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Association between antipsychotic medication and venous thromboembolism

Published online by Cambridge University Press:  13 June 2014

Santhana Gunasekaran
Santhana Gunasekaran*
Affiliation:
Newton Lodge Regional Secure Unit, Fieldhead Hospital, Wakefield WF1 3SP, England
*
*Correspondence E-mail: san.gunasekaran@gmail.com
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Abstract

Objective: This study aims to identify and review available evidence in the literature to determine the strength of association between antipsychotic medications and thromboembolism as an adverse effect.

Method: Electronic databases were searched for evidence.

Results: A total of 15 case reports, 14 case series, two observational studies and three case-control studies were found in the literature. Two case control studies found significantly increased risk of venous thromboembolism (OR 13.3 and 7.1 respectively). The risk was high for low potency antipsychotics. Studies were critically appraised to determine the strength of evidence.

Conclusion: The studies reviewed indicate a significant association between antipsychotics and venous thromboembolism. Patients using the antipsychotics and those who prescribe them should be aware of this association.

Keywords

Venous thromboembolismAntipsychoticAdverse effect
Type
Reviews
Information
Irish Journal of Psychological Medicine , Volume 27 , Issue 1 , March 2010 , pp. 22 - 26
Copyright
Copyright © Cambridge University Press 2010

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