: qhguo@sjtu.edu.cn
Correspondence should be addressed to: Shuying Zhang, Tongji University School of Medicine, Tongji University, 1239 Si Ping Road, Shanghai200092, China. Phone: +86 21 66051211. Email: zhangsy@tongji.edu.cn; Qihao Guo, Department of gerontology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai200233, China. Phone: +86 13 817741448. Email: qhguo@sjtu.edu.cn
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Abstract

Objectives:

To examine the psychometric properties of the Chinese version of the Relevant Outcome Scale for Alzheimer’s disease (CROSA) among persons with AD (PWAD) and their caregivers in China.

Design:

A single-arm, open-label, multi-center study.

Setting:

Two tertiary general hospitals in Shanghai.

Participants:

A total of 336 PWAD and their family caregivers.

Intervention:

The PWAD completed a 12-week treatment with memantine after a baseline assessment.

Measurements:

The CROSA and the Chinese versions of the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale-Cognitive Subscale, the Disability Activity of Dementia, the Neuropsychiatric Inventory Questionnaire, the Zarit Caregiver Burden Interview and the Self-Efficacy Questionnaire for Chinese Family Caregivers.

Results:

The Cronbach’s alpha for the total scale was 0.900, and the intraclass correlation coefficient and Pearson’s correlation coefficient were 0.910 (P < 0.001) and 0.836 (P < 0.001), respectively. Confirmatory factor analysis revealed the two-factor model to be consistent with the original version. For the known-group validity, the total score of the CROSA classified the PWAD into three stages and three MMSE score groups. Moderate to large correlations with the validated scales confirmed the criteria validity of the CROSA, and the convergent validity was confirmed via testing a hypothesized caregiving model; however, only minimal responsiveness was found among the deterioration group after 12 weeks of treatment with memantine.

Conclusions:

The reliability and validity of the CROSA was good or acceptable for use in daily clinical settings. Further studies are needed to examine the psychometric properties of the scale.

Keywords

Alzheimer’s diseasecognitive assessmentneuropsychiatric symptomsscales
Type
Original Research Article
Information
International Psychogeriatrics , Volume 33 , Special Issue 11: Issue Theme: Advances in Assessment and Diagnosis of Dementia , November 2021 , pp. 1193 - 1205
Copyright
© International Psychogeriatric Association 2021

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Footnotes

†

These authors contributed equally to this study.

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