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Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)

Published online by Cambridge University Press:  06 February 2001

G. J. P. L. KOPS  and
B. M. T. BURGERING
G. J. P. L. KOPS
Affiliation:
Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
B. M. T. BURGERING
Affiliation:
Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
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Abstract

Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3′-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.

Keywords

Protein kinase Bc-akt
Type
Minireview
Information
The Journal of Anatomy , Volume 197 , Issue 4 , November 2000 , pp. 571 - 574
Copyright
© Anatomical Society of Great Britain and Ireland 2000

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