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Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland

Published online by Cambridge University Press:  22 July 2005

Balázs Mayer ,
Márton Doleschall ,
Balázs Bender ,
János Bartyik ,
Zsuzsanna Bősze ,
László V Frenyó  and
Imre Kacskovics
Balázs Mayer
Affiliation:
Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent István University, PO Box 2, H-1400 Budapest, Hungary
Márton Doleschall
Affiliation:
Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent István University, PO Box 2, H-1400 Budapest, Hungary
Balázs Bender
Affiliation:
Department of Animal Biology, Agricultural Biotechnology Center, H-2100 Gödöllő, Hungary
János Bartyik
Affiliation:
Agricultural Company of Enying, H-8155 Kiscséripuszta, Hungary
Zsuzsanna Bősze
Affiliation:
Department of Animal Biology, Agricultural Biotechnology Center, H-2100 Gödöllő, Hungary
László V Frenyó
Affiliation:
Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent István University, PO Box 2, H-1400 Budapest, Hungary
Imre Kacskovics
Affiliation:
Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent István University, PO Box 2, H-1400 Budapest, Hungary
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Abstract

In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. We have recently analysed the expression of the neonatal Fc receptor (FcRn) in sheep mammary gland around parturition. Re-analysing this issue in bovine confirmed our previous data indicating that FcRn is homogeneously localized in the mammary gland acinar cells before parturition, however a remarkable difference was observed in the pattern after calving, where only the apical side of the cells was strongly stained. The presence of the FcRn in the acinar epithelial cells of the mammary gland and the obvious change in distribution before and after parturition indicate that FcRn plays an important role in the IgG transport during colostrum formation in ruminants.

Keywords

FcRnmammary glandnon-lactatingparturitionbovineIgG
Type
Research Article
Information
Journal of Dairy Research , Volume 72 , Issue S1 , August 2005 , pp. 107 - 112
Copyright
Proprietors of Journal of Dairy Research 2005

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