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GENETIC AND ENVIRONMENTAL INFLUENCES ON BLOOD PRESSURE IN AN URBAN INDIAN POPULATION

Published online by Cambridge University Press:  15 August 2012

SHILPI GUPTA  and
SATWANTI KAPOOR
SHILPI GUPTA
Affiliation:
Obesity Research Unit, Physiological Anthropological Laboratory, Department of Anthropology, University of Delhi, India
SATWANTI KAPOOR
Affiliation:
Obesity Research Unit, Physiological Anthropological Laboratory, Department of Anthropology, University of Delhi, India
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Summary

Aggarwal Baniyas were found to have a high prevalence of high blood pressure. Genetic and environmental influences may be implicated for this risk factor of cardiovascular disease. The aim of this study was to investigate the potential for common genetic and environmental influences on blood pressure measures (systolic and diastolic blood pressure (SBP, DBP)). The population-based sample was comprised of 309 Aggarwal Baniya families, including 1214 individuals (271 fathers, 307 mothers, 311 sons and 325 daughters) from New Delhi, India. The prevalence of obesity in this community was found to be high (BMI: fathers, 26.1 kg/m2; mothers, 29.4 kg/m2; sons, 16.9–22.4 kg/m2; and daughters, 16.3–22.7 kg/m2). Correlation and heritability were estimated. Most sibling–sibling correlations were larger than the parent–offspring correlations, and all parent–offspring and sibling–sibling correlations were larger than the corresponding spouse correlation (SBP=0.026; DBP=0.029). The maximum heritability was estimated as 44.6% for SBP and 62.8% for DBP. The lack of a significant spouse correlation is consistent with little or no influence of the common familial environment. However, the high heritability estimate for both SBP and DBPs reinforces the importance of the non-shared environmental effect.

Type
Research Article
Information
Journal of Biosocial Science , Volume 45 , Issue 1 , January 2013 , pp. 1 - 11
Copyright
Copyright © Cambridge University Press 2012

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References

Annest, J. L., Sing, C. F., Biron, P. & Mongeau, J. (1979) Familial aggregation of blood pressure and weight in adoptive families. II. Estimation of the relative contributions of genetic and common environmental factors to blood pressure correlations between family member. Epidemiology 110, 492–503.Google Scholar
Austin, M. A., King, M. C., Bawol, R. D., Hulley, S. B. & Friedman, G. D. (1987) Risk factors for coronary heart disease in adult female twins. Genetic heritability and shared environmental influences. American Journal of Epidemiology 125, 308–318.CrossRefGoogle ScholarPubMed
Barker, D. J. P., Gluckman, P. D., Godfrey, K. M., Harding, J. E., Owens, J. A. & Robinson, J. S. (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341, 938–941.CrossRefGoogle ScholarPubMed
Barker, D. J. P., Osmond, C., Golding, J., Kuh, D. & Wadsworth, M. E. J. (1989) Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. British Medical Journal 298, 564–567.CrossRefGoogle ScholarPubMed
Chiu, Y. H., Lin, W. Y., Wang, P. E., Chen, Y. D., Wang, T. T., Warwick, J. & Chen, T. H. H. (2007) Population-based family case–control proband study on familial aggregation of metabolic syndrome: finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS No. 5). Diabetes Research and Clinical Practice 75, 348–356.CrossRefGoogle Scholar
Cooper, R. & Rotimi, C. (1994) Hypertension in populations of West African origin: is there a genetic predisposition? Journal of Hypertension 12, 215–227.Google ScholarPubMed
Cooper, R., Rotimi, C., Ataman, S., McGee, D., Osotimehin, B., Kadiri, S., Muna, W. et al. (1997) The prevalence of hypertension in seven populations of West African origin. American Journal of Public Health 87, 160–168.CrossRefGoogle ScholarPubMed
Cusi, D., Barlassina, C., Azzani, T., Casari, G., Citterio, L., Devoto, M. et al. (1997) Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 349, 1353–1357.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1981) Introduction to Quantitative Genetics, 2nd edition. Longman, London and New York.Google Scholar
Falconer, D. S. (1989) Introduction to Quantitative Genetics, 3rd edition. Longman Scientific and Technical, Esgender, UK.Google Scholar
Flodmark, C. E., Ohlsson, T., Ryden, O. & Sveger, T. (1993) Prevention of progression to severe obesity in a group of obese schoolchildren treated with family therapy. Pediatrics 91, 880–884.CrossRefGoogle Scholar
Gupta, S. & Kapoor, S. (2010) Sex differences in blood pressure levels and its association with obesity indices: who is at greater risk? Ethnicity and Disease 20, 370–375.Google ScholarPubMed
Harrap, S. B. (1994) Hypertension: genes versus environment. Lancet 344, 169–171.CrossRefGoogle ScholarPubMed
Hata, A., Namikawa, C., Sasaki, M., Sato, K., Nalamura, T., Tamura, K. & Lalouel, J. M. (1994) Angiotensinogen as a risk factor for essential hypertension in Japan. Journal of Clinical Investigation 93, 1285–1287.CrossRefGoogle ScholarPubMed
Havlik, R. J., Garrison, R. J., Feinleib, M., Kannel, W. B., Castelli, W. P. & McNamara, P. M. (1979) Blood pressure aggregation in families. American Journal of Epidemiology 110, 304–312.CrossRefGoogle ScholarPubMed
Jeunemaitre, X., Soubrier, F., Kotelevtsev, Y. V., Lifton, R. P., Williams, C. S., Charru, A. et al. (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71, 169–180.CrossRefGoogle ScholarPubMed
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K. & He, J. (2005) Global burden of hypertension: analysis of worldwide data. Lancet 365, 217–223.CrossRefGoogle ScholarPubMed
Knuiman, M. W., Divitini, M. L., Welborn, T. A. & Bartholomew, H. C. (1996) Familial correlations, cohabitation effects, and heritability for cardiovascular risk factors. Annal of Epidemiology 6, 188–194.CrossRefGoogle ScholarPubMed
Lawes, C. M., Vander Hoorn, S., Law, M. R., Elliott, P., MacMahon, S. & Rodgers, A. (2006) Blood pressure and the global burden of disease 2000. Part II: estimates of attributable burden. Journal of Hypertension 24, 423–443.CrossRefGoogle ScholarPubMed
Lifton, R. P. (1996) Molecular genetics of human blood pressure variation. Science 272, 676–680.CrossRefGoogle ScholarPubMed
Lin, H. F., Boden-Albala, B., Juo, S. H., Park, N., Rundek, T. & Sacco, R. L. (2005) Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study. Diabetologia 48(10), 2006–2012.CrossRefGoogle ScholarPubMed
Longini, I. M., Higgins, H. W., Hinton, P. C., Moll, P. P. & Keller, J. B. (1984) Environmental and genetic sources of familial aggregation of blood pressure in Tecumseh, Michigan. American Journal of Epidemiology 120, 131–144.CrossRefGoogle ScholarPubMed
Mackenzie, H. S. & Brenner, B. M. (1995) Fewer nephrons at birth: a missing link in the etiology of essential hypertension? American Journal of Kidney Diseases 26, 91–98.CrossRefGoogle ScholarPubMed
Mackenzie, H. S., Lawler, E. V. & Brenner, B. M. (1996) Congenital oligonephropathy: the fetal flaw in essential hypertension? Kidney International 49 (Supplement 55), S30–34.Google Scholar
Marmot, M. G. (1979) Early life and adult disorder: research themes. British Medical Bulletin 53, 3–9.CrossRefGoogle Scholar
Martyn, C. N., Barker, D. J. P., Jespersen, S., Greenwald, S., Osmond, C. & Berry, C. (1995) Growth in utero, adult blood pressure, and arterial compliance. British Heart Journal 73, 116–121.CrossRefGoogle ScholarPubMed
Mayer, E. J., Newman, B. & Austin, M. A. (1996) Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins. American Journal of Epidemiology 143, 323–332.CrossRefGoogle ScholarPubMed
Mitchell, B. D., Kammerer, C. M. & Blangero, J. (1996) Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans: the San Antonio Family Heart Study. Circulation 94, 2159–2170.CrossRefGoogle ScholarPubMed
Morton, N. E., Guldbrandsen, C. L., Rao, D.C., Rhoads, G. G. & Kagan, A. (1980) Determinants of blood pressure in Japanese–American families. Human Genetic 53, 261–266.CrossRefGoogle ScholarPubMed
Ounsted, M. K., Cockburn, J. M., Moar, V. A. & Redman, C. W. G. (1985) Factors associated with the blood pressures of children born to women who were hypertensive during pregnancy. Archives of Disease in Childhood 60, 631–635.CrossRefGoogle ScholarPubMed
Ozanne, S. E. & Hales, C. N. (2002) Early programming of glucose–insulin metabolism. Trends in Endocrinology and Metabolism 13, 368–373.CrossRefGoogle ScholarPubMed
Park, H. S., Park, J. Y. & Cho, S. I. (2006) Familial aggregation of the metabolic syndrome in Korean families with adolescents. Atherosclerosis 186, 215–221.CrossRefGoogle ScholarPubMed
Poulsen, P., Vaag, A., Kyvik, K. & Beck-Nielsen, H. (2001) Genetic versus environmental aetiology of the metabolic syndrome among male and female twins. Diabetologia 44, 537–543.CrossRefGoogle ScholarPubMed
Stamler, J., Berkson, D. M., Dyer, A., Lepper, M. H., Lindberg, H. A., Oglesby, P. et al. (1975) Relationship of multiple variables to blood pressure: findings from four Chicago epidemiologic studies. In Paul, O. (ed.) Epidemiology and Control of Hypertension. Symposia Specialists, Miami, FL, pp. 307–358.Google Scholar
Susanne, C. (1975) Genetic and environmental influences on morphological characteristics. Annals of Human Biology 2, 279–287.CrossRefGoogle ScholarPubMed
Tambs, K., Mourn, T. & Eaves, L. (1991) Genetic and environmental contributions to the variance of the body mass index in a Norwegian sample of first- and second-degree relatives. American Journal of Human Biology 3, 257–267.CrossRefGoogle Scholar
Tambs, K., Mourn, T. & Holmen, J. (1992) Genetic and environmental effects on blood pressure in a Norwegian sample. Genetic Epidemiology 9, 11–26.CrossRefGoogle Scholar
Wadden, T. A., Stunkard, A. J. & Rich, L. (1990) Obesity in black adolescent girls: a controlled clinical trial of treatment by diet, behaviour modification, and parental support. Pediatrics 85, 345–352.CrossRefGoogle ScholarPubMed
Ward, R. H., Chin, P. G. & Prior, I. A. M. (1979) Genetic epidemiology of blood pressure in migrating isolate: prospectus. In Sing, C. F. & Skolnick, M. (eds) Genetic Analysis of Common Diseases: Application to Predictive Factors in Coronary Disease. Alan R. Liss, New York, NY, pp. 675–709.Google Scholar
Williams, R. R., Hunt, S. C., Hasstedt, S. J., Hopkins, P. N., Wu, L. L., Berry, T. D. et al. (1991) Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure? Hypertension 18 (Supplement I), I29–37.CrossRefGoogle ScholarPubMed