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Platelet serotonin aggregation in depression

Published online by Cambridge University Press:  13 June 2014

Helen Keely ,
Mary Ring ,
Anne MM Dunne ,
Michael J Kelleher  and
Finbarr Corkery
Helen Keely
Affiliation:
Suicide Research Foundation, 1 Perrott Avenue, College Road, Cork, Ireland
Mary Ring
Affiliation:
Haematology Dept
Anne MM Dunne
Affiliation:
Professorial Unit, Cork University Hospital, Cork, Ireland
Michael J Kelleher
Affiliation:
Suicide Research Foundation, Perrott Ave, College Rd, Cork, Ireland
Finbarr Corkery
Affiliation:
Medi-Group, Cathedral Rd, Cork, Ireland
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Abstract

Serotonin aggregation is a measure of function of platelet 5-HT2 receptors. The test has been proposed as a valid peripheral model of central 5-HT2 receptor function. Receptors of this subtype are implicated in theories of the aetiology of depressive states.

This pilot study proposes a normal range for the test for both males and females. Untreated depressed subjects had results which grouped at the lower end of the range. The test proved reproducible with a correlation coefficient of r = 0.939 with an interval of at least six weeks between sampling. A small number of successfully treated patients were retested with no empirical difference in their results, which are included in the reproducibility studies.

Our provisional results indicate the reliability of serotonin aggregation scores for an individual. The difference in scores noted in depressed subjects is more likely to be a trait rather than a state marker.

Type
Orginal Papers
Information
Irish Journal of Psychological Medicine , Volume 13 , Issue 3 , September 1996 , pp. 97 - 99
Copyright
Copyright © Cambridge University Press 1996

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References

1Leonard, B. Blood cells as models of neurones studies in the affective disorder. J Ir College of Physicians and Surgeons 1991; 2(4): 284–92.Google Scholar
2.Rang, HP, Dale, M. Pharmacology. 2nd ed. 1991: 200–1.Google Scholar
3.Cook, EH Jr, Fletcher, KE, Wainwright, M, et at.Primary structure of the human platelet serotonin 5-HTM2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. J Neurochem 1994; 63(2): 465–9.CrossRefGoogle ScholarPubMed
4.Brusov, OS, et at.Does platelet serotonin receptor super sensitivity accompany endogenous depression?Biol Psychiatry 1989; 375–81.Google Scholar
5.Coppen, AJ, Doogan, PD. Serotonin and its place in the pathogenesis of depression. J Clin Psychiatry 1989; 49(8, suppl).Google Scholar
6.Stanley, Mann JJ. Increased serotonin two binding sites in frontal cortex of suicide victims. Lancet 1983; 1: 214–16.CrossRefGoogle Scholar
7.Golden, RN, Gilmore, JH, Corrigan, MHN. Serotonin suicide and aggression technical studies. J Clin Psychiatry 1991; 52(12): 61–9.Google Scholar
8.Traskman, L, Asberg, M, Bertilsson, L, Sjostrand, L. Monamine metabolites in CSFand suicidal behaviour. Arch Gen Psychiatry 1987; 38: 631–6.CrossRefGoogle Scholar
9.Roy, A, DeJong, J, Linnoila, M. Cerebrospinal fluid monoamine metabolites and suicidal Behaviour in depressed patients. Arch Gen Psychiatry 1989; 46: 609–12.CrossRefGoogle ScholarPubMed
10.Coccaro, E., Siever, IJ, Klar, HM. Serotinergic studies in patients with affective and personality disorders. Arch Gen Psychiatry 1989; 46: 587–99.CrossRefGoogle Scholar
11.Lucey, JV, O'Keane, V, Butcher, G, Clare, AW, Dinan, TG. Cortisol and Prolactin. Responses to D-Fenfluramine in non-depressed patients with obsessive compulsive disorder. A comparison with depressed and healthy controls. Br J Psych 1992; 161: 517–21.CrossRefGoogle ScholarPubMed
12.Geracioti, TD Jr, et at.Serial cerebrospinal fluid corticotrophin - releasing hormone concentration in healthy and depressed humans. J Clin Endrocrinol Metab 1992; 74(6)1325–30.Google ScholarPubMed
13.Healy, D, Egan, EL. Scan J Haematology 1984; 32: 452–6.CrossRefGoogle Scholar
14.Nugent, DF, Dinan, TG, Leonard, BE. Alteration by a plasma factor(s) of platelet aggregation in unmedicated unipolar depressed patients. J Affect Disord 1994; 31.Google Scholar
15.Schick, BP, Schick, PK. Megakaryocyte biochemistry. Semin haematol 1986; 23: 84.Google ScholarPubMed
16.ECA Study quoted in Companion to Psychiatric Studies. Kendall and Healy 4th ed. Livingston: Churchill, 1988.Google Scholar