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Evaluation of breed-dependent differences in the innate immune responses of Holstein and Jersey cows to Staphylococcus aureus intramammary infection

Published online by Cambridge University Press:  04 August 2008

Douglas D Bannerman ,
Hayley R Springer ,
Max J Paape ,
Adam CW Kauf  and
Jesse P Goff
Douglas D Bannerman*
Affiliation:
Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville MD 20705, USA
Hayley R Springer
Affiliation:
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames IA 50010, USA
Max J Paape
Affiliation:
Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville MD 20705, USA
Adam CW Kauf
Affiliation:
Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville MD 20705, USA
Jesse P Goff
Affiliation:
Periparturient Diseases of Cattle Research Unit, National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames IA 50010, USA
*
*For correspondence; e-mail: douglas.bannerman@ars.usda.gov
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Abstract

Mastitis is one of the most prevalent diseases of cattle. Various studies have reported breed-dependent differences in the risk for developing this disease. Among two major breeds, Jersey cows have been identified as having a lower prevalence of mastitis than Holstein cows. It is well established that the nature of the initial innate immune response to infection influences the ability of the host to clear harmful bacterial pathogens. Whether differences in the innate immune response to intramammary infections explain, in part, the differential prevalence of mastitis in Holstein and Jersey cows remains unknown. The objective of the current study was to evaluate several parameters of the innate immune response of Holstein and Jersey cows to intramammary infection with Staphylococcus aureus, a common mastitis-inducing pathogen. To control for non-breed related factors that could influence these parameters, all cows were of the same parity, in similar stages of milk production, housed and managed under identical conditions, and experimentally infected and sampled in parallel. The following parameters of the innate immune response were evaluated: acute phase protein synthesis of serum amyloid A and lipopolysaccharide-binding protein; total and differential circulating white blood cell counts; milk somatic cell counts; mammary vascular permeability; milk N-acetyl-beta-d-glucosaminidase (NAGase) activity; and production of the cytokines, interferon (IFN)-γ, interleukin (IL)-12, tumour growth factor(TGF)-α, and TGF-β1. The temporal response of all of these parameters following infection was similar between Holstein and Jersey cows. Further, with the exception of changes in circulating neutrophils and NAGase activity, the overall magnitude of these parameters were also comparable. Together, these data demonstrate that the innate immune response of Holstein and Jersey cows to Staph. aureus intramammary infection remains highly conserved despite previously reported differences in mastitis prevalence, as well as genotypic and phenotypic traits, that exist between the two breeds.

Keywords

Breedcytokinesdairy cowinnate immunitymastitis
Type
Research Article
Information
Journal of Dairy Research , Volume 75 , Issue 3 , August 2008 , pp. 291 - 301
Copyright
Copyright © Proprietors of Journal of Dairy Research 2008

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