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A glutathione deficiency in the red cells of certain Merino sheep

Published online by Cambridge University Press:  27 March 2009

Elizabeth M. Tucker  and
L. Kilgour
Elizabeth M. Tucker
Affiliation:
A.R.C. Institute of Animal Physiology, Babraham, Cambridge
L. Kilgour
Affiliation:
A.R.C. Institute of Animal Physiology, Babraham, Cambridge
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Summary

Red cell GSH concentrations were measured in 83 pure-bred and 65 cross-bred Tasmanian Merino sheep. A bimodal distribution was found; 40% of sheep had mean GSH values of 27·3 ± 1·2 mg and 60% had 92·2 ± 1·5 mg/100 ml red cells. Family data are limited, but they suggest that this difference is under genetic control, the gene for low GSH levels being dominant to that for high. Unlike GSH-low type Finnish Landrace sheep, GSH-low type Merino sheep do not have lower than normal red cell sodium and potassium concentrations.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 79 , Issue 3 , December 1972 , pp. 515 - 516
Copyright
Copyright © Cambridge University Press 1972

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References

REFERENCES

Beutler, E., Duron, O. & Kelly, B. M. (1963). Improved method for the determination of blood glutathione. J. Lab. clin. Med. 61, 882–8.Google ScholarPubMed
Tucker, E. M. & Kilgour, L. (1970). An inherited glutathione deficiency and a concomitant reduction in potassium concentration in sheep red cells. Experientia 26, 203–4.CrossRefGoogle Scholar
Tucker, E. M. & Ellory, J. C. (1971). The cation composition of the red cells of sheep with an inherited deficiency of reduced glutathione. Res. vet. Sci. 12, 600–2.CrossRefGoogle ScholarPubMed