Hostname: page-component-745bb68f8f-cphqk Total loading time: 0 Render date: 2025-01-13T02:31:40.605Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of combined acetylmethionine, cyanocobalamin and α-lipoic acid on hepatic metabolism in high-yielding dairy cow

Published online by Cambridge University Press:  15 November 2016

Enrico Fiore ,
Laura Perillo ,
Giuseppe Piccione ,
Matteo Gianesella ,
Silvia Bedin ,
Leonardo Armato ,
Elisabetta Giudice  and
Massimo Morgante
Enrico Fiore
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Laura Perillo
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Giuseppe Piccione*
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Matteo Gianesella
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Silvia Bedin
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Leonardo Armato
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Elisabetta Giudice
Affiliation:
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166, S. Agata-Messina, Italy
Massimo Morgante
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
*
*For correspondence; e-mail: gpiccione@unime.it
Get access Rights & Permissions [Opens in a new window]

Abstract

The aim of the study reported in this Research Communication was to investigate the effect of a combined acetylmethionine, cyanocobalamin and α-lipoic acid treatment, on some metabolic parameters of early lactating high-yielding dairy cows. Thirty cows were randomly divided into two groups: experimental group (EG, n = 20) and control group (CG, n = 10). EG received 20 ml of treatment and CG received 20 ml of placebo. The treatments were administered for seven times every 2 d. Blood samples were collected from all cows at 3 time points: 10 ± 2, 30 ± 2 and 50 ± 2 d postpartum. Glucose, β-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), triglycerides, total cholesterol (TC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamiltransferase (GGT), total bilirubin (TB), conjugated bilirubin (CB), total proteins (TP), globulins, albumin and urea concentrations were determined. Two-way repeated measure analysis of variance was applied. Significant differences in the values of glucose, BHB, NEFA, triglycerides, TC, AST and urea were found between EG and CG. Moreover, the increased glucose, TC, ALT, GGT, TP and globulins, and the reduced BHB, NEFA, AST, triglycerides, TB, CB and urea concentrations were evident in both groups, but the changes were more pronounced in EG. Our findings indicate that our treatment positively influenced liver metabolism in high-yielding dairy cows.

Keywords

Acetylmethioninecyanocobalaminα-lipoic acidlivercow
Type
Research Article
Information
Journal of Dairy Research , Volume 83 , Issue 4 , November 2016 , pp. 438 - 441
Copyright
Copyright © Proprietors of Journal of Dairy Research 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Duffield, TF, LeBlanc, S, Bagg, R, Leslie, K, Ten Hag, J & Dick, P 2003 Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. Journal of Dairy Science 86 1171–1176 Google Scholar
Edmonson, AJ, Lean, IJ, Weaver, LD, Farver, T & Webster, G 1989 A body condition scoring chart for Holstein dairy cows. Journal of Dairy Science 72 68–78 Google Scholar
Fiore, E, Gianesella, M, Arfuso, F, Giudice, E, Piccione, G, Lora, M, Stefani, A & Morgante, M 2014 Glucose infusion response on some metabolic parameters in dairy cows during transition period. Archiv Tierzucht 57 1–9 Google Scholar
Fürll, M, Deniz, A, Westphal, B, Illing, C & Constable, PD 2010 Effect of multiple intravenous injections of butaphosphan and cyanocobalamin on the metabolism of periparturient dairy cows. Journal of Dairy Science 93 4155–4164 Google Scholar
Kreipe, L, Deniz, A, Bruckmaier, RM & van Dorland, HA 2011 First report about the mode of action of combined butafosfan and cyanocobalamin on hepatic metabolism in nonketotic early lactating cows. Journal of Dairy Science 94 4904–4914 Google Scholar
Nielsen, NI & Ingvartsen, KL 2004 Propylene glycol for dairy cows A review of the metabolism of propylene glycol and its effects on physiological parameters, feed intake, milk production and risk of ketosis. Animal Feed Science and Technology 115 191–213 Google Scholar
Piccione, G, Messina, V, Marafioti, S, Casella, S, Giannetto, C & Fazio, F 2012 Changes of some haematochemical parameters in dairy cows during late gestation, post partum, lactation and dry periods. Veterinarija Ir Zootechnika 58 59–64 Google Scholar
Preynat, A, Lapierre, H, Thivierge, MC, Palin, MF, Matte, JJ, Desrochers, A & Girard, CL 2009 Influence of methionine supply on the response of lactational performance of dairy cows to supplementary folic acid and vitamin B12. Journal of Dairy Science 92 1685–1695 Google Scholar
Roubies, N, Panouis, N, Fytianou, A, Katsoulos, PD, Giadinis, N & Karatzias, H 2006 Effects of age and reproductive stage on certain serum biochemical parameters of Chios sheep under greek rearing conditions. Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine 53 277–281 Google Scholar
Stojević, Z, Piršljin, J, Milinković-Tur, S, Zdelar-Tuk, M & Ljubić, BB 2005 Activities of AST, ALT and GGT in clinically healthy dairy cows during lactation and in the dry period. Veterinarski Arhiv 75 67–73 Google Scholar
Supplementary material: PDF

Fiore supplementary material

Table S1

Download Fiore supplementary material(PDF)
PDF 201.5 KB