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Calcium-enriched goats' milk aids recovery of iron status better than calcium-enriched cows' milk, in rats with nutritional ferropenic anaemia

Published online by Cambridge University Press:  12 May 2008

Teresa Nestares ,
Mercedes Barrionuevo ,
Javier Díaz-Castro ,
Inmaculada López-Aliaga ,
Ma José M Alférez  and
Margarita S Campos
Teresa Nestares
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Mercedes Barrionuevo
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Javier Díaz-Castro
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Inmaculada López-Aliaga
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Ma José M Alférez
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Margarita S Campos*
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
*
*For correspondence; e-mail: marga@ugr.es
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Abstract

Ca-Fe interactions are known, but no studies are available about the effects of Ca-enriched goat or cow milk on Fe status in nutritional ferropenic anaemia (NFA). To examine this matter, control and Fe-deficient rats were fed for 14 d with goat or cow milk diets containing either normal or high Ca content (5000 or 10 000 mg/kg diet), and different indices and parameters related to iron status were measured. The apparent digestibility coefficient (ADC) and the Fe retention/intake (R/I) ratio were higher in control and anaemic rats fed goat milk diet (G diet), despite high-Ca content. Ca enrichment decreased Fe stores in liver and sternum in anaemic rats fed cow milk diet (C diet), however G diet did not modify Fe content in the organs studied in control and anaemic rats. In anaemic rats, Ca-supplementation decreased haematocrit, but platelets and serum Fe were not affected, however, in control rats platelets increased except for Ca-enriched G diet, this fact reveals that Ca-Fe interaction is minimized with G diet. Serum ferritin was always higher in rats fed G vs. C diet, both in control and anaemic rats fed either normal or Ca-enriched diets. Ca-supplementation decreased ferritin levels in control and anaemic rats fed C diet and also, though to a lesser extent, in those given the G diet. This indicates that with this G diet there is a better recovery of body Fe stores in anaemic rats, despite Ca-supplementation. In this study it is noteworthy that despite high Ca content, a goat milk diet resulted in minimal Ca-Fe interactions and did not adversely affect Fe status in rats with NFA.

Keywords

Goat and cow milkcalcium enrichmentanaemiairon status
Type
Research Article
Information
Journal of Dairy Research , Volume 75 , Issue 2 , May 2008 , pp. 153 - 159
Copyright
Copyright © Proprietors of Journal of Dairy Research 2008

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