Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-28T14:28:01.628Z Has data issue: false hasContentIssue false
  • English
  • Français

Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)

Published online by Cambridge University Press:  06 February 2001

G. J. P. L. KOPS  and
B. M. T. BURGERING
G. J. P. L. KOPS
Affiliation:
Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
B. M. T. BURGERING
Affiliation:
Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
Get access

Abstract

Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3′-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.

Keywords

Protein kinase Bc-akt
Type
Minireview
Information
The Journal of Anatomy , Volume 197 , Issue 4 , November 2000 , pp. 571 - 574
Copyright
© Anatomical Society of Great Britain and Ireland 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)