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Retinol binding protein 4 in dairy cows: its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period

Published online by Cambridge University Press:  29 September 2009

Mabrouk A Abd Eldaim ,
Akihiro Kamikawa ,
Mohamed M Soliman ,
Mohamed M Ahmed ,
Yuko Okamatsu-Ogura ,
Akira Terao ,
Toru Miyamoto  and
Kazuhiro Kimura
Mabrouk A Abd Eldaim
Affiliation:
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
Akihiro Kamikawa
Affiliation:
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
Mohamed M Soliman
Affiliation:
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
Mohamed M Ahmed
Affiliation:
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
Yuko Okamatsu-Ogura
Affiliation:
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
Akira Terao
Affiliation:
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
Toru Miyamoto
Affiliation:
Production Disease Team, National Institute of Animal Health, Japan
Kazuhiro Kimura*
Affiliation:
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
*
*For correspondence; e-mail: k-kimura@vetmed.hokudai.ac.jp
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Abstract

Retinol-binding protein 4 (RBP4) is a plasma protein involved in retinol transportation, and recent evidence in rodents suggests that RBP4 is also a metabolic regulator that modifies insulin sensitivity. To assess how RBP4 levels are regulated in ruminants, we determined the RBP4 concentrations in bovine plasma and milk using Western blot analysis. Plasma RBP4 levels in non-pregnant non-lactating (control) cows were around 45 μg/ml, which were sustained during 60-h fasting, but decreased significantly 4 h after lipopolysaccharide (LPS) administration. Basal plasma retinol concentration was around 30 μg/dl, but this decreased to approximately one-third and one-half of these values during fasting and 8 h after LPS challenge, respectively. Plasma RBP4 and retinol levels in cows 3–6 d before parturition were comparable to those of the controls. However, on the day of parturition both were significantly decreased and had returned to basal levels by two weeks after calving. Interestingly, RBP4 was clearly detected in colostrum (16·4±5·6 μg/ml) but was only faintly detected in milk from cows at 7 d and 15 d after calving. Retinol concentrations in colostrum were almost 10-fold higher than those in plasma, while those in milk were comparable to those in plasma. These results suggest that RBP4 and retinol levels are independently regulated under physiological and pathophysiological conditions and that RBP4, like retinol, is transferred from maternal stores to calves through colostrum.

Keywords

ColostrumcattleRBP4retinolvitamin A
Type
Research Article
Information
Journal of Dairy Research , Volume 77 , Issue 1 , February 2010 , pp. 27 - 32
Copyright
Copyright © Proprietors of Journal of Dairy Research 2009

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References

Aeberli, I, Biebinger, R, Lehmann, R, l'Allemand, D, Spinas, GA & Zimmermann, MB 2007 Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. Journal of Clinical Endocrinology and Metabolism 92 4359–4365CrossRefGoogle ScholarPubMed
Baird, GD, Heitzman, RJ & Hibbitt, KG 1972 Effects of starvation on intermediary metabolism in the lactating cow. Biochemical Journal 128 1311–1318CrossRefGoogle ScholarPubMed
Barrington, GM, McFadden, TB, Huyler, MT & Besser, TE 2001 Regulation of colostrogenesis in cattle. Livestock Production Science 70 95–104CrossRefGoogle Scholar
Blomhoff, R & Blomhoff, HK 2006 Overview of retinoid metabolism and function. Journal of Neurobiology 66 606–630CrossRefGoogle ScholarPubMed
Blum, JW, Hadorn, U, Sallmann, H-P & Schuep, W 1997 Delaying colostrum intake by one day impairs the plasma lipid, essential fatty acid, carotene, retinol and α-tocopherol status in neonatal calves. Journal of Nutrition 127 2024–2029Google Scholar
Blum, JW 2006 Nutritional physiology of neonatal calves. Journal of Animal Physiology and Animal Nutrition 90 1–11CrossRefGoogle ScholarPubMed
Carroll, JA & Forsberg, NE 2007 Influence of stress and nutrition on cattle immunity. Veterinary Clinics of North America—Food Animal Practice 23 105–149CrossRefGoogle ScholarPubMed
Craft, NE 2001 Innovative approaches to vitamin A assessment. Journal of Nutrition 131 1626S–1630SCrossRefGoogle ScholarPubMed
Debier, C, Potter, J, Goffe, C & Larondell, Y 2005 Present knowledge and unexpected behaviors of vitamin A and E in colostrum and milk. Livestock Production Science 98 135–147CrossRefGoogle Scholar
Goff, JP & Stabel, JR 1990 Decreased plasma retinol, α-tocopherol, and zinc concentration during the periparturient period: Effect of milk fever. Journal of Dairy Science 73 3195–3199CrossRefGoogle ScholarPubMed
Goff, JP, Kimura, K & Horst, RL 2002 Effect of mastectomy on milk fever, energy, and vitamins A, E, and β-carotene status at parturition. Journal of Dairy Science 85 1427–1436Google Scholar
Gorocica-Buenfil, MA, Fluharty, FL & Loerch, SC 2008 Effect of vitamin A restriction on carcass characteristics and immune status of beef steers. Journal of Animal Science 86 1609–1616CrossRefGoogle ScholarPubMed
Graham, E, Yang, Q, Blüher, M, Hammarstedt, A, Ciaraldi, TP, Henry, RR, Wason, CJ, Oberbach, A, Jansson, P-A, Smith, U & Kahn, BB 2006 Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. New England Journal of Medicine 354 2552–2563CrossRefGoogle ScholarPubMed
Johnston, LA & Chew, BP 1984 Peripartum changes of plasma and milk vitamin A and β-carotene among dairy cows with or without mastitis. Journal of Dairy Science 67 1832–1840CrossRefGoogle ScholarPubMed
Kanda, Y, Yamamoto, N & Yoshino, Y 1990 Utilization of vitamin A in rats with inflammation. Biochimica et Biophysica Acta 1034 337–341CrossRefGoogle ScholarPubMed
Kawaguchi, R, Yu, J, Honda, J, Hu, J, Whitelegge, J, Ping, P, Wiita, P, Bok, D & Sun, H 2007 A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 315 820–825CrossRefGoogle ScholarPubMed
Kumagai, H, Chaipan, Y & Mitani, K 2000 Effect of supplementary vitamin A on plasma retinol concentrations, fertility and milk yield of dairy cows. Animal Science Journal 71 143–149Google Scholar
Kumagai, H, Chaipan, Y & Mitani, K 2001 Effects of periparturient vitamin A supplementation on vitamin A concentrations in colostrum and milk from dairy cows, and plasma retinol concentrations, feed intake and growth of their calves. Animal Science Journal 72 126–133Google Scholar
Lindberg, L-A, Sinkkonen, H, Poso, AR, Tesfa, AT & Schroder, J 1999 Production of monoclonal antibodies and enzyme immunoassay to bovine retinol-binding protein and determination of retinol-binding protein serum levels and retinol concentrations in serum and liver in dairy cows before and after parturition. Research in Veterinary Science 66 259–263CrossRefGoogle ScholarPubMed
Miyamoto, T, Katoh, N, Motoi, Y, Ohashi, T, Nagasawa, S & Shimbayashi, K 1989 Retinol transport system in cattle and purification of retinol-binding protein from bovine serum. Japanese Journal of Veterinary Science 51 408–415Google ScholarPubMed
Nonnecke, BJ, Roberts, MP, Godkin, JD, Horst, RL, Hammell, DC & Franklin, ST 2001 Influence of supplemental, dietary vitamin A on retinol-binding protein concentrations in the plasma of preruminant calves. Journal of Dairy Science 84 641–648Google Scholar
Noy, N 2000 Retinoid-binding proteins: mediators of retinoid action. Biochemical Journal 348 481–495CrossRefGoogle ScholarPubMed
Perez, MD & Calvo, M 1995 Interaction of β-lactoglobulin with retinol and fatty acids and its role as a possible biological function for this protein: a review. Journal of Dairy Science 78 978–988CrossRefGoogle ScholarPubMed
Puvogel, G, Baumrucker, C & Blum, JW 2008 Plasma vitamin A status in calves fed colostrum from cows that were fed vitamin A during late pregnancy. Journal of Animal Physiology and Animal Nutrition 92 614–620CrossRefGoogle ScholarPubMed
Quadro, L, Gamble, MV, Vogel, S, Lima, AAM, Piantedosi, V, Moore, SR, Colantuoni, V, Gottesman, ME, Guerrant, RL & Blaner, WS 2000 Retinol and retinol-binding protein: gut integrity and circulating immunoglobulins. Journal of Infectious Diseases 182 S97–S102CrossRefGoogle ScholarPubMed
Rezamand, P, Hoagland, TA, Moyes, KM, Silbart, LK & Andrew, SM 2007 Energy status, lipid-soluble vitamins, and acute phase proteins in periparturient Holstein and Jersey dairy cows with or without subclinical mastitis. Journal of Dairy Science 90 5097–5107CrossRefGoogle ScholarPubMed
Rosales, FJ, Ritter, SJ, Zolfaghari, R, Smith, JE & Ross, AC 1996 Effects of acute inflammation on plasma retinol, retinol-binding protein, and its mRNA in the liver and kidneys of vitamin A-sufficient rats. Journal of Lipid Research 37 962–971CrossRefGoogle ScholarPubMed
Said, HM, Ong, DE & Shingleton, JL 1989 Intestinal uptake of retinol: enhancement by bovine milk β-lactoglobulin. American Journal of Clinical Nutrition 49 690–694CrossRefGoogle ScholarPubMed
Shenai, JP, Rush, MG, Stahlman, MT & Chytil, F 1990 Plasma retinol-binding protein response to vitamin A administration in infants susceptible to bronchopulmonary dysplasia. Journal of Pediatrics 116 607–614CrossRefGoogle ScholarPubMed
Stephensen, CB 2001 Vitamin A, infection, and immune function. Annual Review of Nutrition 21 167–192CrossRefGoogle ScholarPubMed
Suzuki, J & Katoh, N 1990 A simple and cheap method for measuring serum vitamin A in cattle using only a spectrophotometer. Japanese Journal of Veterinary Science 52 1281–1283Google Scholar
Taylor, VJ, Cheng, Z, Pushpakumara, PGA, Beever, DE & Wathes, DC 2004 Relationships between the plasma concentrations of insulin-like growth factor-I in dairy cows and their fertility and milk yield. Veterinary Record 155 583–588CrossRefGoogle ScholarPubMed
Thurnham, DI, Norhrop-Clewes, CA, McCullough, FSW, Das, BS & Lunn, PG 2000 Innate immunity, gut integrity, and vitamin A in Gambian and Indian infants. Journal of Infectious Diseases 182 S23–S28Google Scholar
Van de Perre, P 2003 Transfer of antibody via mother's milk. Vaccine 21 3374–3376CrossRefGoogle ScholarPubMed
Van Merris, V, Meyer, E, Duchateau, L, Blum, J & Burvenich, C 2004 All-trans retinoic acid is increased in the acute phase-related hyporetinemia during Escherichia coli mastitis. Journal of Dairy Science 87 980–987CrossRefGoogle ScholarPubMed
Yang, Q, Graham, TE, Mody, N, Preitner, F, Peroni, OD, Zabolotny, JM, Kotani, K, Quadro, L & Kahn, BB 2005 Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 356–362CrossRefGoogle ScholarPubMed