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First trimester maternal exposures to endocrine disrupting chemicals and metals and fetal size in the Michigan Mother–Infant Pairs study

Published online by Cambridge University Press:  30 January 2019

Jaclyn M. Goodrich Open the ORCID record for Jaclyn M. Goodrich [Opens in a new window] ,
Mary E. Ingle ,
Steven E. Domino ,
Marjorie C. Treadwell ,
Dana C. Dolinoy ,
Charles Burant ,
John D. Meeker  and
Vasantha Padmanabhan
Jaclyn M. Goodrich*
Affiliation:
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
Mary E. Ingle
Affiliation:
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
Steven E. Domino
Affiliation:
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA
Marjorie C. Treadwell
Affiliation:
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA
Dana C. Dolinoy
Affiliation:
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
Charles Burant
Affiliation:
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
John D. Meeker
Affiliation:
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
Vasantha Padmanabhan*
Affiliation:
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
*
Address for correspondence: J. M. Goodrich, University of Michigan School of Public Health, Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, MI 48109, USA. E-mail: gaydojac@umich.edu V. Padamanabhan, University of Michigan, Pediatrics, 1137 Catherine St., Ann Arbor, MI, 48109, USA. Email: vasantha@umich.edu
Address for correspondence: J. M. Goodrich, University of Michigan School of Public Health, Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, MI 48109, USA. E-mail: gaydojac@umich.edu V. Padamanabhan, University of Michigan, Pediatrics, 1137 Catherine St., Ann Arbor, MI, 48109, USA. Email: vasantha@umich.edu
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Abstract

Exposures to endocrine disrupting chemicals and metals are near ubiquitous worldwide, and their potential impact on children is a major public health concern. This pilot study was designed to characterize exposures to phthalates, phenols and metals among pregnant women in the first trimester, and to examine associations with fetal biometrics and birth weight. A total of 41 chemicals and elements were analyzed in urine from 56 mothers with full-term newborns from the Michigan Mother–Infant Pairs study. Bivariate analyses identified predictors of exposure biomarkers. Associations between birth weight, Fenton z-scores and second trimester fetal biometrics with toxicants were examined via multivariable linear regression. An average of 30 toxicants were detected in maternal urine. Fast food consumption was associated with several phthalate metabolites, phenols and metals, and canned food consumption with bisphenol F (P <0.05). Mono (3-carboxypropyl) phthalate was significantly associated with higher birth weight and Fenton z-score while the opposite was observed for bisphenol S. Estimated femur length from ultrasonography was significantly inversely associated with arsenic, barium and lead. While limited by sample size, this study is one of the first to evaluate birth outcomes with respect to emerging endocrine disrupting chemicals and to examine associations between toxicants and fetal biometrics. Exposure assessment was provided by the National Institute of Environmental Health Sciences’ Children’s Health Exposure Analysis Resource (NIEHS CHEAR), a resource available to children’s studies with the goal of combining data across cohorts in an effort to characterize the impact of toxicants on child health from birth and beyond.

Keywords

birth outcomesmetalsphenolsphthalatesprenatal exposures
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 4 , August 2019 , pp. 447 - 458
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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Footnotes

a

These authors contributed equally to this work.

b

These authors also contributed equally to this work.

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