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Effect of penethamate hydriodide treatment on bacteriological cure, somatic cell count and milk production of cows and quarters with chronic subclinical Streptococcus uberis or Streptococcus dysgalactiae infection

Published online by Cambridge University Press:  16 October 2003

Suzanne G St.Rose ,
Jantijn M Swinkels ,
Wim DJ Kremer ,
Cas LJJ Kruitwagen  and
Ruth N Zadoks
Suzanne G St.Rose
Affiliation:
Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands Current address: Department of Food Science, 401 Stocking Hall, Cornell University, Ithaca NY 14853-7201, USA.
Jantijn M Swinkels
Affiliation:
Veterinary Practice VEO, Sluisweg 3, 1474 HL Oosthuizen, The Netherlands
Wim DJ Kremer
Affiliation:
Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands
Cas LJJ Kruitwagen
Affiliation:
Centre for Biostatistics, Utrecht University, Padualaan 14, 3584 CH Utrecht, The Netherlands
Ruth N Zadoks
Affiliation:
Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands Current address: Centre for Tropical Veterinary Medicine, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, Scotland EH25 9RG, UK.
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Abstract

A randomized, controlled field trial was performed in The Netherlands to determine the therapeutic efficacy of parenteral penethamate hydriodide (Leocillin®) against naturally occurring, chronic, streptococcal mastitis during lactation. Quarter milk samples were collected from subclinical cases of Streptococcus uberis or Streptococcus dysgalactiae mastitis to determine the effect of treatment on bacteriological cure and somatic cell count (SCC) at quarter level. A quarter was considered to be cured when the bacterial species, isolated prior to treatment, was not isolated from the quarter milk samples taken on days 10 and 20 post-treatment (bacteriological cure), or when a quarter milk SCC (QMSCC) was <250000 cells/ml on days 10 and 20 post-treatment (SCC cure). Longitudinal data analysis was performed to determine the effect of antibiotic therapy on SCC and milk yield at cow level. Bacteriological cure occurred in 59% of 29 treated quarters, while no cure was observed in any of the 21 untreated control quarters. Treatment resulted in a significant decrease in SCC at cow and quarter level in comparison with untreated controls. There was no significant effect of treatment on milk production. Antibacterial treatment of subclinical streptococcal infections during lactation also prevented clinical mastitis. Furthermore, the treatment may contribute to reduction of bulk milk SCC and to prevention of pathogen spread in dairy herds.

Keywords

Mastitisantibioticparenteral
Type
Research Article
Information
Journal of Dairy Research , Volume 70 , Issue 4 , November 2003 , pp. 387 - 394
Copyright
© Proprietors of Journal of Dairy Research 2003

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