Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-10T12:20:02.945Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparison between two preventive treatments for hyperketonaemia carried out pre-partum: effects on non-esterified fatty acids, β-hydroxybutyrate and some biochemical parameters during peripartum and early lactation

Published online by Cambridge University Press:  17 February 2021

Enrico Fiore ,
Laura Perillo ,
Matteo Gianesella ,
Claudia Giannetto ,
Elisabetta Giudice ,
Giuseppe Piccione  and
Massimo Morgante
Enrico Fiore
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 16, 35020Legnaro (PD), Italy
Laura Perillo
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Matteo Gianesella
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 16, 35020Legnaro (PD), Italy
Claudia Giannetto
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Elisabetta Giudice
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Giuseppe Piccione*
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Massimo Morgante
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 16, 35020Legnaro (PD), Italy
*
Author for correspondence: Giuseppe Piccione, Email: gpiccione@unime.it
Get access Rights & Permissions [Opens in a new window]

Abstract

The objective of this study was to compare the effect of two different preventive protocols, on serum β-hydroxybutyrate (BHB) concentration and liver health indices pre-partum and during early-lactation in high-yielding Holstein dairy cows. One hundred cows were randomly divided into three groups: control group (CTRL, n = 20, without preventive treatment), second group (SUPP, n = 40 animals treated with a compound based on acetyl-methionine, inositol, cyanocobalamin, l-alanine, l-arginine, l-threonine, l-glutamic acid supplementation and α-lipoic acid) and third group (MON, n = 40 animals treated with monensin). Blood samples were collected from all cows at on 3 occasions pre-partum and 3 occasions post-partum. Body condition (BCS) score was evaluated and glucose, non-esterified fatty acids (NEFA), BHB, triglycerides, total cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), total bilirubin, total proteins, globulins, albumin and urea concentrations were assessed. Two-way repeated measures analysis of variance was applied. Statistically significant differences among the three experimental groups were found in the values of all studied parameters (P < 0.05). Our results confirm the established beneficial effect of MON treatment in decreasing BHB levels and increasing glucose availability after calving. Serum biochemical analysis revealed the expected post-partum alterations attributable to adaptations that influenced the metabolism and liver function in CTRL, whereas these alterations were reduced or absent in SUPP and MON. Results from the present study suggest that both preventive protocols, but in particular SUPP, could positively affect selected indicators of energy metabolism reducing the risk of hyperketonaemia and increase of liver function in Holstein dairy cows, both pre- and post-partum.

Keywords

Cowhyperketonaemialactationliversupplementation
Type
Research Article
Information
Journal of Dairy Research , Volume 88 , Issue 1 , February 2021 , pp. 38 - 44
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of Hannah Dairy Research Foundation

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Akiba, S, Matsugo, S, Packer, L and Konishi, T (1998) Assay of protein-bound lipoic acid in tissues by a new enzymatic method. Analytical Biochemistry 258, 299–304.CrossRefGoogle ScholarPubMed
Akins, MS, Bertics, SJ, Socha, MT and Shaver, RD (2013) Effects of cobalt supplementation and vitamin B12 injections on lactation performance and metabolism of Holstein dairy cows. Journal of Dairy Science 96, 1755–1768.CrossRefGoogle ScholarPubMed
Arfuso, F, Fazio, F, Levanti, M, Rizzo, M, Di Pietro, S, Giudice, E and Piccione, G (2016) Lipid and lipoprotein profile changes in dairy cows in response to late pregnancy and the early postpartum period. Archives Animal Breeding 59, 429–434.CrossRefGoogle Scholar
Bell, AW (1995) Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. Journal of Animal Science 73, 2804–2819.CrossRefGoogle ScholarPubMed
Bobbo, T, Fiore, E, Gianesella, M, Morgante, M, Gallo, L, Ruegg, PL, Bittante, G and Cecchinato, A (2017) Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds. Animal 11, 2309–2319.CrossRefGoogle ScholarPubMed
Bobe, G, Young, JW and Beitz, DC (2004) Invited review: pathology, etiology, prevention, and treatment of fatty liver in dairy cows. Journal of Dairy Science 87, 3105–3124.CrossRefGoogle ScholarPubMed
Brask-Pedersen, DN, Glitsø, LV, Skov, LK, Lund, P and Sehested, J (2013) Effect of exogenous phytase on degradation of inositol phosphate in dairy cows. Journal of Dairy Science 96, 1691–1700.CrossRefGoogle ScholarPubMed
Bustamante, J, Lodge, JK, Marcocci, L, Tritschler, HJ, Packer, L and Rihn, BH (1998) Alpha-lipoic acid in liver metabolism and disease. Free Radical Biology and Medicine 24, 1023–1039.CrossRefGoogle ScholarPubMed
Cozzi, G, Ravarotto, L, Gottardo, F, Stefani, L, Contiero, B, Moro, L, Brscic, M and Dalvit, P (2011) Short communication: reference values for blood parameters in Holstein dairy cows: effects of parity, stage of lactation, and season of production. Journal of Dairy Science 94, 3895–3901.CrossRefGoogle Scholar
Drong, C, Meyer, U, von Soosten, D, Frahm, J, Rehage, J, Breves, G and Dänicke, S (2016) Effect of monensin and essential oils on performance and energy metabolism of transition dairy cows. Journal of Animal Physiology and Animal Nutrition 100, 537–351CrossRefGoogle ScholarPubMed
Duffield, TF, LeBlanc, S, Bagg, R, Leslie, KE, Ten Hag, J and Dick, P (2003) Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. Journal of Dairy Science 86, 1171–1176.CrossRefGoogle ScholarPubMed
Duffield, TF, Rabiee, AR and Lean, IJ (2008) A meta-analysis of the impact of Monensin in lactating dairy cattle. Part 1. Metabolic effects. Journal of Dairy Science 91, 1334–1346.CrossRefGoogle ScholarPubMed
Duplessis, M, Lapierre, H, Pellerin, D, Laforest, JP and Girard, CL (2017) Effects of intramuscular injections of folic acid, vitamin B12, or both, on lactational performance and energy status of multiparous dairy cows. Journal of Dairy Science 100, 4051–4064.CrossRefGoogle ScholarPubMed
Edmondson, AJ, Lean, D, Weaver, ID, Farver, T and Webster, G (1989) A body condition scoring chart for Holstein dairy cows. Journal of Dairy Science 72, 68–78.CrossRefGoogle Scholar
Fiore, E, Perillo, L, Piccione, G, Gianesella, M, Bedin, S, Armato, L, Giudice, E and Morgante, M (2016) Effect of combined acetylmethionine, cyanocobalamin and α-lipoic acid on hepatic metabolism in high-yielding dairy cow. Journal of Dairy Research 83, 438–441.CrossRefGoogle ScholarPubMed
Fiore, E, Piccione, G, Perillo, L, Barberio, A, Manuali, E, Morgante, M and Gianesella, M (2017) Hepatic lipidosis in high-yielding dairy cows during the transition period: haematochemical and histopathological findings. Animal Production Science 57, 74–80.CrossRefGoogle Scholar
Fürll, M, Deniz, A, Westphal, B, Illing, C and Constable, PD (2010) Effect of multiple intravenous injections of butaphosphan and cyanocobalamin on the metabolism of periparturient dairy cows. Journal of Dairy Science 93, 4155–4164.CrossRefGoogle Scholar
Gianesella, M, Perillo, L, Fiore, E, Giudice, E, Zumbo, A, Morgante, M and Piccione, G (2018) Transition period in healthy and diseased dairy cows: evaluation of metabolic modifications. Large Animal Review 24, 107–111.Google Scholar
González, FD, Muiño, R, Pereira, V, Campos, R and Benedito, JL (2011) Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows. Journal of Veterinary Science 12, 251–255.CrossRefGoogle ScholarPubMed
Gorąca, A, Huk-Kolega, H, Piechota, A, Kleniewska, P, Ciejka, E and Skibska, B (2011) Lipoic acid – biological activity and therapeutic potential. Pharmacological Reports 63, 849–858.CrossRefGoogle ScholarPubMed
Gordon, JL, Leblanc, SJ and Duffield, TF (2013) Ketosis treatment in lactating dairy cattle. Veterinary Clinics of North America: Food and Animal Practice 29, 433–445.Google ScholarPubMed
Graulet, B, Matte, JJ, Desrochers, A, Doepel, L, Palin, MF and Girard, CL (2007) Effects of dietary supplements of folic acid and vitamin B12 on metabolism of dairy cows in early lactation. Journal of Dairy Science 90, 3442–3455.CrossRefGoogle ScholarPubMed
Indyk, HE, Saldo, SC, White, PM, Dole, MN, Gill, BD and Woollard, DC (2016) The free and total myo-inositol contents of early lactation and seasonal bovine milk. International Dairy Journal 56, 33–37.CrossRefGoogle Scholar
McCarthy, MM, Yasui, T, Ryan, CM, Pelton, SH, Mechor, GD and Overton, TR (2015) Metabolism of early-lactation dairy cows as affected by dietary starch and monensin supplementation. Journal of Dairy Science 98, 3351–3365.CrossRefGoogle ScholarPubMed
Melendez, P, Goff, JP, Risco, CA, Archbald, LF, Littell, R and Donovan, GA (2006) Incidence of subclinical ketosis in cows supplemented with a monensin controlled-release capsule in Holstein cattle, Florida, USA. Preventative Veterinary Medicine 73, 33–42.CrossRefGoogle ScholarPubMed
Mullins, CR, Mamedova, LK, Brouk, MJ, Moore, CE, Green, HB, Perfield, KL, Smith, JF, Harner, JP and Bradford, BJ (2012) Effects of monensin on metabolic parameters, feeding behavior, and productivity of transition dairy cows. Journal of Dairy Science 95, 1323–1336.CrossRefGoogle ScholarPubMed
Odongo, NE, Or-Rashid, MM, Bagg, R, Vessie, G, Dick, P, Kebreab, E, France, J and McBride, BW (2007) Long-term effects of feeding monensin on milk fatty acid composition in lactating dairy cows. Journal of Dairy Science 90, 5126–5133.CrossRefGoogle ScholarPubMed
Pereira, RA, Fensterseifer, S, Barcelos, VB, Martins, CF, Schneider, A, Schmitt, E, Pfeifer, LFM, Del Pino, FAB and Corrêa, MN (2013) Metabolic parameters and dry matter intake of ewes treated with butaphosphan and cyanocobalamin in the early postpartum period. Small Ruminant Research 114, 140–145.CrossRefGoogle Scholar
Piccione, G, Messina, V, Schembari, A, Casella, S, Giannetto, C and Alberghina, D (2011) Pattern of serum protein fractions in dairy cows during different stages of gestation and lactation. Journal of Dairy Research 78, 421–425.CrossRefGoogle ScholarPubMed
Preynat, A, Lapierre, H, Thivierge, MC, Palin, MF, Matte, JJ, Desrochers, A and Girard, CL (2009) Influence of methionine supply on the response of lactational performance of dairy cows to supplementary folic acid and vitamin B12. Journal of Dairy Science 92, 1685–1695.CrossRefGoogle ScholarPubMed
Rafia, S, Taghipour-Bazargani, T, Asadi, F, Vajhi, A and Bokaie, S (2012) Evaluation of the correlation between serum biochemical values and liver ultrasonographic indices in periparturient cows with different body condition scores. American Journal of Veterinary Research 73, 830–837.CrossRefGoogle ScholarPubMed
Rollin, E, Berghaus, RD, Rapnicki, P, Godden, SM and Overton, MW (2010) The effect of injectable butaphosphan and cyanocobalamin on postpartum serum β-hydroxybutyrate, calcium, and phosphorus concentrations in dairy cattle. Journal of Dairy Science 93, 978–987.CrossRefGoogle ScholarPubMed
Zhou, Z, Loor, JJ, Piccioli-Cappelli, F, Librandi, F, Lobley, GE and Trevisi, E (2016) Circulating amino acids in blood plasma during the peripartal period in dairy cows with different liver functionality index. Journal of Dairy Science 99, 2257–2267.CrossRefGoogle ScholarPubMed
Zhou, Z, Vailati-Riboni, M, Luchini, DN and Loor, JJ (2017) Methionine and choline supply during the periparturient period alter plasma amino acid and one-carbon metabolism profiles to various extents: potential role in hepatic metabolism and antioxidant Status. Nutrients 29, pii: E10.Google Scholar
Supplementary material: PDF

Fiore et al. supplementary material

Fiore et al. supplementary material

Download Fiore et al. supplementary material(PDF)
PDF 471.9 KB