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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL): a familial cause of depression and headache

Published online by Cambridge University Press:  13 June 2014

Killian O'Rourke ,
Niall Crumlish ,
Darra Murphy ,
John Stack  and
Brian Murray
Killian O'Rourke
Affiliation:
Mater Hospital, Dublin 7
Niall Crumlish
Affiliation:
St. James's Hospital, Dublin 8
Darra Murphy
Affiliation:
Mater Hospital, Dublin 7
John Stack
Affiliation:
Mater Hospital, Dublin 7
Brian Murray
Affiliation:
Mater Hospital, Dublin 7, Ireland
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Abstract

A 31 year-old man with a history of a depressive episode presented with acute severe ‘thunderclap’ headache. Magnetic resonance imaging (MRI) revealed abnormalities typical of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL), which was subsequently confirmed by genetic analysis. The psychiatric features of this genetic cause of depression and headache are discussed.

Keywords

CADASILDepressionHeadacheNotch 3 mutationChromosome 19
Type
Case reports
Information
Irish Journal of Psychological Medicine , Volume 27 , Issue 4 , December 2010 , pp. 215 - 216
Copyright
Copyright © Cambridge University Press 2010

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References

1.O'Sullivan, M, Jarosz, J, Martin, Ret at.MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology 2001; 13: 628–634.CrossRefGoogle Scholar
2.Monet, M, Domenga, V, Lemaire, Bet al.The archetypal R90C CADASIL-NOTCH 3 mutation retains NOTCH 3 function in vivo. Hum Mol Genet 2007; 16: 982–992.CrossRefGoogle Scholar
3.Razvi, S, Davidson, R, Bone, Iet al.The prevalence of CADASIL in the west of Scotland. J Neurol Neurosurg Psych 2005; 76: 739–741.CrossRefGoogle ScholarPubMed
4.Valenti, R, Poggesi, A, Pescini, Fet al.Psychiatric disturbances in CADASIL: a brief review. Acta Neurol Scand 2008; 118: 291–295.CrossRefGoogle ScholarPubMed
5.Desmond, D, Moroney, J, Lynch, Tet al.The natural history of CADASIL: a pooled analysis of previously published cases. Stroke 1999; 30: 1230–1233.CrossRefGoogle ScholarPubMed
6.Chabriat, H, Vahedi, K, Ibzizen, Met al.Clinical spectrum of CADASIL: a study of seven families. Lancet 1995; 346: 934–939.CrossRefGoogle Scholar
7.Kumar Mahr, G.CADASIL presenting as bipolar disorder. Psychosomatik 1997; 38: 397–398.CrossRefGoogle Scholar
8.Dupont, R, Jernigan, T, Heindel, Wet al.Magnetic resonance imaging and mood disorders. Localisation of white matter and other subcortical abnormalities. Arch Gen Psychiatry 1995; 52: 747–55.CrossRefGoogle ScholarPubMed
9.Ahearn, E, Speer, M, Chen, Yet al.Investigation of notch 3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. Am J Med Genet 2002; 114:652–658.CrossRefGoogle ScholarPubMed
10.Samaan, Z, Farmer, A, Craddock, Net al.Migraine in recurrent depression: case-control study. Br J Psychiatry 2009; 194: 350–354.CrossRefGoogle ScholarPubMed
11.Leyhe, T, Wiendl, H, Buchkremer, Get al.CADASIL: underdiagnosed in psychiatric patients? Acta Psychiatr Scand 2005; 111: 392–397.CrossRefGoogle ScholarPubMed
12.Ebke, M, Dichgans, M, Bergmann, Met al.CADASIL: skin biopsy allows diagnosis in early stages. Acta Neurol Scand 1997; 95: 351–357.CrossRefGoogle ScholarPubMed