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Newborn electroencephalographic correlates of maternal prenatal depressive symptoms

Part of: French DOHaD

Published online by Cambridge University Press:  06 March 2018

H. C. Gustafsson Open the ORCID record for H. C. Gustafsson [Opens in a new window] ,
P. G. Grieve ,
E. A. Werner ,
P. Desai  and
C. Monk
H. C. Gustafsson*
Affiliation:
Department of Psychiatry, Oregon Health and Science University, Portland, OR, USA
P. G. Grieve
Affiliation:
Department of Pediatrics, Columbia University Medical Center, New York, NY, USA Department of Biomedical Engineering, Columbia University, New York, NY, USA
E. A. Werner
Affiliation:
Departments of Psychiatry and Obstetrics & Gynecology, Columbia University Medical Center, New York, NY, USA
P. Desai
Affiliation:
Departments of Psychiatry and Obstetrics & Gynecology, Columbia University Medical Center, New York, NY, USA
C. Monk
Affiliation:
Departments of Psychiatry and Obstetrics & Gynecology, Columbia University Medical Center, New York, NY, USA New York State Psychiatric Institute, New York, NY, USA
*
*Address for correspondence: H. C. Gustafsson, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Multnomah Pavilion, Suite 1505, Portland, OR 97239, USA. E-mail: gustafha@ohsu.edu
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Abstract

Maternal perinatal depression exerts pervasive effects on the developing brain, as evidenced by electroencephalographic (EEG) patterns that differ between children of women who do and do not meet DSM or ICD diagnostic criteria. However, little research has examined if the same EEG pattern of right-frontal alpha asymmetry exists in newborns and thus originates in utero independent of postnatal influences, and if depressive symptoms are associated with this neural signature. Utilizing 125-lead EEG (n=18), this study considered clinician-rated maternal prenatal depressive symptoms in relation to newborn EEG. Maternal depressive symptomatology was associated with greater relative right-frontal alpha asymmetry during quiet sleep. These results suggest that even subclinical levels of maternal depression may influence infant brain development, and further support the role of the prenatal environment in shaping children’s future neurobehavioral trajectories.

Keywords

electroencephalographynewbornpregnancyprenatal depression
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 4: Themed Issue: French DOHaD , August 2018 , pp. 381 - 385
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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