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Effects of dietary supplementation of pioglitazone or walnut meal on metabolic profiles and oxidative status in dairy cows with high pre-calving BCS

Published online by Cambridge University Press:  22 February 2018

Negin Jamali Emam Gheise ,
Ahmad Riasi ,
Pietro Celi  and
Ahmad Zare Shahneh
Negin Jamali Emam Gheise
Affiliation:
Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, POB: 84156-83111, Iran
Ahmad Riasi
Affiliation:
Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, POB: 84156-83111, Iran
Pietro Celi*
Affiliation:
DSM Nutritional Products, Columbia, MD, USA Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Vic. 3010, Australia
Ahmad Zare Shahneh
Affiliation:
Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran
*
*For correspondence; e-mail: pietro.celi@dsm.com
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Abstract

This research paper addresses the hypothesis that dietary pioglitazone (PGT), as synthetic and specific ligand for PPAR-γ or walnut meal (WM) as a natural ligand for PPAR-γ, affect plasma metabolites and reduce the oxidative status in high body condition score (BCS) dairy cows (≥4 BCS). Total of 36 multiparous Holstein cows were randomly assigned to one of the dietary treatments: 1- Control (basal diet; CTR), 2- Walnut meal (9·45% walnut meal of DMI; WM), and 3- Pioglitazone (6 mg/kg BW; PGT). The experimental diets were fed from parturition time to 21 d postpartum. Results showed that the PGT supplementation increased dry matter intake (DMI) (22·95 kg/d) compared to the CTR (21·45 kg/d) and WM (21·78 kg/d) groups. Results showed that milk yield and milk composition were not affected by the experimental diets. Body condition score losses tended to be higher in the CTR group compared to the PGT and WM cows. The PGT group had higher plasma insulin compared to the CTR group (11·84 vs. 10·68 mIU/l), and WM cows had intermediate plasma insulin. The PGT cows had lower plasma non esterified fatty acid (NEFA) and tended to have lower β-hydroxy butyric acid (BHBA) than the CTR group. Feeding pioglitazone decreased plasma malondialdehyde (MDA) and increased plasma total antioxidant capacity (TAC) and superoxide dismutase (SOD) compared to the CTR and WM groups. It was concluded that dietary pioglitazone had positive effects on DMI, BCS change, blood metabolites and oxidative status in fresh dairy cows with high pre-calving BCS. The anti-oxidant effects of walnut meal were not supported by the present data.

Keywords

Pioglitazonewalnut mealblood metaboliteoxidative statusfat cow
Type
Research Article
Information
Journal of Dairy Research , Volume 85 , Issue 1 , February 2018 , pp. 16 - 22
Copyright
Copyright © Hannah Dairy Research Foundation 2018 

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