Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-10T11:16:16.426Z Has data issue: false hasContentIssue false
  • English
  • Français

Clozapine induced encephalopathy

Published online by Cambridge University Press:  13 June 2014

Michael J Hennessy ,
Catrin N Pugh ,
Charles M Wiles  and
Sarah E Watkins
Charles M Wiles
Affiliation:
Department of Neurology, University Hospital of Wales, Cardiff, Wales.
Sarah E Watkins
Affiliation:
Department of Psychiatry, Whitchurch Hospital, Cardiff, Wales.
Get access Rights & Permissions [Opens in a new window]

Abstract

Clozapine has become a widely used drug in therapyresistant schizophrenia and, increasingly, in the levodopa-induced dyskinesias and the psychoses of chronic Parkinson's disease. We report the case of a 43 year old male patient who developed a reversible encephalopathy associated with clozapine therapy.

Keywords

ClozapineMyoclonusEncephalopathy.
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 15 , Issue 1 , March 1998 , pp. 29 - 30
Copyright
Copyright © Cambridge University Press 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Folstein, M, Folstein, S, McHugh, S. Mini-Mental State: a practical method for grading the cognitive status of patients for the clinician. J Psychiatric Res 1975; 12: 189–98.CrossRefGoogle Scholar
2.Thatcher, GW, Cates, M, Bair, B. Clozapine-induced toxic hepatitis (letter; comment). Am J Psychiatry 1995; 152(2): 296–7.Google Scholar
3.Marinkovic, D, Timotijevic, I, Babinsky, Tet al.The side effects of clozapine: a four year follow-up study. Prog Neuropsychopharmacol Biol Psychiatry. 1994 18(3): 537–44.CrossRefGoogle ScholarPubMed
4.Klawans, HL, Carvey, PM, Tanner, CM, et, al. Drug induced myoclonus. In: Fahn, S, Marsden, CD, VanWoert, M eds. Myoclonus: advances in neurology. Vol 43. New York, NY: Raven Press, 1986: 251–264.Google Scholar
5.Bak, TH, Bauer, M, Schaub, RT, Hellweg, R, Reischies, FM. Myoclonus in patients treated with clozapine-a case series. J Clin Psychiatry 1995: 56(9): 418–22.Google Scholar
6.Pacia, SV, Devinsky, O. Clozapine-related seizures: experience with 5,629 patients. Neurology 1994; 44, 2247–9.CrossRefGoogle Scholar
7.Welch, J, Manschreck, T, Redmond, D. Clozapine-induced seizures and EEG changes. J Neuropsychiatry Clin Neurosci 1994; 6(3): 250–6.Google ScholarPubMed
8.Gouloulis, E, Ozdaglar, A, Kasper, J. Myoclonic seizures followed by grand mal seizures during clozapine treatment, (letter). Am J Psychiatry 1993; 150: 1, 28.Google Scholar
9.Berman, J, Zalma, A, Du Rand, CJet al.Clozapine-induced myoclonic jerks and drop attacks (letter). J Clin Psychiatry 1992; 53: 329–330.Google Scholar
10.Risby, ED, Epstein, CM, Jewart, RDet al.Clozapine-induced EEG abnormalities and clinical response to clozapine. J Neuropsychiatry Clin Neurosci 1995; 466–70.Google ScholarPubMed
11.Denney, D, Stevens, JR. Clozapine and seizures. Biol Psychiatry 1995; 37(7): 427–33.CrossRefGoogle ScholarPubMed
12.Baldessarini, RJ, Huston-Lyons, D, Campbell, Aet al.Do central anti-adrenergic actions contribute to the atypical properties of clozapine? Br J Psychiatry 1992; (suppl): 12–16.CrossRefGoogle Scholar
13.Bharucha, KJ, Zamrini, E, Evans, Det al.Clozapine-induced asterixis (abstract). Neurology 1996; 46 (2)(suppl): A 262.Google Scholar