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Kleine-Levin Syndrome: a female case report and review

Published online by Cambridge University Press:  13 June 2014

John A. Cooney*
Affiliation:
Department of Psychiatry, Cork Regional Hospital
*
Box 1000, Ponoka, Alberta, Canada, TOC 2HO (Currently: Chief, Substance Abuse Service, Alberta Hospital Ponoka, Canada.)

Abstract

The Kleine-Levin Syndrome (KLS) a rare disorder comprising of periodic bouts of hypersomnia and megaphagia is reviewed. The syndrome chiefly affects males. The four accepted female cases in the literature are reviewed and a new female case described. This patient had an IQ in the normal range, unlike the other three female cases where the IQ was measured. She showed an abnormal Cortisol rhythm during both a well and an unwell phase replicating the findings of other workers in some KLS patients. This patient showed normal dexamethasone suppression, a test not previously reported on in KLS. The patient also smoked excessively during the bouts, an occurrence not previously remarked on in this disorder.

Type
Clinical and Brief Reports
Copyright
Copyright © Cambridge University Press 1989

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References

1.Critchley, M, Hoffman, H L. The syndrome of periodic hyper-somnolence and morbid hunger (Kleine-Levin Syndrome). Br Med J 1942; 1: 137139.CrossRefGoogle Scholar
2.Antimoff, J A quoted by Kaplinsky, M S, Schulman, E D. Uber Die Periodische Schlafucht. Acta Med Scand 1935; 85: 107128.Google Scholar
3.Kleine, W. Periodische Schlafsucht. Monatsschrift für Psychiatric und Neurol 1925; 57: 285320.CrossRefGoogle Scholar
4.Levin, M. Periodic somnolence and morbid hunger: a new syndrome. Brain 1936; 59: 494504.CrossRefGoogle Scholar
5.Critchley, M. Periodic hypersomnia and megaphagia in adolescent males. Brain 1962; 85: 627656.CrossRefGoogle ScholarPubMed
6.Orlosky, M J. The Kleine-Levin Syndrome: a review. Psychosomatics 1982; 23: 609621.CrossRefGoogle ScholarPubMed
7.Parkes, J D. The sleepy patient. Lancet 1977; i: 990993.Google Scholar
8.Sours, J A. Narcolepsy and other disturbances in the sleep-waking rhythm: A study of 115 cases with a review of the literature. J Nerv Ment Dis 1963; 137: 525542.CrossRefGoogle ScholarPubMed
9.Sachs, C, Persson, H E, Hagenfeld, K. Menstruation-related hypersomnia: a case study with successful treatment. Neurology 1982; 32: 13761379.CrossRefGoogle ScholarPubMed
10.Ferguson, B G. Kleine-Levin Syndrome: A case report. J Child Psychol Psychiatry 1986; 27: 275278.Google ScholarPubMed
11.Gallinek, A. Syndrome of episodes of hypersomnia, bulimia and abnormal mental states. JAMA 1954; 154: 10811083.CrossRefGoogle ScholarPubMed
12.George, H R. A case of Kleine-Levin Syndrome of long duration. Br J Psychiatry 1970; 117: 521523.CrossRefGoogle ScholarPubMed
13.Oswald, I. Sleep and its disorders. In: Vinken, PJ, Bruyn, GW, eds. Handbook of clinical neurology. Amsterdam: North Holland Publishing, 1969; 3: 80111.Google Scholar
14.Williams, R L, Karacan, I. Sleep disorders and disorderd sleep. In: Arieti, S, Reiser, M, eds. American Handbook of Psychiatry. New York: Basic Books 1975; 4: 854904.Google Scholar
15.Garland, H, Summer, D, Fourman, P. The Kleine-Levin Syndrome: some further observations. Neurology 1965; 15: 11611168.CrossRefGoogle ScholarPubMed
16.Thompson, C, Obrecht, R, Franey, Cet al.Neuroendocrine rhythms in a patient with the Kleine-Levine Syndrome. Br J Psychiatry 1985; 147: 440443.CrossRefGoogle Scholar
17.Livrea, P, Puca, F M, Barnaba, A. Abnormal central monamine metabolism in humans with ‘true hypersomnia’ and ‘sub-wakefullness’. Eur Neurol 1977; 15: 7176.CrossRefGoogle Scholar
18.Snead, O C. Minireview: Gamma hydroxybutyrate. Life Sci 1977; 20: 19351944.CrossRefGoogle Scholar
19.Earle, B V. Periodic hypersomnia and megaphagia (the Kleine-Levin Syndrome). Psychiatr Q 1965; 39: 7983.CrossRefGoogle ScholarPubMed
20.Tyrer, P. Toward rational therapy with Monoamine Oxidase Inhibitors. Br J Psychiatry 1976; 128: 354360.CrossRefGoogle Scholar
21.Gilbert, G J. Periodic hypersomnia and bulimia - The Kleine-Levin Syndrome. Neurology 1964; 14: 844850.CrossRefGoogle ScholarPubMed
22.Duffy, J P, Davison, K. A female case of Kleine-Levin Syndrome. Br J Psychiatry 1968; 114: 7784.CrossRefGoogle ScholarPubMed
23.Gilligan, B S. Periodic megaphagia and hypersomnia - an example of the Kleine-Levin Syndrome in an adolescent girl. Proc Aust Assoc Neurol 1973; 9: 6772.Google Scholar