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A pilot study: Using computational fluid dynamics to model physiologic airflow through an ovine tissue engineered tracheal graft

Published online by Cambridge University Press:  10 May 2018

Nakesha King ,
Victoria Pepper ,
Cameron Best ,
Ekene Onwuka ,
Chengyu Li ,
Eric Heuer ,
Jed Johnson ,
Kai Zhao ,
Christopher K. Breuer  and
Tendy Chiang
Nakesha King
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Victoria Pepper
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Cameron Best
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Ekene Onwuka
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Chengyu Li
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Eric Heuer
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Jed Johnson
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Kai Zhao
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Christopher K. Breuer
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
Tendy Chiang
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
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Abstract

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OBJECTIVES/SPECIFIC AIMS: Tissue engineered tracheal grafts (TETG) could provide a life-saving cure for children with long segment airway defects. Computational fluid dynamics (CFD) is a novel and promising technique used to evaluate TETG performance. This pilot study examines the correlation of objective CFD simulations with subjective respiratory symptoms in a TETG large animal model. METHODS/STUDY POPULATION: Three-dimensional geometries of 1 TETG implanted sheep trachea were reconstructed from serial fluoroscopic images, allowing analysis with CFD simulations. Peak flow velocity (PFV) and peak wall shear stress (PWSS) across the graft as well as changes secondary to stenting were determined. CFD metrics were compared with respiratory symptoms seen on exam. RESULTS/ANTICIPATED RESULTS: Two weeks after implantation, the animal developed respiratory distress, which correlated with PFV and PWSS elevations. Although the intraluminal graft appearance changed minimally after dilation, PFV and PWSS decreased across the graft (4.5–0.8 m/s and 0.9–0.1 Pa, respectively). Long-term TETG stenting with dilation returned PFV and PWSS to baseline (0.8–0.3 m/s and 0.1–0.01 Pa, respectively), which correlated with immediate symptom resolution. DISCUSSION/SIGNIFICANCE OF IMPACT: CFD is a noninvasive modality, which allows the evaluation of airflow metrics of symptomatic TETG recipients. This diagnostic tool will permit planned interventions and graft design optimization.

Type
Mechanistic Basic to Clinical
Information
Journal of Clinical and Translational Science , Volume 1 , Supplement S1 , September 2017 , pp. 65
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Association for Clinical and Translational Science 2018