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The interaction of monensin and flaxseed hulls on ruminal and milk concentration of the mammalian lignan enterolactone in late-lactating dairy cows

Published online by Cambridge University Press:  13 October 2009

Hélène V Petit ,
Cristiano Côrtes ,
Daniele da Silva ,
Ricardo Kazama ,
Nathalie Gagnon ,
Chaouki Benchaar ,
Geraldo T dos Santos  and
Lúcia M Zeoula
Hélène V Petit*
Affiliation:
Dairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, P. O. Box 90, Stn Lennoxville, Sherbrooke, QC J1M 1Z3, Canada
Cristiano Côrtes
Affiliation:
Dairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, P. O. Box 90, Stn Lennoxville, Sherbrooke, QC J1M 1Z3, Canada
Daniele da Silva
Affiliation:
Departamento de Zootecnia, Universidade Estadual de Maringa, Maringa, PR, Brazil
Ricardo Kazama
Affiliation:
Departamento de Zootecnia, Universidade Estadual de Maringa, Maringa, PR, Brazil
Nathalie Gagnon
Affiliation:
Dairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, P. O. Box 90, Stn Lennoxville, Sherbrooke, QC J1M 1Z3, Canada
Chaouki Benchaar
Affiliation:
Dairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, P. O. Box 90, Stn Lennoxville, Sherbrooke, QC J1M 1Z3, Canada
Geraldo T dos Santos
Affiliation:
Departamento de Zootecnia, Universidade Estadual de Maringa, Maringa, PR, Brazil
Lúcia M Zeoula
Affiliation:
Departamento de Zootecnia, Universidade Estadual de Maringa, Maringa, PR, Brazil
*
*For correspondence; e-mail: helene.petit@agr.gc.ca
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Abstract

Four ruminally fistulated multiparous Holstein cows were assigned to a 4×4 Latin square design with a 2×2 factorial arrangement of treatments to study the effects of dietary supplementation of monensin and flaxseed hulls on ruminal and milk concentration of the mammalian lignan enterolactone (EL) and ruminal and faecal activity of β-glucuronidase. The hypothesis was that monensin supplementation has no effect on the incorporation of EL into milk when cows are fed flaxseed hulls. Treatments were: 1) control, neither flaxseed hulls nor monensin (CO); 2) diet containing (dry matter basis) 20% flaxseed hulls (FH); 3) diet with monensin (16 mg/kg of dry matter; MO); 4) diet containing 20% (dry matter basis) flaxseed hulls and 16 mg/kg monensin (HM). Intake of dry matter was higher for CO and MO than for FH and HM and monensin had no effect. Milk production decreased in cows fed flaxseed hulls while monensin had no effect. Production of 4% fat-corrected milk and concentrations of milk fat, lactose, urea N, and total solids were similar among treatments. Although there was a decrease in ruminal activity of β-glucuronidase when feeding flaxseed hulls, the metabolism of plant into mammalian lignans may be increased as shown by enhanced concentration of EL in the rumen and milk. Supplementation with flaxseed hulls then may contribute to favourably change milk composition for better human health by enhancing mammalian lignan EL concentration.

Keywords

Dairy cattleflaxseedlignansmilk production
Type
Research Article
Information
Journal of Dairy Research , Volume 76 , Issue 4 , November 2009 , pp. 475 - 482
Copyright
Copyright © Proprietors of Journal of Dairy Research 2009

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References

Adlercreutz, H & Mazur, W 1997 Phyto-oestrogens and western diseases. Annals of Medicine 29 95–120CrossRefGoogle ScholarPubMed
Association of Official Analytical Chemists 1990 Official methods of analysis 15th edAOAC Washington, DC, USAGoogle Scholar
Bannwart, C, Adlercreutz, H, Wähälä, K, Kotiaho, T, Hesso, A, Brunow, G & Hase, T 1988 Identification of the phyto-oestrogen 3',7-dihydroxyisoflavan, an isomer of equol, in human urine and cow's milk. Biomedical and Environmental Mass Spectrometry 17 1–6CrossRefGoogle ScholarPubMed
Beaud, D, Tailliez, P & Anba-Mondoloni, J 2005 Genetic characterization of the beta-glucuronidase enzyme from a human intestinal bacterium, Ruminococcus gnavus. Microbiology 151 2323–2330Google ScholarPubMed
Bell, JA, Griinari, JM & Kennelly, JJ 2006 Effect of safflower oil, flaxseed oil, monensin, and vitamin E on concentration of conjugated linoleic acid in bovine milk fat. Journal of Dairy Science 89 733–748CrossRefGoogle ScholarPubMed
Benson, JA, Reynolds, CK, Humphries, DJ, Rutter, SM & Beever, DE 2001 Effects of abomasal infusion of long-chain fatty acids on intake, feeding behavior and milk production in dairy cows. Journal of Dairy Science 84 1182–1191CrossRefGoogle ScholarPubMed
Benzie, IFF & Strain, JJ 1999 Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. In Methods in Enzymology, pp. 15–27 (Ed. Packer, L). Orlando, FL, USA: Academic Press, Vol. 299.Google Scholar
Borriello, SP, Setchell, KDR, Axelson, M & Lawson, AM 1985 Production and metabolism of lignans by the human faecal flora. Journal of Applied Bacteriology 58 37–43CrossRefGoogle ScholarPubMed
Broderick, GA 2004 Effect of low level monensin supplementation on the production of dairy cows fed alfalfa silage. Journal of Dairy Science 87 359–68Google Scholar
CCAC (Canadian Council on Animal Care) 1993 Guide to the Care and Use of Experimental Animals Vol. 1 (Eds Olfert, ED, Cross, BM and McWilliam, AA). CCAC, Ottawa, ON, Canada.Google Scholar
Côrtes, C, Gagnon, N, Benchaar, C, da Silva, D, Santos, GTD & Petit, HV 2008 In vitro metabolism of flax lignans by ruminal and fecal microbiota of dairy cows. Journal of Applied Microbiology 105 1585–1594Google Scholar
da Silva, DC, Santos, GTD, Branco, AF, Damasceno, JC, Kazama, R, Matsushita, M, Horst, JA, dos Santos, WBR & Petit, HV 2007 Production performance and milk composition of dairy cows fed whole or ground flaxseed with or without monensin. Journal of Dairy Science 90 2928–2936CrossRefGoogle ScholarPubMed
Dhiman, TR, Satter, LD, Pariza, MW, Galli, MP, Albridht, K & Tolosa, MX 2000 Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. Journal of Dairy Science 83 1016–1027CrossRefGoogle Scholar
Dickinson, JM, Smith, GR, Rander, RD & Pemberton, IJ 1988 In vitro metabolism of formononetin and biochanin in bovine rumen fluid. Journal of Animal Science 66 1969–1973CrossRefGoogle ScholarPubMed
Duffield, TF, LeBlanc, S, Bagg, R, Leslie, K, Ten Hag, J & Dick, P 2003 Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. Journal of Dairy Science 86 1171–1176Google Scholar
Duffield, TF, Rabiee, AR & Lean, IJ 2008 A meta-analysis of the impact of monensin in lactating dairy cattle. Part 2. Production effects. Journal of Dairy Science 91 1347–1360Google Scholar
Frank, AA & Custer, LJ 1996 Diadzein and genistein concentration sin human milk after soy consumption. Clinical Chemistry 42 955–964CrossRefGoogle Scholar
Gagnon, N, Côrtes, C, da Silva, D, Kazama, R, dos Santos, G, Zeoula, L, Benchaar, C & Petit, HV 2009 Ruminal metabolism of flaxseed (Linum usitatissimum) lignans to the mammalian lignan enterolactone and its concentration in ruminal fluid, plasma, urine, and milk of dairy cows. British Journal of Nutrition doi:10.1017/S0007114509344104CrossRefGoogle Scholar
Heinonen, S, Nurmi, T, Kiukkonen, K, Poutanen, K, Wähälä, K, Deyama, T, Nishibe, S & Adlercreutz, H 2001 In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterediol. Journal of Agriculture and Food Chemistry 49 3178–3186CrossRefGoogle Scholar
Henderson, C 1973 The effects of fatty acids on pure cultures of rumen bacteria. Journal of Agricultural Science Cambridge 81 107–112Google Scholar
Ipharraguerre, IR & Clark, JH 2003 Usefulness of ionophores for lactating dairy cows: A review. Animal Feed Science and Technology 106 39–57Google Scholar
Jenab, M & Thompson, LU 1996 The influence of flaxseed and lignans on colon carcinogenesis and β-glucuronidase activity. Carcinogenesis 17 1343–1348CrossRefGoogle ScholarPubMed
Kitts, DD, Yuan, YV, Wijewickreme, AN & Thompson, LU 1999 Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Molecular and Cellular Biochemistry 202 91–100Google Scholar
Knudsen, KEB, Serena, LU, Kjær, AKB, Tetens, I, Heinonen, S, Nurmi, T & Adlercreutz, H 2003 Rye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and feces. Journal of Nutrition 5 1368–1375Google Scholar
Maia, MRG, Chaudhary, LC, Figueres, L & Wallace, RJ 2007 Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen. Antonie Van Leeuwenhoek 91 303–314Google Scholar
Muir, AD & Westcott, ND 2000 Quantification of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal. Journal of Agricultural Food Chemistry 48 4048–4052CrossRefGoogle ScholarPubMed
Murkies, AL, Wilcox, G & Davis, SR 1998 Phytoestrogens. Journal of Clinical Endocrinology and Metabolism 83 297–303Google Scholar
National Research Council 2001 Nutrient Requirements of Dairy Cattle. 7th rev. ed.Nat. Acad. Press, Washington, DC, USAGoogle Scholar
Osborne, JK, Mutsvangwa, T, Alzahal, O, Duffield, TF, Bagg, R, Dick, P, Vessie, G & McBride, BW 2004 Effects of monensin on ruminal forage degradability and total tract diet digestibility in lactating dairy cows during grain-induced subacute ruminal acidosis. Journal of Dairy Science 87 1840–1847CrossRefGoogle ScholarPubMed
Petit, HV, Dewhurst, RJ, Scollan, ND, Proulx, JG, Khalid, M, Haresign, W, Twagiramungu, H & Mann, GE 2002 Milk production and composition, ovarian function, and prostaglandin secretion of dairy cows fed omega-3 fats. Journal of Dairy Science 85 889–899Google Scholar
Petit, HV & Gagnon, N 2009 Milk concentrations of the mammalian lignans enterolactone and enterodiol, milk production, and whole tract digestibility of dairy cows fed diets containing different concentrations of flaxseed meal. Animal Feed Science and Technology 152 103–111CrossRefGoogle Scholar
Phipps, RH, Wilkinson, JI, Jonker, LJ, Tarrant, M, Jones, AK & Hodge, A 2000 Effect of monensin on milk production of Holstein-Friesian dairy cows. Journal of Dairy Science 83 2789–2794Google Scholar
Raffaelli, B, Hoikkala, A, Leppälä, E & Wähälä, K 2002 Enterolignans. Journal of Chromatography B 777 29–43CrossRefGoogle ScholarPubMed
Ramanzin, M, Bailoni, L, Schiavon, S & Bittante, G 1997 Effect of monensin on milk production and efficiency of dairy cows fed two diets differing in forage to concentrate ratios. Journal of Dairy Science 80 1136–1142Google Scholar
Rowan, AM, Haggarty, NW & Ram, S 2005 Milk bioactives: discovery and proof of concept. Australian Journal of Dairy Technolology 60 114–118Google Scholar
SAS. Statistical Analysis System, Release 8.02. 2000. Cary, NC., SAS Inst. Inc.Google Scholar
Sauer, FD, Fellner, V, Kinsman, R, Kramer, JKG, Jackson, HA, Lee, AJ & Chen, S 1998 Methane output and lactation response in Holstein cattle with monensin or unsaturated fat added to the diet. Journal of Animal Science 76 906–914CrossRefGoogle ScholarPubMed
Setchell, KDR, Lawson, AM, Mitchell, FL, Adlercreutz, H, Kirk, DN & Axelson, M 1980 Lignans in man and in animal species. Nature 287 740–742Google Scholar
Smet, K, Raes, K, De Block, J, Herman, L, Dewettinck, K & Coudijzer, K 2008 A change in antioxidative capacity as a measure of onset to oxidation in pasteurized milk. International Dairy Journal 18 520–530Google Scholar
Steinshamn, H, Purup, S, Thuen, E & Hansen-Møller, J 2008 Effects of clover-grass silages and concentrate supplementation on the content of phytoestrogens in dairy cow milk. J Dairy Sci 91 2715–2725CrossRefGoogle ScholarPubMed
Tyrrell, HF & Reid, JT 1965 Prediction of the energy value of cow's milk. Journal of Dairy Science 48 1215–1223Google Scholar
Vanharanta, M, Voutilainen, S, Lakka, TA, Van der Lee, M, Adlercreutz, H & Salonen, JT 1999 Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet 354 2112–2115Google Scholar
Van Soest, PJ, Robertson, JB & Lewis, BA 1991 Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science 74 3583–3597Google Scholar