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Normative study of age variation in salivary progesterone profiles

Published online by Cambridge University Press:  31 July 2008

S. F. Lipson
Affiliation:
Department of Anthropology, Harvard University, Cambridge, Massachusetts, USA
P. T. Ellison
Affiliation:
Department of Anthropology, Harvard University, Cambridge, Massachusetts, USA

Summary

Daily luteal progesterone levels were measured for 124 regularly menstruating women, aged 18–44, by radioimmunoassay of steroid levels in saliva. A consistent pattern of age variation in luteal function was found, with the lowest levels of progesterone in the 18–19-year-old and 40–44-year-old groups, the highest values in the 25–34 year olds, and intermediate values in the 20–24 and 35–39-year-old groups. The striking similarity of this pattern of age variation with empirically and theoretically generated curves of apparent fecundability, suggests that age-related changes in ovarian function may underlie observed age variation in fecundability.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1992

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References

After, D. & Vihko, R. (1983) Early menarche, a risk factor for breast cancer, indicates early onset of ovulatory cycles. J. din. Endocr. Metab. 57, 82.Google Scholar
After, D., Vhnikka, L. & Vihko, R. (1978) Hormonal pattern of adolescent menstrual cycles. J. din. Endocr. Metab. 47, 944.Google Scholar
Collect, M. E., Wertenberger, G. E. & Fiske, V. M. (1954) The effect of age upon the pattern of the menstrual cycle. Pert. Steril. 5, 437.CrossRefGoogle Scholar
Connor, M. L., Sanford, L. M. & Howland, B. E. (1982) Saliva progesterone throughout the menstrual cycle and late pregnancy. Can. J. Physiol. Pharmac. 60, 410.CrossRefGoogle ScholarPubMed
Doring, G. K. (1969) The incidence of anovular cycles in women. J. Reprod. Pert. Suppl. 6, 77.Google Scholar
Dunphy, B. C., Li, T-C, Macleod, I. C, Barract, C. L. R., Lenton, E. A. & Cooke, I. D. (1990) The interaction of parameters of male and female fertility in couples with previously unexplained fertility. Pert. Steril. 54, 824.CrossRefGoogle Scholar
Edvinsson, A., Forssman, L., Milsom, I. & Nordfors, G. (1990) Factors in the infertile couple influencing the success of artificial insemination with donor semen. Fert. Steril. 53, 81.CrossRefGoogle ScholarPubMed
Ellison, P. T. (1988) Human salivary steroids: methodological considerations and applications in physical anthropology. Yearb. phys. Anthrop. 31, 115.CrossRefGoogle Scholar
Ellison, P. T., Lager, C. & Calfee, J. (1987) Low profiles of salivary progesterone among college undergraduate women. J. adolesc. Hlth Care, 8, 204.CrossRefGoogle ScholarPubMed
Ellison, P. T., Peacock, N. R. & Lager, C. (1986) Salivary progesterone and luteal function in two low-fertility populations of northeast Zaire. Hum. Biol. 58, 473.Google ScholarPubMed
Ellison, P. T., Peacock, N. R. & Lager, C. (1989) Ecology and ovarian function among Lese women of the Ituri Forest, Zaire. Am. J. phys. Anthrop. 78, 519.CrossRefGoogle ScholarPubMed
Federation, Cecos, Schwartz, D. & Mayaux, M. J. (1982) Female fecundity as a function of age. N. Engl. J. Med. 306, 404.CrossRefGoogle Scholar
Fritz, M. A. (1988) Inadequate luteal function and recurrent abortion: diagnosis and treatment of luteal phase deficiency. Semin. reprod. Endocr. 6, 129.CrossRefGoogle Scholar
Gardner, J. (1983) Adolescent menstrual characteristics as predictors of gynaecological health. Ann. hum. Biol. 10, 31.CrossRefGoogle ScholarPubMed
Gibori, G., Antczak, E. & Rothchild, I. (1977) The role of estrogen in the regulation of luteal progesterone secretion in the rat after day 12 of pregnancy. Endocrinology. 100, 1483.CrossRefGoogle ScholarPubMed
Gidley-Baird, A. A., Oneill, C., Sinosich, M. J., Porter, R. N., Pike, I. L. & Saunders, D. M. (1986) Failure of implantation in human in vitro fertilization and embryo transfer patients: the effects of altered progesterone/estrogen ratios in humans and mice. Fert. Steril. 45, 69.CrossRefGoogle Scholar
Gray, R. H. (1979) Biological and social interactions in the determination of late fertility. J. biosoc. Sci. Suppl. 6, 97.CrossRefGoogle Scholar
Henry, L. (1961) Some data on natural fertility. Eugen. Q. 8, 81.CrossRefGoogle ScholarPubMed
Jain, A. T., Hsu, C., Freedman, R. & Chang, M. C. (1970) Demographic aspects of lactation and postpartum amenorrhea. Demography, 7, 255.CrossRefGoogle Scholar
James, W. H. (1983) Decline in coital rates with spouses' ages and duration of marriage, J. biosoc. Sci. 15, 83.CrossRefGoogle ScholarPubMed
Jones, R. E. (1988) A hazards model analysis of breastfeeding variables and maternal age on return to menses postpartum in rural Indonesian women. Hum. Biol. 60, 853.Google ScholarPubMed
Lenton, E. A., Gelsthorp, C. H. & Harper, R. (1988) Measurement of progesterone in saliva: assessment of the normal fertile range using spontaneous conception cycles. Clin. Endocr. 38, 637.CrossRefGoogle Scholar
Lenton, E. A., Landgren, B-M. & Sexton, L. (1984a) Normal variation in the length of the luteal phase of the menstrual cycle: identification of the short luteal phase. Br. J. Obstet. Gynaec. 91, 685.CrossRefGoogle ScholarPubMed
Lenton, E. A., Landgren, B-M., Sexton, L. & Harper, R. (1984b) Normal variation in the length of the follicular phase of the menstrual cycle: effect of chronological age. Br. J. Obstet. Gynaec. 91, 681.CrossRefGoogle ScholarPubMed
Lipson, S. F. & Ellison, P. T. (1989) Development of protocols for the application of salivary steroid analyses to field conditions. Am. J. hum. Biol. 1, 249.CrossRefGoogle Scholar
Liu, H. C., Jones, G. S., Jones, H. W. JR. & Rosenwaks, Z. (1988) Mechanisms and factors of early pregnancy wastage in in vitro fertilization–embryo transfer patients. Fert. Steril. 50, 95.CrossRefGoogle ScholarPubMed
Maslar, I. A. (1988) The progestational endometrium. Semin. reprod. Endocr. 6, 115.CrossRefGoogle Scholar
Menken, J., Trussell, J. & Larsen, U. (1986) Age and infertility. Science, N.Y. 233, 1389.CrossRefGoogle ScholarPubMed
Metcalf, M. G., Donald, R. A. & Livesey, J. H. (1981) Classification of menstrual cycles in preand perimenopausal women. J. Endocr. 91, 1.CrossRefGoogle Scholar
Metcalf, M. G. & Mackenzie, J. A. (1980) Incidence of ovulation in young women. J. biosoc. Sci. 12, 345.CrossRefGoogle ScholarPubMed
Metcalf, M. G., Skidmore, D. S., Lowry, G. F. & Mackenzie, J. A. (1983) Incidence of ovulation in the years after the menarche. J. Endocr. 97, 213.CrossRefGoogle ScholarPubMed
Metropolitan Life Insurance Company (1983) 1983 Metropolitan height and weight tables. Statist. Bull. 64, 2.Google Scholar
O'Rourke, M. T. & Ellison, P. T. (1990) Salivary measurement of episodic progesterone release. Am. J. phys. Anthrop. 81, 423.CrossRefGoogle ScholarPubMed
Read, G. F., Wilson, D. W., Hughes, I. A. & Griffiths, K. (1984) The use of salivary progesterone assays in the assessment of ovarian function in postmenarcheal girls. J. Endocr. 102, 265CrossRefGoogle ScholarPubMed
Sauer, M. V., Paulson, R. J. & Lobo, R. A. (1990) A preliminary report on oocyte donation extending reproductive potential to women over 40. N. Engl. J. Med. 323, 1157.CrossRefGoogle ScholarPubMed
Schweiger, U., Laessle, R., Pfister, H., Hoehl, C, Schwingenschloegel, M., Schweiger, M. & Pirke, K-M. (1987) Diet-induced menstrual irregularities: effects of age and weight loss. Fen. Steril. 48, 746.CrossRefGoogle ScholarPubMed
Selvin, S. & Garfinkel, J. (1976) Paternal age, maternal age, and birth order and risk of fetal loss. Hum. Biol. 48, 223.Google ScholarPubMed
Sherman, B. M. & Korenman, S. G. (1975) Hormonal characteristics of the human menstrual cycle throughout reproductive life. J. din. Invest. 55, 699.Google ScholarPubMed
Stouffer, R. L. (1988) Perspectives on the corpus luteum of the menstrual cycle and early pregnancy. Semin. reprod. Endocr. 6, 103.CrossRefGoogle Scholar
Treloar, A. E., Boynton, R. E., Behn, B. G. & Brown, B. W. (1967) Variation of the human menstrual cycle through reproductive life. Int. J. Pert. 12, 77.Google ScholarPubMed
Venturoli, S., Porcu, E., Fabbri, R., Magrini, O., Paradisi, R., Pallotti, G., Gammi, L. & Famigni, C. (1987) Postmenarchal evolution of endocrine pattern and ovarian aspects in adolescents with menstrual irregularities. Pert. Steril. 48, 78.CrossRefGoogle ScholarPubMed
Vihko, R. & Apter, D. (1984) Endocrine characteristics of adolescent menstrual cycles: impacts of early menarche. J. steroid Biochem. 20, 231.CrossRefGoogle ScholarPubMed
Virro, M. R. & Shewchuk, A. B. (1984) Pregnancy outcome in 242 conceptions after artificial insemination with donor sperm and effects of maternal age on the prognosis for successful pregnancy. Am. J. Obstet. Gynec. 148, 518.CrossRefGoogle ScholarPubMed
Vuorento, T., Hovatta, O., Kurunmaki, H., Ratsula, K. & Huhtaniemi, I. (1990) Measurements of salivary progesterone throughout the menstrual cycle in women suffering from unexplained infertility reveal high frequency of luteal phase defects. Pert. Steril. 54, 211.CrossRefGoogle ScholarPubMed
Vuorento, T., Lahti, A., Hovatta, O. & Huhtaniemi, I. (1989) Daily measurements of salivary progesterone reveal a high rate of anovulation in healthy students. Scand. J. din. Lab. Invest. 49, 395.CrossRefGoogle ScholarPubMed
Weinstein, M., Wood, J. W., Stoto, M. A. & Greenfield, D. D. (1990) Components of agespecific fecundability. Popul. Stud. 44, 447.CrossRefGoogle Scholar
Wood, J. W. (1989) Fecundity and natural fertility in humans. Oxf. Rev. reprod. Biol. 11, 61.Google ScholarPubMed
Wood, J. W. & Weinstein, M. (1988) A model of age-specific fecundability. Popul. Stud. 42, 85.CrossRefGoogle Scholar
Yoshimura, Y. & Wallach, E. E. (1987) Studies of the mechanism(s) of mammalian ovulation. Pert. Steril. 47, 22.CrossRefGoogle ScholarPubMed