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Female ponderal index at birth and idiopathic infertility

Part of: DOHaD on International Women's Day 2020

Published online by Cambridge University Press:  16 July 2019

Charlotte Dupont ,
Audrey Hulot ,
Florence Jaffrezic ,
Céline Faure ,
Sébastien Czernichow ,
Nathalie di Clemente ,
Chrystele Racine ,
Pascale Chavatte-Palmer ,
Rachel Lévy  and
Alifert group
Charlotte Dupont*
Affiliation:
Sorbonne Université, Saint Antoine Research center, INSERM équipe Lipodystrophies génétiques et acquises. Service de biologie de la reproduction-CECOS, AP-HP, Hôpital Tenon, F-75020 Paris, France
Audrey Hulot
Affiliation:
UMR GABI, AgroParisTech, INRA, Université Paris-Saclay, 78350Jouy-en-Josas, France UMR Mia-Paris, AgroParisTech, INRA, Université Paris-Saclay, 75005Paris, France Inserm U1173, Simone Veil School of Health Sciences, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
Florence Jaffrezic
Affiliation:
UMR GABI, AgroParisTech, INRA, Université Paris-Saclay, 78350Jouy-en-Josas, France
Céline Faure
Affiliation:
Service de biologie de la reproduction-CECOS, APHP, Hôpital Tenon, Paris, France
Sébastien Czernichow
Affiliation:
Service de nutrition (Centre Spécialisé Obésité), Hôpital Européen Georges-Pompidou, APHP Paris, France Université Paris Descartes, ParisFrance
Nathalie di Clemente
Affiliation:
Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université-INSERM, 75012Paris, France Institut Hospitalo-Universitaire ICAN, 75013Paris, France
Chrystele Racine
Affiliation:
Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université-INSERM, 75012Paris, France Institut Hospitalo-Universitaire ICAN, 75013Paris, France Université de Paris, Saint Antoine Research center, INSERM équipe Lipodystrophies génétiques et acquises, F-75012 Paris, France
Pascale Chavatte-Palmer
Affiliation:
UMR BDR, INRA, ENVA, Université Paris Saclay, 78350, Jouy en Josas, France
Rachel Lévy
Affiliation:
Sorbonne Université, Saint Antoine Research center, INSERM équipe Lipodystrophies génétiques et acquises. Service de biologie de la reproduction-CECOS, AP-HP, Hôpital Tenon, F-75020 Paris, France
*
Address for correspondence: Charlotte Dupont, Saint Antoine Research center, INSERM équipe Lipodystrophies génétiques et acquises, Sorbonne Université and Service de biologie de la reproduction-CECOS, AP-HP, Hôpital Tenon, F-75020 Paris, France. Email: charlotte.dupont@aphp.fr
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Abstract

Epidemiological studies have demonstrated an increased risk of developing non-transmittable diseases in adults subjected to adverse early developmental conditions. Metabolic and cardiovascular diseases have been the focus of most studies. Nevertheless, data from animal models also suggest early programming of fertility. In humans, it is difficult to assess the impact of the in utero environment retrospectively. Birthweight is commonly used as an indirect indicator of intrauterine development. This research is part of the ALIFERT study. We investigated a potential link between ponderal index at birth and female fertility in adulthood. Data from 51 infertile and 74 fertile women were analysed. BW was on average higher in infertile women, whereas birth length did not differ between the two groups; thus, resulting in a significantly higher ponderal index at birth in infertile women. Ponderal index at birth has been identified as a risk factor for infertility. These results suggest the importance of the intra-uterine environment, not only for long-term metabolic health but also for fertility.

Keywords

ponderal indexbirthweightfemale fertilityfemale infertility
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 2 , April 2020 , pp. 154 - 158
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019

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Footnotes

Alifert Collaborative Group: Isabelle Aknin: Unité fonctionnelle de biologie de la reproduction, histologie – embryologie – cytogénétique, hôpital Nord, Saint-Étienne, France ; Isabelle Cedrin-Durnerin: Service de Médecine de la Reproduction, Hôpital Jean Verdier, APHP, Bondy, France ; Steven Cens, Centre d’AMP de PAU, Polyclinique de Navarre, Pau, France; Serge Hercberg: EREN, INSERM U557; INRA; CNAM; Université Paris 13, CRNH IdF, 93017 Bobigny, France; Khaled Pocate: Service d’Histologie-Embryologie-Biologie de la Reproduction, Hôpital Cochin APHP, Paris, France; Nathalie Sermondade: Service de biologie de la reproduction-CECOS, Hôpital Tenon, APHP, Paris, France ; Claude Uthurriague, Centre d’AMP de PAU, Polyclinique de Navarre, Pau ; Jean-Philippe Wolf: Service d’Histologie-Embryologie-Biologie de la Reproduction, Hôpital Cochin, APHP, Paris, France

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