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Diabetes and brain health: implications for practice

Published online by Cambridge University Press:  10 November 2015

C. Dolan ,
J. McHugh Open the ORCID record for J. McHugh [Opens in a new window]  and
B. Lawlor
C. Dolan*
Affiliation:
Department of Psychiatry, Jonathan Swift Clinic, St. James’s Hospital, Dublin, Ireland
J. McHugh
Affiliation:
Department of Psychiatry, Jonathan Swift Clinic, St. James’s Hospital, Dublin, Ireland
B. Lawlor
Affiliation:
Department of Psychiatry, Jonathan Swift Clinic, St. James’s Hospital, Dublin, Ireland
*
*Address for correspondence: Dr C. Dolan, Psychiatry Department, Jonathan Swift Clinic, St. James’s Hospital, Dublin 8, Ireland. (Email: cadolan@stjames.ie)
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Abstract

Background

It is widely accepted that people with mental illness have increased risk of cardiometabolic complications such as obesity and type 2 diabetes mellitus. What is less well known is that individuals with diabetes have an increased risk of brain health complications including depression, cognitive impairment and dementia. These conditions can adversely influence disease self-management and further increase risk of other diabetes complications.

Aim

The aim of this paper is to highlight the increased risk of brain health complications in populations with diabetes in order to promote awareness of such complications among healthcare professionals and encourage timely intervention.

Methods

An overview of the prevalence and potential mechanisms linking depression and cognitive impairment with diabetes as well as implications for detection, management and brain health protection, based on a narrative review of the literature.

Conclusions

Early detection and effective management of depression and cognitive impairment among individuals with diabetes has the potential to minimise adverse health outcomes. In order to promote screening healthcare professionals caring for individuals with diabetes in all settings must be aware of the increased risk of brain health complications in this vulnerable population.

Keywords

Dementiadepressionmental disordersmild cognitive impairmenttype 2 diabetes mellitus
Type
Review Article
Information
Irish Journal of Psychological Medicine , Volume 33 , Issue 3 , September 2016 , pp. 179 - 191
Copyright
© College of Psychiatrists of Ireland 2015 

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References

Abitbol, R, Rej, S, Segal, M, Looper, KJ (2015). Diabetes mellitus onset in geriatric patients: does long-term atypical antipsychotic exposure increase risk? Psychogeriatrics 15, 43–50.Google Scholar
Aikens, JE, Perkins, DW, Lipton, B, Piette, JD (2009). Longitudinal analysis of depressive symptoms and glycemic control in type 2 diabetes. Diabetes Care 32, 1177–1181.Google Scholar
Albert, MS, DeKosky, ST, Dickson, D, Dubois, B, Feldman, HH, Fox, NC, Gamst, A, Holtzman, DM, Jagust, WJ, Petersen, RC, Snyder, PJ, Carrillo, MC, Thies, B, Phelps, CH (2011). The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7, 270–279.Google Scholar
Ali, S, Stone, MA, Peters, JL, Davies, MJ, Khunti, K (2006). The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis. Diabetic Medicine 23, 1165–1173.CrossRefGoogle ScholarPubMed
American Diabetes Association (2015). Older adults. Sec. 10. In Standards of Medical Care in Diabetes—2015. Diabetes Care 38 (Suppl. 1), S67–S69.Google Scholar
Anderson, RJ, Freedland, KE, Clouse, RE, Lustman, PJ (2001). The prevalence of comorbid depression in adults with diabetes a meta-analysis. Diabetes Care 24, 1069–1078.Google Scholar
Arvanitakis, Z, Wilson, RS, Bienias, JL, Evans, DA, Bennett, DA (2004). Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Archives of Neurology 61, 661–666.Google Scholar
Atlantis, E, Fahey, P, Foster, J (2014). Collaborative care for comorbid depression and diabetes: a systematic review and meta-analysis. BMJ Open 4, 1–10.Google Scholar
Azevedo Da Silva, M, Dugravot, A, Balkau, B, Roussel, R, Fumeron, F, Elbaz, A, Canonico, M, Singh-Manoux, A, Nabi, H, D.E.S.I.R. Study Group (2015). Antidepressant medication use and trajectories of fasting plasma glucose, glycated haemoglobin, β-cell function and insulin sensitivity: a 9-year longitudinal study of the D.E.S.I.R. cohort. International Journal of Epidemiology. doi:10.1093/ije/dyv153.Google Scholar
Banerjee, C, Moon, YP, Paik, MC, Rundek, T, Mora-McLaughlin, C, Vieira, JR, Sacco, RL, Elkind, MS (2012). Duration of diabetes and risk of ischemic stroke: the Northern Manhattan study. Stroke 43, 1212–1217.Google Scholar
Beck, AT, Ward, CH, Mendelson, M, Mock, J, Erbaugh, J (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–571.Google Scholar
Biessels, GJ, Deary, IJ, Ryan, CM (2008). Cognition and diabetes: a lifespan perspective. The Lancet Neurology 7, 184–190.Google Scholar
Biessels, GJ, Reijmer, YD (2014). Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes 63, 2244–2252.Google Scholar
Bonnet, F, Irving, K, Terra, J-L, Nony, P, Berthezène, F, Moulin, P (2005). Anxiety and depression are associated with unhealthy lifestyle in patients at risk of cardiovascular disease. Atherosclerosis 178, 339–344.Google Scholar
Borson, S, Scanlan, J, Brush, M, Vitaliano, P, Dokmak, A (2000). The mini-cog: a cognitive ‘vital signs’ measure for dementia screening in multi-lingual elderly. International Journal of Geriatric Psychiatry 15, 1021–1027.Google Scholar
Brands, AMA, Biessels, GJ, Haan, EHF, de Kappelle, LJ, Kessels, RPC (2005). The effects of type 1 diabetes on cognitive performance a meta-analysis. Diabetes Care 28, 726–735.Google Scholar
Brown, ES, Varghese, FP, McEwen, BS (2004). Association of depression with medical illness: does cortisol play a role? Biological Psychiatry 55, 1–9.Google Scholar
Bruce, DG (2015). Type 2 diabetes and cognitive function: many questions, few answers. The Lancet Neurology 14, 241–242.Google Scholar
Bruce, DG, Davis, WA, Casey, GP, Starkstein, SE, Clarnette, RM, Almeida, OP, Davis, TME (2008). Predictors of cognitive decline in older individuals with diabetes. Diabetes Care 31, 2103–2107.Google Scholar
Bruce, DG, Davis, WA, Starkstein, SE, Davis, TM (2014). Mid-life predictors of cognitive impairment and dementia in type 2 diabetes mellitus: the Fremantle Diabetes Study. Journal of Alzheimer’s Disease 42 (Suppl 3): S63–S70.Google Scholar
Buydens-Branchey, L, Branchey, M, Hudson, J, Fergeson, P (2000). Low HDL cholesterol, aggression and altered central serotonergic activity. Psychiatry Research 93, 93–102.Google Scholar
Central Statistics Office (2013). Population and Labour Force Projections, 2016-2046. Central Statistics Office: Ireland.Google Scholar
Champaneri, S, Wand, GS, Malhotra, SS, Casagrande, SS, Golden, SH (2010). Biological basis of depression in adults with diabetes. Current Diabetes Report 10, 396–405.Google Scholar
Chan, O, Chan, S, Inouye, K, Vranic, M, Matthews, SG (2001). Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment. Endocrinology 142, 4872–4879.Google Scholar
Chen, C, Wang, Y, Zhang, J, Ma, L, Gu, J, Ho, G (2014). Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice. Disease Models & Mechanisms 7, 723–730.Google Scholar
Cheng, G, Huang, C, Deng, H, Wang, H (2012). Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies: diabetes and cognitive function. Internal Medicine Journal 42, 484–491.Google Scholar
Chiu, S-L, Chen, C-M, Cline, HT (2008). Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 58, 708–719.Google Scholar
Christman, AL, Vannorsdall, TD, Pearlson, GD, Hill-Briggs, F, Schretlen, DJ (2010). Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample. Archives of Clinical Neuropsychology 25, 49–59.CrossRefGoogle Scholar
Cooper, C, Sommerlad, A, Lyketsos, CG, Livingston, G (2015). Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. The American Journal of Psychiatry 172, 323–334.Google Scholar
Cosway, R, Strachan, MWJ, Dougall, A, Frier, BM, Deary, IJ (2001). Cognitive function and information processing in type 2 diabetes. Diabetic Medicine 18, 803–810.Google Scholar
Coventry, P, Lovell, K, Dickens, C, Bower, P, Chew-Graham, C, McElvenny, D, Hann, M, Cherrington, A, Garrett, C, Gibbons, CJ, Baguley, C, Roughley, K, Adeyemi, I, Reeves, D, Waheed, W, Gask, L (2015). Integrated primary care for patients with mental and physical multimorbidity: cluster randomised controlled trial of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease. BMJ 350, h638.Google Scholar
Cukierman-Yaffe, T, Gerstein, HC, Anderson, C, Zhao, F, Sleight, P, Hilbrich, L, Jackson, SHD, Yusuf, S, Teo, K, ONTARGET/TRANSCEND Investigators (2009). Glucose intolerance and diabetes as risk factors for cognitive impairment in people at high cardiovascular risk: results from the ONTARGET/TRANSCEND research programme. Diabetes Research and Clinical Practice 83, 387–393.Google Scholar
Dantzer, R, O’Connor, JC, Freund, GG, Johnson, RW, Kelley, KW (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews. Neuroscience 9, 46–56.Google Scholar
Das-Munshi, J, Stewart, R, Ismail, K, Bebbington, PE, Jenkins, R, Prince, MJ (2007). Diabetes, common mental disorders, and disability: findings from the UK National Psychiatric Morbidity Survey. Psychosomatic Medicine 69, 543–550.Google Scholar
De Groot, M, Anderson, R, Freedland, KE, Clouse, RE, Lustman, PJ (2001). Association of depression and diabetes complications: a meta-analysis. Psychosomatic Medicine 63, 619–630.Google Scholar
De Groot, M, Doyle, T, Kushnick, M, Shubrook, J, Merrill, J, Rabideau, E, Schwartz, F (2012). Can lifestyle interventions do more than reduce diabetes risk? Treating depression in adults with type 2 diabetes with exercise and cognitive behavioral therapy. Current Diabetes Reports 12, 157–166.Google Scholar
De Jonge, P, Alonso, J, Stein, DJ, Kiejna, A, Aguilar-Gaxiola, S, Viana, MC, Liu, Z, O’Neill, S, Bruffaerts, R, Caldas-de-Almeida, JM, Lepine, J-P, Matschinger, H, Levinson, D, de Girolamo, G, Fukao, A, Bunting, B, Haro, JM, Posada-Villa, JA, Al-Hamzawi, AO, Medina-Mora, ME, Piazza, M, Hu, C, Sasu, C, Lim, CCW, Kessler, RC, Scott, KM (2014). Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression. Diabetologia 57, 699–709.CrossRefGoogle ScholarPubMed
De Vet, E, de Ridder, DTD, de Wit, JBF (2011). Environmental correlates of physical activity and dietary behaviours among young people: a systematic review of reviews. Obesity Reviews 12, e130–e142.Google Scholar
DiMatteo, MR, Lepper, HS, Croghan, TW (2000). Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Archives of Internal Medicine 160, 2101–2107.Google Scholar
Egede, LE, Ellis, C (2010). Diabetes and depression: global perspectives. Diabetes Research and Clinical Practice 87, 302–312.Google Scholar
Egede, LE, Nietert, PJ, Zheng, D (2005). Depression and all-cause and coronary heart disease mortality among adults with and without diabetes. Diabetes Care 28, 1339–1345.Google Scholar
Elcombe, EL, Lagopoulos, J, Duffy, SL, Lewis, SJG, Norrie, L, Hickie, IB, Naismith, SL (2015). Hippocampal volume in older adults at risk of cognitive decline: the role of sleep, vascular risk, and depression. Journal of Alzheimer’s Disease 44, 1279–1290.Google Scholar
Espeland, MA, Miller, ME, Goveas, JS, Hogan, PE, Coker, LH, Williamson, J, Naughton, M, Resnick, SM (2011). Cognitive function and fine motor speed in older women with diabetes mellitus: results from the women’s health initiative study of cognitive aging. Journal of Women’s Health 20, 1435–1443.Google Scholar
Exalto, LG, Biessels, GJ, Karter, AJ, Huang, ES, Katon, WJ, Minkoff, JR, Whitmer, RA (2013). Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: a cohort study. The Lancet Diabetes & Endocrinology 1, 183–190.Google Scholar
Feil, DG, Zhu, CW, Sultzer, DL (2012). The relationship between cognitive impairment and diabetes self-management in a population-based community sample of older adults with type 2 diabetes. Journal of Behavioral Medicine 35, 190–199.Google Scholar
Gallacher, JEJ, Pickering, J, Elwood, PC, Bayer, AJ, Yarnell, JW, Ben-Shlomo, Y (2005). Glucoregulation has greater impact on cognitive performance than macro-vascular disease in men with type 2 diabetes: data from the Caerphilly study. European Journal of Epidemiology 20, 761–768.Google Scholar
Gonzalez, JS, Peyrot, M, McCarl, LA, Collins, EM, Serpa, L, Mimiaga, MJ, Safren, SA (2008). Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care 31, 2398–2403.Google Scholar
Gorska-Ciebiada, M, Saryusz-Wolska, M, Borkowska, A, Ciebiada, M, Loba, J (2015). Serum levels of inflammatory markers in depressed elderly patients with diabetes and mild cognitive impairment. PLoS One 10, 1–17.Google Scholar
Harten, B, van Leeuw, F-E, de Weinstein, HC, Scheltens, P, Biessels, GJ (2006). Brain imaging in patients with diabetes a systematic review. Diabetes Care 29, 2539–2548.Google Scholar
Hermanns, N, Kulzer, B, Krichbaum, M, Kubiak, T, Haak, T (2005). Affective and anxiety disorders in a German sample of diabetic patients: prevalence, comorbidity and risk factors. Diabetic Medicine 22, 293–300.CrossRefGoogle Scholar
Holt, P (2014). Blood glucose monitoring in diabetes. Nursing Standard 28, 52–58.Google Scholar
Holt, RIG, de Groot, M, Golden, SH (2014). Diabetes and depression. Current Diabetes Reports 14, 491.Google Scholar
Howren, MB, Lamkin, DM, Suls, J (2009). Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic Medicine 71, 171–186.Google Scholar
Huang, Y, Wei, X, Wu, T, Chen, R, Guo, A (2013). Collaborative care for patients with depression and diabetes mellitus: a systematic review and meta-analysis. BMC Psychiatry 13, 260.Google Scholar
Hutter, N, Schnurr, A, Baumeister, H (2010). Healthcare costs in patients with diabetes mellitus and comorbid mental disorders—a systematic review. Diabetologia 53, 2470–2479.Google Scholar
International Diabetes Federation (2013). Managing Older People with Type 2 Diabetes. International Diabetes Federation: Brussels, Belgium. www.idf.org.Google Scholar
International Diabetes Federation (2014). IDF Diabetes Atlas Update Poster, 6th edn. International Diabetes Federation: Brussels, Belgium. http://www.idf.org/diabetesatlas.Google Scholar
Ismail, K, Maissi, E, Thomas, S, Chalder, T, Schmidt, U, Bartlett, J, Patel, A, Dickens, C, Creed, F, Treasure, J (2010). A randomised controlled trial of cognitive behaviour therapy and motivational interviewing for people with type 1 diabetes mellitus with persistent sub-optimal glycaemic control: a Diabetes and Psychological Therapies (ADaPT) study. Health Technology Assessment 14, 1–101, iii–iv.Google Scholar
Kan, C, Silva, N, Golden, SH, Rajala, U, Timonen, M, Stahl, D, Ismail, K (2013). A systematic review and meta-analysis of the association between depression and insulin resistance. Diabetes Care 36, 480–489.Google Scholar
Katon, W, Pedersen, H, Ribe, AR, Fenger-Grøn, M, Davydow, D, Waldorff, FB, Vestergaard, M (2015). Effect of depression and diabetes mellitus on the risk for dementia: a national population-based cohort study. JAMA Psychiatry 72, 612–619.Google Scholar
Katon, WJ, Lin, EHB, Williams, LH, Ciechanowski, P, Heckbert, SR, Ludman, E, Rutter, C, Crane, PK, Oliver, M, Von Korff, M (2010). Comorbid depression is associated with an increased risk of dementia diagnosis in patients with diabetes: a prospective cohort study. Journal of General Internal Medicine 25, 423–429.Google Scholar
Katon, WJ, Rutter, C, Simon, G, Lin, EHB, Ludman, E, Ciechanowski, P, Kinder, L, Young, B, Von Korff, M (2005). The association of comorbid depression with mortality in patients with type 2 diabetes. Diabetes Care 28, 2668–2672.Google Scholar
Knol, MJ, Twisk, JWR, Beekman, ATF, Heine, RJ, Snoek, FJ, Pouwer, F (2006). Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia 49, 837–845.Google Scholar
Kooistra, M, Geerlings, MI, Mali, WPTM, Vincken, KL, van der Graaf, Y, Biessels, GJ (2013). Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. The SMART-MR study. Journal of the Neurological Sciences 332, 69–74.Google Scholar
Kothari, V, Stevens, RJ, Adler, AI, Stratton, IM, Manley, SE, Neil, HA, Holman, RR (2002). UKPDS 60: risk of stroke in type 2 diabetes estimated by the UK prospective diabetes study risk engine. Stroke 33, 1776–1781.Google Scholar
Kumar, A, Gupta, R, Thomas, A, Ajilore, O, Hellemann, G (2009). Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression. Archives of General Psychiatry 66, 324–330.Google Scholar
Kumar, A, Yang, S, Ajilore, O, Wu, M, Cohen, J, Lamar, M, Bhaumik, D (2015). Biophysical changes in subcortical nuclei: the impact of diabetes and major depression. Molecular Psychiatry, doi:10.1038/mp.2015.89.Google Scholar
Launer, LJ, Miller, ME, Williamson, JD, Lazar, RM, Gerstein, HC, Murray, AM, Sullivan, M, Horowitz, KR, Ding, J, Marcovina, S, Lovato, LC, Lovato, J, Margolis, KL, O’Connor, P, Lipkin, EW, Hirsch, J, Coker, L, Maldjian, J, Sunshine, JL, Truwit, C, Davatzikos, C, Bryan, RN, ACCORD MIND investigators (2011). Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurology 10, 969–977.Google Scholar
Li, C, Ford, ES, Strine, TW, Mokdad, AH (2008). Prevalence of depression among U.S. adults with diabetes: findings from the 2006 behavioral risk factor surveillance system. Diabetes Care 31, 105–107.Google Scholar
Li, C, Ford, ES, Zhao, G, Balluz, LS, Berry, JT, Mokdad, AH (2010). Undertreatment of mental health problems in adults with diagnosed diabetes and serious psychological distress. Diabetes Care 33, 1061–1064.Google Scholar
Luchsinger, JA (2012). Type 2 diabetes and cognitive impairment: linking mechanisms. Journal of Alzheimer’s Disease 30, S185–S198.Google Scholar
Luppino, FS, de Wit, LM, Bouvy, PF, Stijnen, T, Cuijpers, P, Penninx, BWJH, Zitman, FG (2010). Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Archives of General Psychiatry 67, 220–229.Google Scholar
Lustman, PJ, Clouse, RE (2005). Depression in diabetic patients: the relationship between mood and glycemic control. Journal of Diabetes and its Complications 19, 113–122.Google Scholar
Lustman, PJ, Griffith, LS, Clouse, RE (1988). Depression in adults with diabetes: results of 5-yr follow-up study. Diabetes Care 11, 605–612.Google Scholar
McCrimmon, RJ, Ryan, CM, Frier, BM (2012). Diabetes and cognitive dysfunction. The Lancet 379, 2291–2299.Google Scholar
McFall, GP, Geall, BP, Fischer, AL, Dolcos, S, Dixon, RA (2010). Testing covariates of type 2 diabetes-cognition associations in older adults: moderating or mediating effects? Neuropsychology 24, 547–562.Google Scholar
Mehrabian, S, Raycheva, M, Gateva, A, Todorova, G, Angelova, P, Traykova, M, Stankova, T, Kamenov, Z, Traykov, L (2012). Cognitive dysfunction profile and arterial stiffness in type 2 diabetes. Journal of the Neurological Sciences 322, 152–156.Google Scholar
Mezuk, B, Eaton, WW, Albrecht, S, Golden, SH (2008). Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 31, 2383–2390.Google Scholar
Mitchell, AJ (2012). Psychiatric aspects of chronic physical disease. Medicine 40, 662–665.Google Scholar
Monette, MCE, Baird, A, Jackson, DL (2014). A meta-analysis of cognitive functioning in nondemented adults with type 2 diabetes mellitus. Canadian Journal of Diabetes 38, 401–408.Google Scholar
Moran, C, Phan, TG, Chen, J, Blizzard, L, Beare, R, Venn, A, Münch, G, Wood, AG, Forbes, J, Greenaway, TM, Pearson, S, Srikanth, V (2013). Brain atrophy in type 2 diabetes regional distribution and influence on cognition. Diabetes Care 36, 4036–4042.Google Scholar
Munshi, M, Capelson, R, Grande, L, Lin, S, Hayes, M, Milberg, W, Ayres, D, Weinger, K, Suhl, E (2006). Cognitive dysfunction is associated with poor diabetes control in older adults. Diabetes Care 29, 1794–1799.Google Scholar
Musselman, DL, Betan, E, Larsen, H, Phillips, LS (2003). Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biological Psychiatry 54, 317–329.Google Scholar
Nandipati, S, Luo, X, Schimming, C, Grossman, HT, Sano, M (2012). Cognition in non-demented diabetic older adults. Current Aging Science 5, 131–135.Google Scholar
Nasreddine, ZS, Phillips, NA, Bédirian, V, Charbonneau, S, Whitehead, V, Collin, I, Cummings, JL, Chertkow, H (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society 53, 695–699.Google Scholar
Norton, S, Matthews, FE, Barnes, DE, Yaffe, K, Brayne, C (2014). Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. The Lancet Neurology 13, 788–794.CrossRefGoogle ScholarPubMed
Nouwen, A, Nefs, G, Caramlau, I, Connock, M, Winkley, K, Lloyd, CE, Peyrot, M, Pouwer, F (2011). Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium. Diabetes Care 34, 752–762.Google Scholar
Nouwen, A, Winkley, K, Twisk, J, Lloyd, CE, Peyrot, M, Ismail, K, Pouwer, F (2010). Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia 53, 2480–2486.Google Scholar
Novak, V, Zhao, P, Manor, B, Sejdić, E, Alsop, D, Abduljalil, A, Roberson, PK, Munshi, M, Novak, P (2011). Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care 34, 2438–2441.Google Scholar
Okura, T, Heisler, M, Langa, KM (2009). The association of cognitive function and social support with glycemic control in adults with diabetes. Journal of American Geriatrics Society 57, 1816–1824.Google Scholar
Park, M, Katon, WJ, Wolf, FM (2013). Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review. General Hospital Psychiatry 35, 217–225.Google Scholar
Petrak, F, Baumeister, H, Skinner, TC, Brown, A, Holt, RIG (2015). Depression and diabetes: treatment and health-care delivery. Lancet Diabetes Endocrinol 3, 472–485.Google Scholar
Peyrot, M, Rubin, RR (1999). Persistence of depressive symptoms in diabetic adults. Diabetes Care 22, 448–452.Google Scholar
Peyrot, M, Rubin, RR, Lauritzen, T, Snoek, FJ, Matthews, DR, Skovlund, SE (2005). Psychosocial problems and barriers to improved diabetes management: results of the Cross-National Diabetes Attitudes, Wishes and Needs (DAWN) Study. Diabetic Medicine 22, 1379–1385.Google Scholar
Peyrot, M, Burns, KK, Davies, M, Forbes, A, Hermanns, N, Holt, R, Kalra, S, Nicolucci, A, Pouwer, F, Wens, J, Willaing, I, Skovlund, SE (2013). Diabetes Attitudes Wishes and Needs 2 (DAWN2): a multinational, multi-stakeholder study of psychosocial issues in diabetes and person-centered diabetes care. Diabetes Research and Clinical Practice 99, 174–184.Google Scholar
Punthakee, Z, Miller, ME, Launer, LJ, Williamson, JD, Lazar, RM, Cukierman-Yaffee, T, Seaquist, ER, Ismail-Beigi, F, Sullivan, MD, Lovato, LC, Bergenstal, RM, Gerstein, HC, ACCORD Group of Investigators, ACCORD-MIND Investigators (2012). Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial. Diabetes Care 35, 787–793.Google Scholar
Radloff, LS (1977). The CES-D Scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1, 385–401.Google Scholar
Raevuori, A, Suokas, J, Haukka, J, Gissler, M, Linna, M, Grainger, M, Suvisaari, J (2015). Highly increased risk of type 2 diabetes in patients with binge eating disorder and bulimia nervosa. The International Journal of Eating Disorders 48, 555–562.Google Scholar
Reijmer, YD, Leemans, A, Brundel, M, Kappelle, LJ, Biessels, GJ, on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group (2013). Disruption of the cerebral white matter network is related to slowing of information processing speed in patients with type 2 diabetes. Diabetes 62, 2112–2115.Google Scholar
Reijmer, YD, van den Berg, E, Ruis, C, Kappelle, LJ, Biessels, GJ (2010). Cognitive dysfunction in patients with type 2 diabetes. Diabetes/Metabolism Research and Reviews 26, 507–519.Google Scholar
Rotella, F, Mannucci, E (2013 a). Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies. Diabetes Research and Clinical Practice 99, 98–104.Google Scholar
Rotella, F, Mannucci, E (2013 b). Depression as a risk factor for diabetes: a meta-analysis of longitudinal studies. Journal of Clinical Psychiatry 74, 31–37.Google Scholar
Samaras, K, Sachdev, PS (2012). Diabetes and the elderly brain: sweet memories? Therapeutic Advances in Endocrinology and Metabolism 3, 189–196.Google Scholar
Sartorius, N, Holt, RIG, Maj, M (2014). Comorbidity of Mental and Physical Disorders. Karger Medical and Scientific Publishers: Basal, Switzerland.Google Scholar
Shoelson, SE, Lee, J, Goldfine, AB (2006). Inflammation and insulin resistance. The Journal of Clinical Investigation 116, 1793–1801.Google Scholar
Smith, MA, Else, JE, Paul, L, Foster, JK, Walker, M, Wesnes, KA, Riby, LM (2014). Functional living in older adults with type 2 diabetes: executive functioning, dual task performance, and the impact on postural stability and motor control. Journal of Aging and Health 26, 841–859.Google Scholar
Spitzer, RL, Kroenke, K, Williams, JB (1999). Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 282, 1737–1744.Google Scholar
Subramaniam, M, Chong, S-A, Pek, E (2003). Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia. Canadian Journal of Psychiatry 48, 345–347.Google Scholar
Talbot, K, Wang, H-Y, Kazi, H, Han, L-Y, Bakshi, KP, Stucky, A, Fuino, RL, Kawaguchi, KR, Samoyedny, AJ, Wilson, RS (2012). Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. The Journal of Clinical Investigation 122, 1316–1338.Google Scholar
Taylor, D, Young, C, Mohamed, R, Paton, C, Walwyn, R (2005). Undiagnosed impaired fasting glucose and diabetes mellitus amongst inpatients receiving antipsychotic drugs. Journal of Psychopharmacology 19, 182–186.Google Scholar
Thambisetty, M, Metter, EJ, Yang, A, Dolan, H, Marano, C, Zonderman, AB, Troncoso, JC, Zhou, Y, Wong, DF, Ferrucci, L, Egan, J, Resnick, SM, O’Brien, RJ (2013). Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore longitudinal study of aging. JAMA Neurology 70, 1167–1172.Google Scholar
Toro, P, Schönknecht, P, Schröder, J (2009). Type II diabetes in mild cognitive impairment and Alzheimer’s disease: results from a prospective population-based study in Germany. Journal of Alzheimer’s Disease 16, 687–691.Google Scholar
United Nations, Department of Economic and Social Affairs, Population Division (2015). World population prospects: the 2015 revision, key findings and advance tables. Working Paper No. ESA/P/WP.241, United Nations, Department of Economic and Social Affairs, Population Division, New York, USA.Google Scholar
Van den Berg, E, Kloppenborg, RP, Kessels, RPC, Kappelle, LJ, Biessels, GJ (2009). Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: a systematic comparison of their impact on cognition. Biochimica et Biophysica Acta 1792, 470–481.Google Scholar
Van den Berg, E, Reijmer, YD, de Bresser, J, Kessels, RPC, Kappelle, LJ, Biessels, GJ (2010). A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetologia 53, 58–65.Google Scholar
Van Dooren, FEP, Nefs, G, Schram, MT, Verhey, FRJ, Denollet, J, Pouwer, F (2013). Depression and risk of mortality in people with diabetes mellitus: a systematic review and meta-analysis. PLoS One 8, 1–11.Google Scholar
Van Elderen, SGC, de Roos, A, de Craen, AJM, Westendorp, RGJ, Blauw, GJ, Jukema, JW, Bollen, ELEM, Middelkoop, HAM, van Buchem, MA, van der Grond, J (2010). Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up. Neurology 75, 997–1002.Google Scholar
Van Steenbergen-Weijenburg, KM, van Puffelen, AL, Horn, EK, Nuyen, J, van Dam, PS, van Benthem, TB, Beekman, ATF, Rutten, FFH, Hakkaart-van Roijen, L, van der Feltz-Cornelis, CM (2011). More co-morbid depression in patients with type 2 diabetes with multiple complications. An observational study at a specialized outpatient clinic. Diabetic Medicine 28, 86–89.Google Scholar
Velayudhan, L, Poppe, M, Archer, N, Proitsi, P, Brown, RG, Lovestone, S (2010). Risk of developing dementia in people with diabetes and mild cognitive impairment. The British Journal of Psychiatry 196, 36–40.Google Scholar
Verdile, G, Fuller, SJ, Martins, RN (2015). The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, doi:10.1016/j.nbd.2015.04.008.Google Scholar
Verdelho, A, Madureira, S, Moleiro, C, Ferro, JM, Santos, CO, Erkinjuntti, T, Pantoni, L, Fazekas, F, Visser, M, Waldemar, G, Wallin, A, Hennerici, M, Inzitari, D, LADIS Study (2010). White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study. Neurology 75, 160–167.Google Scholar
Voruganti, LP, Punthakee, Z, Van Lieshout, RJ, MacCrimmon, D, Parker, G, Awad, AG, Gerstein, HC (2007). Dysglycemia in a community sample of people treated for schizophrenia: the Diabetes in Schizophrenia in Central-South Ontario (DiSCO) study. Schizophrenia Research 96, 215–222.Google Scholar
Walker, RJ, Smalls, BL, Hernandez-Tejada, MA, Campbell, JA, Davis, KS, Egede, LE (2012). Effect of diabetes fatalism on medication adherence and self-care behaviors in adults with diabetes. General Hospital Psychiatry 34, 598–603.Google Scholar
Welch, G, Weinger, K, Anderson, B, Polonsky, WH (2003). Responsiveness of the problem areas in diabetes (PAID) questionnaire. Diabetic Medicine 20, 69–72.Google Scholar
Welch, GW, Jacobson, AM, Polonsky, WH (1997). The problem areas in diabetes scale: an evaluation of its clinical utility. Diabetes Care 20, 760–766.Google Scholar
Yaffe, K, Falvey, C, Hamilton, N, Schwartz, AV, Simonsick, EM, Satterfield, S, Cauley, JA, Rosano, C, Launer, LJ, Strotmeyer, ES, Harris, TB (2012). Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. Archives of Neurology 69, 1–12.Google Scholar
Yu, M, Zhang, X, Lu, F, Fang, L (2015). Depression and risk for diabetes: a meta-analysis. Canadian Journal of Diabetes 39, 266–272.Google Scholar
Zhao, W-Q, Townsend, M (2009). Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer’s disease. Biochimica et Biophysica Acta 1792, 482–496.Google Scholar
Zigmond, AS, Snaith, RP (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 67, 361–370.Google Scholar