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Rumen-protected methionine supplementation during the peripartal period alters the expression of galectin genes associated with inflammation in peripheral neutrophils and secretion in plasma of Holstein cows

Published online by Cambridge University Press:  15 November 2019

Emmanuel K. Asiamah ,
Mario Vailati-Riboni ,
Zheng Zhou ,
Tianle Xu ,
Juan J. Loor ,
Keith Schimmel  and
Mulumebet Worku
Emmanuel K. Asiamah
Affiliation:
Department of Agriculture-Animal Science, University of Arkansas-Pine Bluff, Pine Bluff, AR, USA
Mario Vailati-Riboni
Affiliation:
Department of Animal Sciences, University of Illinois, Urbana, USA
Zheng Zhou
Affiliation:
Department of Animal Science, Michigan State University, MI, USA
Tianle Xu
Affiliation:
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
Juan J. Loor
Affiliation:
Department of Animal Sciences, University of Illinois, Urbana, USA
Keith Schimmel
Affiliation:
Department of Agriculture-Animal Science, University of Arkansas-Pine Bluff, Pine Bluff, AR, USA
Mulumebet Worku*
Affiliation:
Department of Animal Sciences, North Carolina A&T State University, Greensboro, NC, USA
*
Author for correspondence: Mulumebet Worku, Email: worku@ncat.edu
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Abstract

The work described in this research communication aimed to investigate whether rumen-protected methionine (Met) supplementation during the periparturient period would affect the expression of galectins in blood-derived neutrophils, and secretion of galectins, IL (interleukin)-1β, IL-6, myeloperoxidase (MPO), and glucose in plasma. Because supplementation of rumen-protected Met would alleviate inflammation and oxidative stress during the peripartal period, we hypothesized that enhancing Met supply would benefit the innate immune response at least in part by altering the expression of galectin genes associated with neutrophil activity and inflammation. Galectins (Gal) have an immuno-modulating effect acting like cell-surface receptors whose activation often results in signaling cascades stimulating cells such as neutrophils. This study revealed an association between Met supplementation and galectin expression and secretion. This implies that galectin expression and secretion can be modulated by Met supplementation. Further studies are needed to evaluate the regulation of galectin gene expression for therapeutic and dietary intervention in the peripartal cow.

Keywords

Galectinsmethionineneutrophilsperiparturient cow
Type
Research Article
Information
Journal of Dairy Research , Volume 86 , Issue 4 , November 2019 , pp. 394 - 398
Copyright
Copyright © Hannah Dairy Research Foundation 2019

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