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Genetic ancestry modifies fatty acid concentrations in different adipose tissue depots and milk fat

Published online by Cambridge University Press:  28 February 2013

Susanne Meier ,
Gwyneth A Verkerk ,
Jane K Kay ,
Kevin A Macdonald  and
John R Roche
Susanne Meier*
Affiliation:
DairyNZ Limited, Hamilton 3240, New Zealand
Gwyneth A Verkerk
Affiliation:
DairyNZ Limited, Hamilton 3240, New Zealand
Jane K Kay
Affiliation:
DairyNZ Limited, Hamilton 3240, New Zealand
Kevin A Macdonald
Affiliation:
DairyNZ Limited, Hamilton 3240, New Zealand
John R Roche
Affiliation:
DairyNZ Limited, Hamilton 3240, New Zealand
*
*For correspondence; e-mail: susanne.meier@dairynz.co.nz
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Abstract

The objective of this study was to determine the effect of cow genetic strain on fatty acid (FA) profiles in adipose tissue and milk. Adipose samples from two subcutaneous (shoulder and tail-head) and three visceral (kidney channel, mesenteric and omental) depots were obtained post mortem from New Zealand (NZ; n = 8) and North American (NA; n = 8) Holstein–Friesian cows. At the time of slaughter cows were in similar body condition (NZ: 4·0 ± 0·03, NA: 4·0 ± 0·02; ±sd) and stage of lactation (NZ: 90 ± 11·2 d; NA: 83 ± 4·3 d; ±sd). Milk was collected during the a.m. milking prior to slaughter and milk fat was extracted. Adipose and milk fat FA were quantified using gas chromatography. NZ cows had a lower proportion of saturated FA in shoulder, tail-head and omental adipose tissue and a greater proportion of mono-unsaturated FA and an elevated Δ9-desaturase index in shoulder and tail-head adipose tissue. The proportions of individual FA differed between adipose depots, with proportions of de-novo FA greater in subcutaneous compared with visceral adipose depots. Milk from NZ cows contained greater concentrations of short chain FA (C8 : 0–12 : 0) and CLA, and less cis-9 18 : 1 than milk from NA cows. Regression analysis identified moderate associations between milk FA and shoulder adipose tissue FA for 18 : 2 (R2 = 0·24), 18 : 3 n − 3 (R2 = 0·39), and polyunsaturated fatty acids (R2 = 0·38). Results from this study support the hypothesis that genetic strain dictates FA profiles in adipose tissue and milk and may alter the metabolic status of the various adipose depots differently. The data further support the premise that genetic strain affects the metabolic status of the various adipose depots differently. Elucidating the mechanisms that regulate the different adipose depots in the NZ and NA strains will increase our understanding of tissue mobilization and replenishment.

Keywords

Genetic strainfatty acidadiposemilkdairy cow
Type
Research Article
Information
Journal of Dairy Research , Volume 80 , Issue 2 , May 2013 , pp. 197 - 204
Copyright
Copyright © Proprietors of Journal of Dairy Research 2013

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References

Bauman, DE & Currie, WB 1980 Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. Journal of Dairy Science 63 1514–1529CrossRefGoogle ScholarPubMed
Beswick, NS & Kennelly, JJ 1998 The influence of bovine growth hormone and growth hormone releasing factor on acetyl-CoA carboxylase and fatty acid synthase in primiparous Holstein cows. Comparative Biochemistry and Physiolology Part C: Pharmacology, Toxicology and Endocrinology 120 241–249Google ScholarPubMed
Butler-Hogg, BW, Wood, JD & Bines, JA 1985 Fat partitioning in British Friesian cows: the influence of physiological state on dissected body composition. Journal of Agricultural Science 104 519–528Google Scholar
Chagas, LM, Lucy, MC, Back, PJ, Blache, D, Lee, JM, Gore, PJ, Sheahan, AJ & Roche, JR 2009 Insulin resistance in divergent strains of Holstein–Friesian dairy cows offered fresh pasture and increasing amounts of concentrate in early lactation. Journal of Dairy Science 92 216–222Google Scholar
Dodson, MV, Hausman, GJ, Guan, L, Du, M, Rasmussen, TP, Poulos, SP, Mir, P, Bergen, WG, Fernyhough, ME, McFarland, DC, Rhoads, RP, Soret, B, Reecy, JM, Velleman, SG & Jiang, Z 2010 Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research. International Journal of Biological Sciences 6 691–699Google Scholar
Etherton, TD & Evock, CM 1986 Stimulation of lipogenesis in bovine adipose tissue by insulin and insulin-like growth factor. Journal of Animal Science 62 357–362Google Scholar
Etherton, TD, Evock, CM & Kensinger, RS 1987 Native and recombinant bovine growth hormone antagonize insulin action in cultured bovine adipose tissue. Endocrinology 121 699–703Google Scholar
Flowers, MT & Ntambi, JM 2008 Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Current Opinion Lipidology 19 248–256Google Scholar
Grala, TM, Lucy, MC, Phyn, CV, Sheahan, AJ, Lee, JM & Roche, JR 2011 Somatotropic axis and concentrate supplementation in grazing dairy cows of genetically diverse origin. Journal of Dairy Science 94 303–315Google Scholar
Harris, BL & Kolver, ES 2001 Review of holsteinization on intensive pastoral dairy farming in New Zealand. Journal of Dairy Science 84 Suppl.E56–E61Google Scholar
Hausman, GJ, Dodson, MV, Ajuwon, K, Azain, M, Barnes, KM, Guan, LL, Jiang, Z, Poulos, SP, Sainz, RD, Smith, S, Spurlock, M, Novakofski, J, Fernyhough, ME & Bergen, WG 2009 Board-invited review: the biology and regulation of preadipocytes and adipocytes in meat animals. Journal of Animal Science 87 1218–1246Google Scholar
Hood, RL & Allen, CE 1973 Cellularity of bovine adipose tissue. Journal of Lipid Research 14 605–610Google Scholar
Horan, B, Dillon, P, Faverdin, P, Delaby, L, Buckley, F & Rath, M 2005 The interaction of strain of Holstein-Friesian cows and pasture-based feed systems on milk yield, body weight, and body condition score. Journal of Dairy Science 88 1231–1243CrossRefGoogle ScholarPubMed
IDF 1996 Determination of Fat Content – Rose Gottlieb Gravimetric Method, International Dairy Federation Standard FIL-IDF, Report No 1D, International Dairy Federation, Brussels, BelgiumGoogle Scholar
IUPAC 1987 Preparation of fatty acid methyl ester. In Standard Methods for Analysis of Oils, Fats and Derivatives, Standard Method 2.301, 7th edition. Melbourne, Australia: International Union of Pure and Applied Chemistry, Blackwell Scientific Publications.Google Scholar
Kay, JK, Weber, WJ, Moore, CE, Bauman, DE, Hansen, LB, Chester-Jones, H, Crooker, BA & Baumgard, LH 2005 Effects of week of lactation and genetic selection for milk yield on milk fatty acid composition in Holstein cows. Journal of Dairy Science 88 3886–3893Google Scholar
Lucy, MC, Verkerk, GA, Whyte, BE, Macdonald, KA, Burton, L, Cursons, RT, Roche, JR & Holmes, CW 2009 Somatotropic axis components and nutrient partitioning in genetically diverse dairy cows managed under different feed allowances in a pasture system. Journal of Dairy Science 92 526–539CrossRefGoogle Scholar
Macdonald, KA, Verkerk, GA, Thorrold, BS, Pryce, JE, Penno, JW, McNaughton, LR, Burton, LJ, Lancaster, JA, Williamson, JH & Holmes, CW 2008 A comparison of three strains of Holstein–Friesian grazed on pasture and managed under different feed allowances. Journal of Dairy Science 91 1693–1707Google Scholar
MacGibbon, AKH 1988 Modified method of fat extraction for solid fat content determination. N.Z. Journal of Dairy Science and Technology 23 399–403Google Scholar
McCarthy, S, Berry, DP, Dillon, P, Rath, M & Horan, B 2007 Influence of Holstein-Friesian strain and feed system on body weight and body condition score lactation profiles. Journal of Dairy Science 90 1859–1869Google Scholar
McCarthy, SD, Butler, ST, Patton, J, Daly, M, Morris, DG, Kenny, DA & Waters, SM 2009 Differences in the expression of genes involved in the somatotropic axis in divergent strains of Holstein–Friesian dairy cows during early and mid lactation. Journal of Dairy Science 92 5229–5238Google Scholar
McNamara, JP & Hillers, JK 1986 Regulation of bovine adipose tissue metabolism during lactation. 1. lipid synthesis in response to increased milk production and decreased energy intake. Journal of Dairy Science 69 3032–3041Google Scholar
Meier, S, Peterson, AJ, Mitchell, MD, Littlejohn, M, Walker, C & Roche, JR 2009 Genetic strain and reproductive status affect endometrial fatty acid concentration. Journal of Dairy Science 92 3723–3730Google Scholar
Meier, S, Kolver, ES, Verkerk, GA & Roche, JR 2010 Effects of divergent Holstein-Friesian strain and diet on diurnal patterns of plasma metabolites and hormones. Journal of Dairy Research 77 432–437Google Scholar
Miyazaki, M, Dobrzyn, A, Sampath, H, Lee, S-H, Man, WC, Chu, K, Peters, JM, Gonzalez, FJ & Ntambi, JM 2004 Reduced adiposity and liver steatosis by Stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-{alpha}. Journal of Biological Chemistry 279 35017–35024CrossRefGoogle ScholarPubMed
Patton, J, Murphy, JJ, O'Mara, FP & Butler, ST 2009 Responses of North American and New Zealand strains of Holstein-Friesian dairy cattle to homeostatic challenges during early and mid-lactation. Animal 3 251–60Google Scholar
Payne, RW, Harding, SA, Murray, DA, Soutar, DM, Baird, DB, Glaser, AI, Channing, IC, Welham, SJ, Gilmour, AR, Thompson, R & Webster, R 2008 The Guide to GenStat Release 11, Part 1 & 2, Hemel Hempstead, UK: VSN InternationalGoogle Scholar
Pedron, O, Cheli, F, Senatore, E, Baroli, D & Rizzi, R 1993 Effect of body condition score at calving on performance, some blood parameters, and milk fatty acid composition in dairy cows. Journal of Dairy Science 76 2528–2535Google Scholar
Pethick, DW & Dunshea, FR 1996 The partitioning of fat in farm animals. Proceedings of the Nutrition Society of Australia 20 3–13Google Scholar
Roche, JR, Dillon, PG, Stockdale, CR, Baumgard, LH & VanBaale, MJ 2004 Relationships among international body condition scoring systems. Journal of Dairy Science 87 3076–3079CrossRefGoogle ScholarPubMed
Roche, JR, Berry, DP & Kolver, ES 2006 Holstein–Friesian strain and feed effects on milk production, body weight, and body condition score profiles in grazing dairy cows. Journal of Dairy Science 89 3532–3543Google Scholar
Schennink, A, Stoop, WM, Visker, MHPW, Heck, JML, Bovenhuis, H, Van Der Poel, JJ, Van Valenberg, HJF & Van Arendonk, JAM 2007 DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Animal Genetics 38 467–473Google Scholar
Schennink, A, Heck, J, Bovenhuis, H, Visker, M, van Valenberg, H & van Arendonk, J 2008 Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and Acyl CoA: diacylglycerol acyltransferase 1 (DGAT1). Journal of Dairy Science 91 2135–2143Google Scholar
Soyeurt, H, Gillon, A, Vanderick, S, Mayeres, P, Bertozzi, C & Gengler, N 2007 Estimation of heritability and genetic correlations for the major fatty acids in bovine milk. Journal of Dairy Science 90 4435–42CrossRefGoogle ScholarPubMed
Soyeurt, H, Dardenne, P, Dehareng, F, Bastin, C & Gengler, N 2008 Genetic parameters of saturated and monounsaturated fatty acid content and the ratio of saturated to unsaturated fatty acids in bovine milk. Journal of Dairy Science 91 3611–26Google Scholar
Stockdale, CR, Doyle, PT, Wijesudera, C & Williams, RPW 2005 Effect of body condition at calving and peri-parturient nutrition on the composition of milkfat produced by grazing dairy cows in early lactation. Australian Journal of Dairy Technology 60 244–251Google Scholar
Thomson, NA, Bryant, MO, Chand, A, MacGibbon, AKH & Chagas, LM 2002 Effect of body condition at calving on milk fat composition of Friesian heifers during the first ten weeks of lactation. Proceedings of New Zealand Society of Animal Production 62 38–41Google Scholar
Wales, WJ, Kolver, ES, Egan, AR & Roche, JR 2009 Effects of strain of Holstein-Friesian and concentrate supplementation on the fatty acid composition of milk fat of dairy cows grazing pasture in early lactation. Journal of Dairy Science 92 247–255Google Scholar
White, HM, Donkin, SS, Lucy, MC, Grala, TM & Roche, JR 2012 Short communication: genetic differences between New Zealand and North American dairy cows alter milk production and gluconeogenic enzyme expression. Journal of Dairy Science 95 455–459CrossRefGoogle ScholarPubMed
Yang, A, Larsen, T, Smith, S & Tume, R 1999 Δ9 desaturase activity in bovine subcutaneous adipose tissue of different fatty acid composition and desaturase activity in bovine subcutaneous adipose tissue of different fatty acid composition. Lipids 34 971–978Google Scholar