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Amygdala – and serum – neurotrophic factor levels depend on rearing condition in male rats

Part of: French DOHaD

Published online by Cambridge University Press:  27 March 2018

S. Babri ,
G. Mohaddes  and
B. Mosaferi
S. Babri
Affiliation:
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
G. Mohaddes
Affiliation:
Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
B. Mosaferi*
Affiliation:
Department of Basic Sciences, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
*
Author for correspondence: B. Mosaferi, Department of Basic Sciences, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, East Azerbaijan 51666-14766, Iran. E-mail: b.mosaferi82@gmail.com; Mosaferib@tbzmed.ac.ir
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Abstract

Early life experiences could determine brain and behavioral development. Neurotrophic factors are likely to mediate the effects of the experience on brain structures and function. Brain-derived neurotrophic factor (BDNF) plays a central role in psychiatric disorders. To investigate the effects of early rearing condition on the amygdala – and serum – BDNF levels, we reared male Wistar rats from weaning (postnatal days 21) to adulthood (postnatal days 119) in three different rearing conditions: (1) enriched, (2) standard and (3) isolated. We found that long-term post-weaning environmental enrichment leads to lower amygdala – and serum – BDNF levels as well as lower brain weights. Grouped rearing in standard laboratory cages enhanced body weight. Thus, early rearing condition might play a crucial role in adult healthiness by predetermining individual BDNF profiles.

Keywords

amygdalabrain-derived neurotrophic factorearly life experiencesenvironmental enrichmentpsychiatric disorders
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 4: Themed Issue: French DOHaD , August 2018 , pp. 377 - 380
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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References

1 Branchi, I, Cirulli, F. Early experiences: building up the tools to face the challenges of adult life. Dev Psychobiol. 2014; 56, 1661–1674.Google Scholar
2 Romeo, RD, Patel, R, Pham, L, So, VM. Adolescence and the ontogeny of the hormonal stress response in male and female rats and mice. Neurosci Biobehav Rev. 2016; 70, 206–216.Google Scholar
3 Baroncelli, L, Braschi, C, Spolidoro, M, et al. Nurturing brain plasticity: impact of environmental enrichment. Cell Death Differ. 2010; 17, 1092–1103.Google Scholar
4 Branchi, I, Francia, N, Alleva, E. Epigenetic control of neurobehavioural plasticity: the role of neurotrophins. Behav Pharmacol. 2004; 15, 353–362.Google Scholar
5 Park, H, Poo, M-M. Neurotrophin regulation of neural circuit development and function. Nat Rev Neurosci. 2013; 14, 7–23.Google Scholar
6 Levi-Montalcini, R. Tissue and nerve growth promoting factors. Biological aspects of specific growth promoting factors. Proc R Soc Med. 1965; 58, 357–360.Google Scholar
7 Boulle, F, Van den Hove, D, Jakob, S, et al. Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol Psychiatry. 2011; 17, 584–596.Google Scholar
8 Schumann, CM, Bauman, MD, Amaral, DG. Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders. Neuropsychologia. 2011; 49, 745–759.Google Scholar
9 Mosaferi, B, Babri, S, Mohaddes, G, Khamnei, S, Mesgari, M. Post-weaning environmental enrichment improves BDNF response of adult male rats. Int J Dev Neurosci. 2015; 46, 108–114.Google Scholar
10 Ravenelle, R, Santolucito, HB, Byrnes, EM, Byrnes, JJ, Donaldson, ST. Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats. Neuroscience. 2014; 270, 76–87.Google Scholar
11 Leckie, RL, Oberlin, LE, Voss, MW, et al. BDNF mediates improvements in executive function following a 1-year exercise intervention. Front Hum Neurosci. 2014; 8, 985.Google Scholar
12 Sen, S, Duman, R, Sanacora, G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry. 2008; 64, 527–532.Google Scholar
13 Vinogradov, S, Fisher, M, Holland, C, et al. Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biol Psychiatry. 2009; 66, 549–553.Google Scholar
14 Neeper, SA, Gomez-Pinilla, F, Choi, J, Cotman, CW. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 1996; 726, 49–56.Google Scholar
15 Fa, M, Xia, L, Anunu, R, Kehat, O, Kriebel, M, Volkmer, H, Richter-Levin, G. Stress modulation of hippocampal activity--spotlight on the dentate gyrus. Neurobiol Learn Mem. 2014; 112, 53–60.Google Scholar
16 Mosaferi, B, Babri, S, Ebrahimi, H, Mohaddes, G. Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats. Physiology & Behavior. 2015; 142, 131–136.Google Scholar
17 Vedovelli, K, Silveira, E, Velho, E, et al. Effects of increased opportunity for physical exercise and learning experiences on recognition memory and brain-derived neurotrophic factor levels in brain and serum of rats. Neuroscience. 2011; 199, 284–291.Google Scholar
18 Chareyron, LJ, Banta Lavenex, P, Amaral, DG, Lavenex, P. Stereological analysis of the rat and monkey amygdala. J Comp Neurol. 2011; 519, 3218–3239.Google Scholar
19 Lakshminarasimhan, H, Chattarji, S. Stress leads to contrasting effects on the levels of brain derived neurotrophic factor in the hippocampus and amygdala. PLoS one. 2012; 7, e30481.Google Scholar
20 Gass, P, Hellweg, R. Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker for affective disorders? Int J Neuropsychopharmacol. 2010; 13, 1–4.Google Scholar
21 Rasmussen, P, Brassard, P, Adser, H, et al. Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise. Exp Physiol. 2009; 94, 1062–1069.Google Scholar
22 Du, X, Wu, YC, Hill, RA. BDNF–TrkB signaling as a therapeutic target in neuropsychiatric disorders. J Receptor Ligand Channel Res. 2014; 7, 61–79.Google Scholar
23 Barnard, N, Hou, S. Inherent stress: The tough life in lab routine. Lab Anim. 1988; 17, 21–27.Google Scholar
24 Würbel, H. Ideal homes? Housing effects on rodent brain and behaviour. Trends Neurosci. 2001; 24, 207–211.Google Scholar
25 Luo, KR, Hong, CJ, Liou, YJ, et al. Differential regulation of neurotrophin S100B and BDNF in two rat models of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34, 1433–1439.Google Scholar
26 Elfving, B, Plougmann, PH, Muller, HK, et al. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. Int J Neuropsychopharmacol. 2010; 13, 563–572.Google Scholar
27 Zhao, H, Alam, A, San, C-Y, et al. Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments. Brain Res. 2017; 1665, 1–21.Google Scholar
28 Autry, AE, Adachi, M, Cheng, P, Monteggia, LM. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry. 2009; 66, 84–90.Google Scholar
29 Girbovan, C, Plamondon, H. Environmental enrichment in female rodents: Considerations in the effects on behavior and biochemical markers. Behav Brain Res. 2013; 253, 178–190.Google Scholar
30 Abbott, CR, Small, CJ, Sajedi, A, et al. The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat. Int J Obes. 2006; 30, 288–292.Google Scholar
31 Ohdo, S. Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption. Adv Drug Deliv Rev. 2010; 62, 859–875.Google Scholar
32 Bennett, EL, Rosenzweig, MR, Diamond, MC, Morimoto, H, Hebert, M. Effects of successive environments on brain measures. Physiology and Behavior. 1974; 12, 621–631.Google Scholar
33 Simpson, J, Kelly, JP. The impact of environmental enrichment in laboratory rats--behavioural and neurochemical aspects. Behav Brain Res. 2011; 222, 246–264.Google Scholar
34 Kolb, B, Mychasiuk, R, Muhammad, A, et al. Experience and the developing prefrontal cortex. Proc Natl Acad Sci. 2012; 109(Supplement 2), 17186–17193.Google Scholar
35 Churchill, JD, Grossman, AW, Irwin, SA, et al. A converging-methods approach to fragile X syndrome. Dev Psychobiol. 2002; 40, 323–338.Google Scholar
36 Comery, TA, Harris, JB, Willems, PJ, et al. Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Proc Natl Acad Sci. 1997; 94, 5401–5404.Google Scholar
37 Hall, FS, Perona, MT. Have studies of the developmental regulation of behavioral phenotypes revealed the mechanisms of gene–environment interactions? Physiol Behav. 2012; 107, 623–640.Google Scholar