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Treatment considerations in clozapine induced enuresis or incontinence

Published online by Cambridge University Press:  13 June 2014

Tunde D. Apantaku-Olajide
Tunde D. Apantaku-Olajide*
Affiliation:
Dublin University Psychiatry Rotational Training Programme, Dublin, Ireland
*
*Correspondence Email: tunyapans@yahoo.com
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Abstract

Antipsychotic related urinary symptoms are recognised and they remain a potential treatment-limiting sideeffect of clozapine. This article reports the incidence and management of two cases of clozapine-associated incontinence in psychiatrically stable patients. Both cases occurred during treatment and appear to have a similar pathophysiology, which may be related to the atypical nature of clozapine therapy. We searched the PubMed and MEDLINE databases for articles published from 1980 to 2008 that contain the keywords 'clozapine and enuresis, ‘clozapine and incontinence,’ ‘clozapine and seizures’. We also manually searched the bibliographies of these articles for related sources, and explored the reported treatment options to this side-effect of clozapine therapy. Both patients gave an informed consent.

Keywords

ClozapineEnuresisIncontinenceSeizureSodium valproate
Type
Case Report
Information
Irish Journal of Psychological Medicine , Volume 27 , Issue 2 , June 2010 , pp. 99 - 100
Copyright
Copyright © Cambridge University Press 2010

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