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Hypocholesterolemic effect of Lactobacillus gasseri SBT0270 in rats fed a cholesterol-enriched diet

Published online by Cambridge University Press:  16 April 2002

USMAN  and
AKIYOSHI HOSONO
USMAN
Affiliation:
Faculty of Agriculture, University of Riau, Pekanbaru 28293, Riau, Indonesia
AKIYOSHI HOSONO
Affiliation:
Graduate School of Agriculture, Shinshu University, Minamiminowa, Nagano-ken, 399-4598, Japan
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Abstract

The effects of administration of Lactobacillus gasseri SBT0270 on serum lipids and bile acids, faecal bile acids and microflora were estimated in hypercholesterolemic rats. An effective dose of strain SBT0270 to exert its hypocholesterolemic effect was 109 viable cells/d. The dose of 109 cells/d did not affect the faecal coliform counts, but the number of faecal lactobacilli in rats fed this dose was significantly higher than that in the control group observed at the end of feeding period. Hypocholesterolemic effect of Lb. gasseri SBT0270 was attributed to its ability to suppress the reabsorption of bile acids into the enterohepatic circulation and to enhance the excretion of acidic steroids in faeces of hypercholesterolemic rats.

Keywords

Lactobacillus gasserihypocholesterolemic effectcholesterol-enriched dietbile acidscoronary heart disease
Type
Original Article
Information
Journal of Dairy Research , Volume 68 , Issue 4 , November 2001 , pp. 617 - 624
Copyright
Proprietors of Journal of Dairy Research 2001

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