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Renal developmental disturbances and their long-term consequences in female pups from vitamin D-deficient mothers: involved mechanisms

Published online by Cambridge University Press:  06 February 2019

L. F. Almeida ,
H. D. C. Francescato ,
R. S. Silva ,
C. G. A. Silva ,
J. Antunes-Rodrigues ,
F. J. A. de Paula  and
T. M. Coimbra
L. F. Almeida
Affiliation:
Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
H. D. C. Francescato
Affiliation:
Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
R. S. Silva
Affiliation:
Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
C. G. A. Silva
Affiliation:
Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
J. Antunes-Rodrigues
Affiliation:
Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
F. J. A. de Paula
Affiliation:
Internal Medicine of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
T. M. Coimbra*
Affiliation:
Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
*
Address for correspondence: T. M. Coimbra, Department of Physiology, Ribeirão Preto Medical School/USP, Avenida dos Bandeirantes, 3900, Ribeirão Preto 14049-900, SP, Brazil. E-mail: tmcoimbr@usp.br
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Abstract

The mechanisms involved in kidney disturbances during development, induced by vitamin D3 deficiency in female rats, that persist into adulthood were evaluated in this study. Female offspring from mothers fed normal (control group, n=8) or vitamin D-deficient (Vit.D-, n=10) diets were used. Three-month-old rats had their systolic blood pressure (SBP) measured and their blood and urine sampled to quantify vitamin D3 (Vit.D3), creatinine, Na+, Ca+2 and angiotensin II (ANGII) levels. The kidneys were then removed for nitric oxide (NO) quantification and immunohistochemical studies. Vit.D- pups showed higher SBP and plasma ANGII levels in adulthood (P<0.05) as well as decreased urine osmolality associated with increases in urinary volume (P<0.05). Decreased expression of JG12 (renal cortex and glomeruli) and synaptopodin (glomeruli) as well as reduced renal NO was also observed (P<0.05). These findings showed that renal disturbances in development in pups from Vit.D- mothers observed in adulthood may be related to the development of angiogenesis, NO and ANGII alterations.

Keywords

kidney developmentrenin angiotensin systemvitamin D deficiency
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 4 , August 2019 , pp. 497 - 501
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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