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Potential of immunization for increasing animal production

Published online by Cambridge University Press:  27 March 2009

A. T. Holder ,
R. Aston  and
D. J. Flint
A. T. Holder
Affiliation:
AFRC Institute for Grassland and Animal Production, Hurley, Berks SL6 SLR, UK
R. Aston
Affiliation:
Peptide Technology Ltd, PO Box 444, Dee Why, NSW2099, Australia
D. J. Flint
Affiliation:
Hannah Research Institute, Ayr, Scotland KA6 5HL, UK
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Extract

The use of exogenous hormone treatment as a means of increasing the efficiency of animal production has, in general, been rather poorly received by both the public and government agencies. This antipathy towards hormone treatment has tended to direct research effort into finding less contentious ‘hormonefree’ methods of improving animal production. Over the last 10 years, immunological manipulation of the endocrine system has emerged as an attractive possibility in this search. In this review we briefly outline three approaches under current consideration, whereby growth hormone (GH) concentrations or activity are modified. These methods involve immunological manipulation of GH release, use of antibodies as GH mimics and antibody-mediated enhancement of GH action.

Information

Type
Review
Information
The Journal of Agricultural Science , Volume 116 , Issue 2 , April 1991 , pp. 175 - 181
Copyright
Copyright © Cambridge University Press 1991

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References

REFERENCES

Abdel-Meguid, S. S., Shieh, H. S., Smith, W. W., Dayringer, H. E., Violand, B. N. & Bentle, L. A. (1987). Three-dimensional structure of a genetically engineered variant of porcine growth hormone. Proceedings of the National Academy of Sciences, United States of America 84, 6434–6437.CrossRefGoogle ScholarPubMed
Arimura, A., Smith, W. D. & Schally, A. V. (1976). Blockade of the stress-induced decrease in blood growth hormone by antisomatostatin serum in rats. Endocrinology 98, 540–543.CrossRefGoogle ScholarPubMed
Aston, R., Holder, A. T., Ivanyi, J. & Bomford, P. (1987). Enhancement of bovine growth hormone activity in vivo by monoclonal antibodies. Molecular Immunology 24, 143–150.CrossRefGoogle ScholarPubMed
Aston, R., Holder, A. T., Preece, M. A. & Ivanyi, J. (1986). Potentiation of the somatogenic and lactogenic activity of human growth hormone with monoclonal antibodies. Journal of Endocrinology 110, 381–388.CrossRefGoogle ScholarPubMed
Aston, R. & Ivanyi, J. (1985). Monoclonal antibodies to growth hormone and prolactin. Pharmacology and Therapeutics 27, 403–424.CrossRefGoogle Scholar
Barnard, R., Bundesen, P. G., Rylatt, D. B. & Waters, M. J. (1985). Evidence from the use of monoclonal antibody probes for structural heterogeneity of the growth hormone receptor. Biochemical Journal 231, 459–468.CrossRefGoogle ScholarPubMed
Bass, J. J., Gluckman, P. D., Fairclough, R. J., Peterson, A. J., Davis, S. R. & Carter, W. D. (1987). Effect of nutrition and immunization against somatostatin on growth and insulin-like growth factors in sheep. Journal of Endocrinology 112, 27–31.CrossRefGoogle ScholarPubMed
Deligeorgis, S. G., Rogdakis, E., Mantzios, A., Nikolau, E., Evangelatos, G. & Sotiriadis-Vlahos, C. (1988). A note on the effect of active immunization against somatostatin on milk production and growth in sheep. Animal Production 46, 304–308.Google Scholar
Dubreuil, P., Pelletier, G., Petitclerc, D., Lapierre, H., Gaudrea, P. & Brazeau, P. (1989). Effects of active immunization against somatostatin on serum growth hormone concentration in growing pigs: influence of fasting and repetitive somatocrinin injections. Endocrinology 125, 1378–1384.CrossRefGoogle ScholarPubMed
Fadlalla, A. M., Spencer, G. S. G. & Lister, D. (1985). Passive immunization against somatostatin and marker retention time in lambs. Journal of Animal Science 61, 234–239.CrossRefGoogle ScholarPubMed
Farid, N. R., Pepper, B., Urbina-Briones, R. & Islam, N. R. (1982). Biological activity of anti-thyrotropin and anti-idiotypic antibody. Journal of Cellular Biochemistry 19, 305–313.CrossRefGoogle ScholarPubMed
Gardner, M. J., Morrison, C. A., Stevenson, L. Q. & Flint, D. J. (1990). Production of anti-idiotypic antisera to rat GH antibodies capable of binding to GH receptors and increasing body weight gain in hypophysectomized rats. Journal of Endocrinology 125, 53–59.CrossRefGoogle ScholarPubMed
Garssen, G. J., Welling, A. M. A. W. & Spencer, G. S. G. (1987). Active immunization against somatostatin increases milk yield in goats. Netherlands Journal of Agricultural Science 35, 84–86.CrossRefGoogle Scholar
Holder, A. T. & Aston, R. (1988). Antibody enhancement of GH action in vivo. In Current Medical Literature: Growth and Growth Factors, 3 (Eds Buchanan, C., Hindmarsh, P. & Ross, R.), pp. 133–139. London: The Royal Society of Medicine.Google Scholar
Holder, A. T., Aston, R., Preece, M. A. & Ivanyi, J. (1985). Monoclonal antibody mediated enhancement of growth hormone activity in vivo. Journal of Endocrinology 107, R9–R12.CrossRefGoogle ScholarPubMed
Holder, A. T., Aston, R., Rest, J. R., Hill, D. J., Patel, N. & Ivanyi, J. (1987). Monoclonal antibodies can enhance the biological activity of thyrotrophin. Endocrinology 120, 567–573.CrossRefGoogle Scholar
Holder, A. T., Blows, J., Aston, R. & Bates, P. C. (1988). Monoclonal antibody enhancement of the effects of human growth hormone on growth and body composition in mice. Journal of Endocrinology 117, 85–90.CrossRefGoogle ScholarPubMed
Holder, A. T., Wallis, M., Biggs, P. & Preece, M. A. (1980). Effects of growth hormone, prolactin and thyroxine on body weight, somatomedin-like activity and in vivosulphation of cartilage in hypopituitary dwarf mice. Journal of Endocrinology 85, 35–47.CrossRefGoogle ScholarPubMed
Jerne, N. K. (1974). Towards a network theory of the immune system. Annales dlmmunologie, Paris 125C, 373–389.Google ScholarPubMed
Kahn, C. R., Baird, K., Flier, J. S. & Jarett, D. B. (1977). Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and action. Journal of Clinical Investigation 60, 1094–1106.CrossRefGoogle Scholar
Pell, J. M., Johnsson, I. D., Pullar, R. A., Morrell, D.J., Hart, I. C., Holder, A. T. & Aston, R. (1989). Potentiation of growth hormone activity in sheep using monoclonal antibodies. Journal of Endocrinology 120, R15–R18.CrossRefGoogle ScholarPubMed
Petitclerc, G., Pelletier, G., Dubreuil, P., Lapierre, H., Farmer, C. & Brazeau, P. (1988). Effects of active immunization against somatostatin and growth hormone releasing factor infusion on growth hormone secretion in dairy heifers. Journal of Animal Science 66 (Suppl. 1), 389.Google Scholar
Reichlin, S. (1983). Somatostatin. New England Journal of Medicine 309, 1495–1501.CrossRefGoogle ScholarPubMed
Spencer, G. S. G. (1987). Biotechnology in the potential practical application of somatotrophic hormones for improving animal performance. Reproduction, Nutrition and Development 27 (2B9), 581–589.CrossRefGoogle ScholarPubMed
Spencer, G. S. G., Garssen, G. J. & Hart, I. C. (1983). A novel approach to growth promotion using auto-immunization against somatostatin. I. Effect on growth and hormone levels in lambs. Livestock Production Science 10, 25–37.CrossRefGoogle Scholar
Tannenbaum, G. S., Epelbaum, J., Colle, E., Brazeau, P. & Martin, J. B. (1978). Antiserum to somatostatin reverses starvation-induced inhibition of growth hormone but not insulin secretion. Endocrinology 102, 1909–1914.CrossRefGoogle Scholar
Terry, L. C. & Martin, J. B. (1981). The effects of lateral hypothalamic medial forebrain stimulation and somatostatin antiserum on pulsatile growth hormone secretion in freely behaving rats: evidence for a dual regulatory mechanism. Endocrinology 109, 622–627.CrossRefGoogle ScholarPubMed
Thomas, H., Green, I. C., Wallis, M. & Aston, R. (1987). Heterogeneity of growth hormone receptors detected with monoclonal antibodies to human growth hormone. Biochemical Journal 243, 365–372.CrossRefGoogle ScholarPubMed
Wallis, M., Daniels, M., Ray, K. P., Cottingham, J. D. & Aston, R. (1987). Monoclonal antibodies to bovine growth hormone potentiate effects of the hormone on somatomedin-C levels and growth of hypophysectomised rats. Biochemical and Biophysical Research Communications 149, 187–193.CrossRefGoogle Scholar