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Salbutamol inhaler abuse and psychosis

Published online by Cambridge University Press:  13 June 2014

Paul A Cotter
Paul A Cotter*
Affiliation:
Section of Metabolic Studies, Institute of Psychiatry, Denmark Hill, London SE5 8AF, England
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Abstract

A case is described in which a man with asthma and a history of alcohol dependence presented with a paranoid psychosis refractory to standard neuroleptic treatment. Symptomatic improvement was achieved when abuse of salbutamol (Ventolin®) metered dose inhaler was discovered and an alternative β2-agonist delivery system prescribed. A contribution by salbutamol to the psychosis is proposed. It is suggested that increased awareness regarding psychiatric morbidity is needed when metered dose salbutamol inhalers are prescribed.

Keywords

Salbutamolβ2-agonistsMetered dose inhalersAbusePsychosesAffective disorders
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 14 , Issue 2 , June 1997 , pp. 76 - 77
Copyright
Copyright © Cambridge University Press 1997

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References

1.Pratt, HFAbuse of salbutamol inhalers in young people. Clin Allergy 1982; 12: 203–8.CrossRefGoogle ScholarPubMed
2.Brennan, PO. Inhaled salbutamol: a new form of drug abuse? Lancet 1983; ii: 1030–1.CrossRefGoogle Scholar
3.Thompson, PJ, Dhillon, P, Cole, P. Addiction to aerosol treatment: the asthmatic alternative to glue sniffing. BMJ 1983; 287: 1515–6.CrossRefGoogle ScholarPubMed
4.Brennan, PO. Addiction to aerosol treatment. BMJ 1983; 287: 1877.Google Scholar
5.Raine, JM. Addiction to aerosol treatment. BMJ 1984; 288: 241.CrossRefGoogle ScholarPubMed
6.O'Callaghan, C, Milner, AD. Aerosol treatment abuse. Arch Dis Child 1988; 63: 70.CrossRefGoogle ScholarPubMed
7.Wickramasinghe, H, Liebeschuetz, HJ. Addiction to aerosol treatment. BMJ 1983; 287: 1877.CrossRefGoogle Scholar
8.Gluckman, L. Ventolin psychosis. N Z Med J 1974; 80: 411.Google ScholarPubMed
9.Edwards, JG, Holgate, ST. Dependency upon salbutamol inhalers. Br J Psychiatry 1979; 134: 624–6.CrossRefGoogle ScholarPubMed
10.Prasher, VP, Corbett, JA. Aerosol addiction. Br J Psychiatry 1990; 157: 922–4.CrossRefGoogle ScholarPubMed
11.Slessor, IM. Addiction to aerosol treatment. BMJ 1984; 288: 485.CrossRefGoogle ScholarPubMed
12.Bass, M. Sudden sniffling death. JAMA 1970; 212: 2075–9.CrossRefGoogle Scholar
13.Kjelleman, B. Case report: an asthmatic child with a very high consumption of Ventoline respirator solution. Scand J Resp Dis 1977; (suppl 101): 119–21.Google Scholar
14.Waldmeier, PC. Stimulation of central serotonin turnover by beta-adrenoceptor agonists. Naunyn-Schmiedebergs Arch Pharmacol 1981; 317: 115–9.CrossRefGoogle ScholarPubMed
15.Caccia, S, Fong, MH. Kinetics and distribution of the, β-adrenergic agonist salbutamol in rat brain. J Pharm Pharmacol 1983; 36: 200–1.CrossRefGoogle Scholar
16.Frances, H, Peuch, AJ, Chermat, R, Simon, P. Are psycho-pharmacological effects of β-adrenergic stimulants central or peripheral? Pharmacol Res Commun 1979; 11: 273–8.CrossRefGoogle ScholarPubMed
17.Mogilnicka, E. The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats. J Neural Transm Gen Sect 1982; 53: 117–26.CrossRefGoogle ScholarPubMed
18.Borsini, F, Bendotti, C, Thurlby, P, Samanin, R. Evidence that systematically administered salbutamol reduces food intake in rats by acting on central beta-adrenergic sites. Life Sci 1982; 30: 905–11.CrossRefGoogle Scholar
19.Cowen, PJ, Grahame-Smith, DG, Green, AR, Heal, DJ. Adrenoceptors agonists enhance 5-hydroxytryptramine-mediated behavioural responses. Br J Pharmacol 1982; 76: 265–70.CrossRefGoogle ScholarPubMed
20.Frances, H, Simon, P. The effect of a β-agonist on behaviour mediated by 5-HT1A and 5-HT1B receptors. Biol Psychiatry 1986; 21: 1072–5.CrossRefGoogle Scholar
21.Avorn, J, Everitt, DE, Weiss, S. Increased antidepressant use in patients prescribed, β-blockers. JAMA 1986; 255: 357–60.CrossRefGoogle ScholarPubMed
22.Widlocher, D, Lecrubier, Y, Jouvent, R, Puech, AJ, Simon, P. Antidepressant effect of salbutamol. Lancet 1977; ii: 767–8.CrossRefGoogle Scholar
23.Simon, P, Lecrubier, Y, Jouvent, R, Puech, AJ, Allilaire, JF, Widlocher, D. Experimental and clinical evidence of the antidepressant effect of a beta-adrenergic stimulant. Psychol Med 1978; 8: 335–8.CrossRefGoogle ScholarPubMed
24.Lecrubier, Y, Puech, AJ, Jouvent, R, Simon, P, Widlocher, D. A beta-adrenergic stimulant (salbutamol) versus clomipramine in depression: a controlled study. Br J Psychiatry 1980; 136: 354–8.CrossRefGoogle ScholarPubMed
25.Lerer, B, Ebstein, RP, Belmaker, RH. Subsensitivity of human β-adrenergic adenylate cyclase after salbutamol treatment of depression. Psychopharmacology 1981; 75: 169–72.CrossRefGoogle ScholarPubMed
26.Simon, P, Lecrubier, Y, Jouvent, R, Puech, A, Widlocher, D. β-receptor stimulation in the treatment of depression. Adv Biochem Psychopharmacol 1984; 39: 293–300.Google ScholarPubMed
27.Edwards, DJ, Sorisio, DA, Knopf, S. Effects of the β2-adrenoceptor agonist clenbuterol on tyrosine and tryptophan in plasma and brain of the rat. Biochem Pharmacol 1989; 38: 295–301.CrossRefGoogle Scholar
28.Finnegan, KT, Terwilliger, MM, Berger, PA, Hollister, LE, Csernansky, JG. A comparison of the neurochemical and behavioural effects of clenbuterol and desipramine. Eur J Pharmacol 1987; 134: 131–6.CrossRefGoogle ScholarPubMed
29.Jacquot, M, Bottari, R. Manic episode precipitated by oral intake of salbutamol. L'Encephale 1981; 7: 45–9.Google Scholar
30.Ray, I, Evans, CJ. Paranoid psychosis with Ventolin (salbutamol tablets b.p.) Can Psych Ass J 1978; 23(60): 427.Google ScholarPubMed
31.Whitehouse, AM, Novosel, S. Salbutamol psychosis. Biol Psychiatry 1989; 26: 631–3.CrossRefGoogle ScholarPubMed
32.Khanna, PB, Davies, R. Hallucinations associated with administration of salbutamol via nebuliser. Br Med J 1986; 292: 1430.Google Scholar
33.Feline, A, Jouvent, R. Manifestations psychosensorieuse observees chez des psychotiques soumises a des medications β-mimetriques. L'Encephale 1977; 3: 149–58.Google Scholar