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Attention-deficit hyperactivity disorder (ADHD): progress and controversy in diagnosis and treatment

Published online by Cambridge University Press:  19 June 2018

D. M. Foreman*
Affiliation:
Department of Child and Adolescent Psychiatry, PO85, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
S. Timimi
Affiliation:
Lincolnshire Partnership NHS Foundation Trust, Child and Family Services, Horizon Centre, Lincoln, UK
*
*Address for correspondence: D. M. Foreman, Department of Child and Adolescent Psychiatry, PO85, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 16 De Crespigny Park, London, SE5 8AF, UK.(Email: David_Foreman@doctors.net.uk)

Abstract

Knowledge about attention-deficit hyperactivity disorder (ADHD) is rapidly accumulating. Recent advances in diagnosis, genetics, neuroimaging, drug and non-drug treatments are considered, and the results are related to the critical attack on the ADHD diagnosis, which argues it a medicalising social construct, unhelpfully sustaining power relationships. The advances reviewed suggest that, while this attack can be conclusively dismissed as wrong and misleading, the phenomenological definition of ADHD is no longer sufficient for construct validity, though continues to be valuable as a guide for clinicians. The humanising and individualising concerns underlying the attack on the diagnosis could usefully be redirected to improving effective measurement of patient outcomes.

Type
Debates
Copyright
© College of Psychiatrists of Ireland 2017 

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References

Agnew-Blais, JC, Polanczyk, GV, Danese, A, Wertz, J, Moffitt, TE, Arseneault, L (2016). Evaluation of the persistence, remission, and emergence of attention-deficit/hyperactivity disorder in young adulthood. JAMA Psychiatry 73, 713720.Google Scholar
Bai, M, Lazenby, M (2015). A systematic review of associations between spiritual well-being and quality of life at the scale and factor levels in studies among patients with cancer. Journal of Palliative Medicine 18, 286298.Google Scholar
Banaschewski, T, Gerlach, M, Becker, K, Holtmann, M, Döpfner, M, Romanos, M (2016). Trust, but verify. The errors and misinterpretations in the Cochrane analysis by O. J. Storebo and colleagues on the efficacy and safety of methylphenidate for the treatment of children and adolescents with ADHD. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 44, 307314.Google Scholar
Baroni, A, Castellanos, FX (2015). Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of ‘high definition’ neuroimaging. Current Opinion in Neurobiology 30, 18.Google Scholar
Barrett, S (2015). Some notes on ADHD and Peter R. Breggin’s unfair attack on Ritalin (http://www.quackwatch.com/11Ind/breggin.html). Accessed 20 August 2016.Google Scholar
Button, KS, Ioannidis, JPA, Mokrysz, C, Nosek, BA, Flint, J, Robinson, ESJ, Munafò, MR (2013). Power failure: why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience 14, 365376.Google Scholar
Castellanos, FX, Proal, E (2012). Large-scale brain systems in ADHD: beyond the prefrontal-striatal model. Trends in Cognitive Sciences 16, 1726.Google Scholar
Coe, RJ (2002). It’s the effect size, stupid: what effect size is and why it is important (http://www.leeds.ac.uk/educol/documents/00002182.htm). Accessed 7 April 2013.Google Scholar
Conrad, P, Bergey, MR (2014). The impending globalization of ADHD: notes on the expansion and growth of a medicalized disorder. Social Science & Medicine 122, 3143.Google Scholar
Corbetta Lab (2016). Washington University in St. Louis - Medical School - Corbetta Lab (http://www.nil.wustl.edu/labs/corbetta/research_attention_networks.html). Accessed 21 August 2016.Google Scholar
Crosbie, J, Arnold, P, Paterson, A, Swanson, J, Dupuis, A, Li, X, Shan, J, Goodale, T, Tam, C, Strug, LJ, Schachar, RJ (2013). Response inhibition and ADHD traits: correlates and heritability in a community sample. Journal of Abnormal Child Psychology 41, 497507.Google Scholar
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet 381, 13711379.Google Scholar
Danckaerts, M, Sonuga-Barke, EJS, Banaschewski, T, Buitelaar, J, Döpfner, M, Hollis, C, Santosh, P, Rothenberger, A, Sergeant, J, Steinhausen, H-C, Taylor, E, Zuddas, A, Coghill, D (2009). The quality of life of children with attention deficit/hyperactivity disorder: a systematic review. European Child & Adolescent Psychiatry 19, 83105.Google Scholar
Doyle, AE (2015). Commentary: insights from across diagnostic boundaries: ADHD in the RDoC era – a commentary on Scerif and Baker (2015). Journal of Child Psychology and Psychiatry 56, 274277.Google Scholar
Foreman, DM (2010). The impact of governmental guidance on the time taken to receive medication for ADHD in England. Child and Adolescent Mental Health 15, 1217.Google Scholar
Foreman, DM, Dack, S, Ford, T (2008). Assessing the diagnostic accuracy of the identification of hyperkinetic disorders following the introduction of government guidelines in England. Child and Adolescent Psychiatry and Mental Health 2, 17. https://doi.org/10.1186/1753-2000-2-32 Google Scholar
Foreman, DM, Morton, S, Ford, T (2009). Exploring the clinical utility of the Development And Well-Being Assessment (DAWBA) in the detection of hyperkinetic disorders and associated diagnoses in clinical practice. Journal of Child Psychology and Psychiatry 50, 460470.Google Scholar
Frodl, T, Skokauskas, N (2012). Meta‐analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatrica Scandinavica 125, 114126.Google Scholar
Gambrill, E (2014). The Diagnostic and Statistical Manual of Mental Disorders as a major form of dehumanization in the modern world. Research on Social Work Practice 24, 1336.Google Scholar
Goodman, R, Ford, T, Richards, H, Gatward, R, Meltzer, H (2000). The Development and Well-Being Assessment: description and initial validation of an integrated assessment of child and adolescent psychopathology. Journal of Child Psychology & Psychiatry & Allied Disciplines 41, 645655.Google Scholar
Greenhalgh, J (2009). The applications of PROs in clinical practice: what are they, do they work, and why? Quality of Life Research 18, 115123.Google Scholar
Greven, CU, Merwood, A, Meer, JM, Haworth, C, Rommelse, N, Buitelaar, JK (2016). The opposite end of the attention deficit hyperactivity disorder continuum: genetic and environmental aetiologies of extremely low ADHD traits. Journal of Child Psychology and Psychiatry 57, 523531.Google Scholar
Groom, MJ, Young, Z, Hall, CL, Gillott, A, Hollis, C (2016). The incremental validity of a computerised assessment added to clinical rating scales to differentiate adult ADHD from autism spectrum disorder. Psychiatry Research 243, 168173.Google Scholar
Hall, CL, Valentine, AZ, Groom, MJ, Walker, GM, Sayal, K, Daley, D, Hollis, C (2015). The clinical utility of the continuous performance test and objective measures of activity for diagnosing and monitoring ADHD in children: a systematic review. European Child & Adolescent Psychiatry 25, 677699.Google Scholar
Hall, CL, Walker, GM, Valentine, AZ, Guo, B, Kaylor-Hughes, C, James, M, Daley, D, Sayal, K, Hollis, C (2014). Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD—‘Assessing QbTest Utility in ADHD’(AQUA): a randomised controlled trial. BMJ Open 4, e006838.Google Scholar
Hart, H, Radua, J, Nakao, T, Mataix-Cols, D, Rubia, K (2013). Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects. JAMA Psychiatry 70, 185198.Google Scholar
Hiscock, H, Sciberras, E, Mensah, F, Gerner, B, Efron, D, Khano, S, Oberklaid, F (2015). Impact of a behavioural sleep intervention on symptoms and sleep in children with attention deficit hyperactivity disorder, and parental mental health: randomised controlled trial. BMJ 350, h68.Google Scholar
Jensen, PS, Arnold, LE, Richters, JE, Severe, JB, Vereen, D, Schiller, E, Hinshaw, SP, Elliou, GR, Conners, CK, Wells, KC, Swanson, JM, Wigal, T, Cantwell, DP, Abikoff, HB, Hechtman, L, Newcorn, JH (1999). A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity ‘strong’ disorder. Archives of General Psychiatry 56, 10731086.Google Scholar
Kooij, SJJ, Bejerot, S, Blackwell, A, Caci, H, Casas-Brugué, M, Carpentier, PJ, Edvinsson, D, Fayyad, J, Foeken, K, Fitzgerald, M (2010). European consensus statement on diagnosis and treatment of adult ADHD: the European Network Adult ADHD. BMC Psychiatry 10, 67.Google Scholar
Kordon, A, Stollhoff, K, Niederkirchner, K, Mattejat, F, Rettig, K, Schäuble, B (2011). Exploring the impact of once-daily OROS® methylphenidate (MPH) on symptoms and quality of life in children and adolescents with ADHD transitioning from immediate-release MPH. Postgraduate Medicine 123, 2738.Google Scholar
Leo, J, Cohen, D (2009). A critical review of ADHD neuroimaging research. In Rethinking ADHD: From Brain to Culture (ed. S. Timimi and J. Leo), pp. 92129. Palgrave Macmillan: England.Google Scholar
Lindstrøm, JA (2012). Why attention-deficit/hyperactivity disorder is not a true medical syndrome. Ethical Human Psychology and Psychiatry 14, 6173.Google Scholar
Menon, V (2015). Salience network. In Brain Mapping: An Encyclopedic Reference, vol. 2 (ed. A. W. Toga), pp. 597–611. Academic Press: Elsevier.Google Scholar
Middeldorp, CM, Hammerschlag, AR, Ouwens, KG, Groen-Blokhuis, MM St., Pourcain, B, Greven, CU, Pappa, I, Tiesler, CMT, Ang, W, Nolte, IM, Vilor-Tejedor, N, Bacelis, J, Ebejer, JL, Zhao, H, Davies, GE, Ehli, EA, Evans, DM, Fedko, IO, Guxens, M, Hottenga, J-J, Hudziak, JJ, Jugessur, A, Kemp, JP, Krapohl, E, Martin, NG, Murcia, M, Myhre, R, Ormel, J, Ring, SM, Standl, M, Stergiakouli, E, Stoltenberg, C, Thiering, E, Timpson, NJ, Trzaskowski, M, van der Most, PJ, Wang, C, Nyholt, DR, Medland, SE, Neale, B, Jacobsson, B, Sunyer, J, Hartman, CA, Whitehouse, AJO, Pennell, CE, Heinrich, J, Plomin, R, Smith, GD, Tiemeier, H, Posthuma, D, Boomsma, DI (2016). A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based paediatric cohorts. Journal of the American Academy of Child & Adolescent Psychiatry 55, 896905.e6.Google Scholar
Moffitt, TE, Houts, R, Asherson, P, Belsky, DW, Corcoran, DL, Hammerle, M, Harrington, H, Hogan, S, Meier, MH, Polanczyk, GV, Poulton, R, Ramrakha, S, Sugden, K, Williams, B, Rohde, LA, Caspi, A (2015). Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort study. American Journal of Psychiatry 172, 967977.Google Scholar
Moncrieff, J, Timimi, S (2013). The social and cultural construction of psychiatric knowledge: an analysis of NICE guidelines on depression and ADHD. Anthropology & Medicine 20, 5971.Google Scholar
National Institutes for Health (2016). Human Connectome Project | Mapping the human brain connectivity (http://www.humanconnectomeproject.org/). Accessed 21 August 2016.Google Scholar
National Institute for Mental Health (2016). Research Domain Criteria (RDoC) (http://www.nimh.nih.gov/research-priorities/rdoc/index.shtml). Accessed 20 August 2016.Google Scholar
Phillips, CB (2006). Medicine goes to school: teachers as sickness brokers for ADHD. PLOS Medicine 3, e182.Google Scholar
Polanczyk, GV, Willcutt, EG, Salum, GA, Kieling, C, Rohde, LA (2014). ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis. International Journal of Epidemiology 43, 434442.Google Scholar
Quinn, M, Lynch, A (2016). Is ADHD a ‘real’ disorder? Support for Learning 31, 5970.Google Scholar
Rapport, MD, Orban, SA, Kofler, MJ, Friedman, LM (2013). Do programs designed to train working memory, other executive functions, and attention benefit children with ADHD? A meta-analytic review of cognitive, academic, and behavioral outcomes. Clinical Psychology Review 33, 12371252.Google Scholar
Rentz, AM, Matza, LS, Secnik, K, Swensen, A, Revicki, DA (2004). Psychometric validation of the child health questionnaire (CHQ) in a sample of children and adolescents with attention-deficit/hyperactivity disorder. Quality of Life Research 14, 719734.Google Scholar
Rosales, AG, Vitoratou, S, Banaschewski, T, Asherson, P, Buitelaar, J, Oades, RD, Rothenberger, A, Steinhausen, H-C, Faraone, SV, Chen, W (2015). Are all the 18 DSM-IV and DSM-5 criteria equally useful for diagnosing ADHD and predicting comorbid conduct problems? European Child & Adolescent Psychiatry 24, 13251337.Google Scholar
Rubio, B, Boes, AD, Laganiere, S, Rotenberg, A, Jeurissen, D, Pascual-Leone, A (2016). Noninvasive brain stimulation in pediatric attention-deficit hyperactivity disorder (ADHD): a review. Journal of Child Neurology 31, 784796.Google Scholar
Sacks, O (1992). Tourette’s syndrome and creativity. BMJ: British Medical Journal 305, 1515.Google Scholar
Sonuga-Barke, EJS, Brandeis, D, Cortese, S, Daley, D, Ferrin, M, Holtmann, M, Stevenson, J, Danckaerts, M, van der Oord, S, Döpfner, M, Dittmann, RW, Simonoff, E, Zuddas, A, Banaschewski, T, Buitelaar, J, Coghill, D, Hollis, C, Konofal, E, Lecendreux, M, Wong, ICK, Sergeant, J (2013). Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. American Journal of Psychiatry 170, 275289.Google Scholar
Storebø, OJ, Ramstad, E, Krogh, HB, Nilausen, TD, Skoog, M, Holmskov, M, Rosendal, S, Groth, C, Magnusson, FL, Moreira-Maia, CR, Gillies, D, Buch Rasmussen, K, Gauci, D, Zwi, M, Kirubakaran, R, Forsbøl, B, Simonsen, E, Gluud, C (2015). Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD). Cochrane Database of Systematic Reviews issue 11, CD009885.Google Scholar
Strakowski, SM, Frances, AJ (2012). What’s wrong with DSM-5?, Medscape (http://www.medscape.com/viewarticle/763886). Accessed 20 August 2016.Google Scholar
Taylor, D (1979). The components of sickness: diseases, illnesses, and predicaments. The Lancet 314, 10081010.Google Scholar
Thagaard, MS, Faraone, SV, Sonuga-Barke, EJ, Østergaard, SD (2016). Empirical tests of natural selection-based evolutionary accounts of ADHD: a systematic review. Acta Neuropsychiatrica 28, 249256.Google Scholar
Timimi, S, Leo, J (2008). Rethinking ADHD: From Brain to Culture. Palgrave Macmillan: Basingstoke.Google Scholar
Vogt, C, Shameli, A (2011). Assessments for attention-deficit hyperactivity disorder: use of objective measurements. The Psychiatrist Online 35, 380383.Google Scholar
Vysniauske, R, Verburgh, L, Oosterlaan, J, Molendijk, ML (2016). The effects of physical exercise on functional outcomes in the treatment of ADHD a meta-analysis. Journal of Attention Disorders, https://doi.org/10.1177/1087054715627489 Google Scholar
Williams, NM, Zaharieva, I, Martin, A, Langley, K, Mantripragada, K, Fossdal, R, Stefansson, H, Stefansson, K, Magnusson, P, Gudmundsson, OO, Gustafsson, O, Holmans, P, Owen, MJ, O’Donovan, M, Thapar, A (2010). Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376, 14011408.Google Scholar