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Lithium toxicity, hypomania and leucocytosis with fluoxetine

Published online by Cambridge University Press:  13 June 2014

Padraig Wright
Affiliation:
Bethlem Royal and Maudsley Hospitals, Denmark Hill, London SE5
Ram Seth
Affiliation:
Bethlem Royal and Maudsley Hospitals, Denmark Hill, London SE5

Abstract

The first case in which lithium toxicity and leucocytosis with hypomania appear to have been induced by the selective serotonin reuptake blocking antidepressant, fluoxetine, is described. The possible pathophysiology of this interaction is discussed.

Type
Clinical & Brief Reports
Copyright
Copyright © Cambridge University Press 1992

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References

1.Settle, EC, Settle, GP. A case of mania associated with fluoxetine. Am J Psychiatry 1984; 141: 280281.Google ScholarPubMed
2.Turner, SM, Jacob, RG, Beidel, DC, Griffin, S. A second case of mania associated with fluoxetine. Am J Psychiatry 1985; 142: 274275.Google ScholarPubMed
3.Chouinard, G, Steiner, W. A case of mania induced by high-dose fluoxetine treatment. Am J Psychiatry 1986; 143: 686.CrossRefGoogle ScholarPubMed
4.Salama, AA, Shafey, M. A case of severe lithium toxicity induced by combined fluoxetine and lithium carbonate. Am J Psychiatry 1989; 146: 278.Google ScholarPubMed
5.Pope, HG, McElroy, SL, Nixon, RA. Possible synergism between fluoxetine and lithium in refractory depression. Am J Psychiatry 1988; 145: 12921294.Google ScholarPubMed
6.Hadley, A, Cason, MP. Mania resulting from lithium fluoxetine combination. Am J Psychiatry 1989; 146: 16371638.Google ScholarPubMed
7.Noveske, FG, Hahn, KR, Flynn, RJ. Possible toxicity of combined fluoxetine and lithium. Am J Psychiatry 1989; 146: 1515.Google ScholarPubMed
8.Mayfield, D, Brown, RG. The clinical, laboratory and electroencephalographical effects of lithium. J Psychiatr Res 1966; 4: 207212.CrossRefGoogle ScholarPubMed
9.Bunney, WE, Goodwin, FK, Murphy, DL, House, KM, Gordon, EK. The switch process in manic-depressive illness, II: relationship to catecholamines, REM sleep and drugs. Arch Gen Psychiatry 1972; 27: 304309.CrossRefGoogle ScholarPubMed
10.Tisman, G, Herbert, V, Rosenbatt, S. Evidence that lithium induces human granulocyte proliferation: elevated serum vitamin B12 binding capacity in vivo and granulocyte colony proliferation in vitro. Br J Haematol 1973; 24: 767771.CrossRefGoogle ScholarPubMed