Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-10T06:59:53.825Z Has data issue: false hasContentIssue false
  • English
  • Français

Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

Published online by Cambridge University Press:  30 April 2015

C. R. Pessanha ,
B. Ferolla da Camara Boueri ,
L. Rodrigues da Costa ,
M. Rocha Ferreira ,
H. Saldanha Melo ,
M. Duque Coutinho de Abreu ,
L. Rozeno Pessoa ,
P. C. Alves da Silva ,
A. D’Avila Pereira  and
D. Cavalcante Ribeiro
...Show all authors
C. R. Pessanha
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
B. Ferolla da Camara Boueri
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
L. Rodrigues da Costa
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
M. Rocha Ferreira
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
H. Saldanha Melo
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
M. Duque Coutinho de Abreu
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
L. Rozeno Pessoa
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
P. C. Alves da Silva
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
A. D’Avila Pereira
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
D. Cavalcante Ribeiro
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
J. Azevedo de Meneses
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
C. A. Soares da Costa
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
G. T. Boaventura*
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
*
*Address for correspondence: G. T. Boaventura, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Rua Mário Santos Braga 30, Niterói, RJ 24015-110, Brazil. (Email gilsontb@gmail.com)
Get access Rights & Permissions [Opens in a new window]

Abstract

The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, some of the pups were evaluated (C21 v. EW21). After 21 days, control pups (C60) were fed a control diet. EW pups were divided into those fed a control diet (EWC60), those given flaxseed flour (EWFF60), and those given flaxseed oil (EWFO60) until 60 days. EW21 showed lower body and absolute brain mass and higher relative brain mass. At 60 days, EWC60 and EWFO60 had lower body mass. With regard to relative brain mass, EWC60 was heavier; EWFO60 had lower values compared with EWC60 and higher values compared with C60 and EWFF60. These results indicated that flaxseed flour, in comparison with flaxseed oil, contributes to brain development after EW.

Keywords

brainearly weaningflaxseedrat
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Issue 4 , August 2015 , pp. 268 - 271
Check for updates
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Belfort, MB, Rifas-Shiman, SL, Rich-Edwards, JW, et al. Infant growth and child cognition at 3 years of age. Pediatrics. 2008; 122, 689–695.CrossRefGoogle ScholarPubMed
2. Kafouri, S, Kramer, M, Leonard, G, et al. Breastfeeding and brain structure in adolescence. Int J Epidemiol. 2013; 42, 150–159.CrossRefGoogle ScholarPubMed
3. Deoni, SCL, Dean, DC, Piryatinsky, I, et al. Breastfeeding and early white matter development: a cross-sectional study. Neuroimage. 2013; 82, 77–86.CrossRefGoogle ScholarPubMed
4. Almeida, KCL, Boavetura, GT, Guzmán-Silva, MA. Influence of omega-3 fatty acids from flaxseed (Linum usitatissimum) on the brain development of newborn rats. Nutr Hosp. 2011; 26, 991–996.Google Scholar
5. Meneses, JA, Lopes, CAJ, Velarde, LGC, Boaventura, GT. Behavioral analysis of Wistar rats fed with a flaxseed based diet added to an environmental enrichment. Nutr Hosp. 2011; 26, 716–721.Google Scholar
6. Fishbeck, KL, Rasmussen, KM. Effect of repeated cycles on maternal nutritional status, lactational performance and litter growth in ad libitum-fed and chronically food-restricted rat. J Nutr. 1987; 117, 1967–1975.CrossRefGoogle Scholar
7. Reeves, PG. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr. 1997; 127, 838–841.Google Scholar
8. McInerny, TK. Breastfeeding, early brain development, and epigenetics – getting children off to their best start. Breastfeed Med. 2014; 9, 333–334.Google Scholar
9. Herba, CM, Roza, S, Govaert, P, et al. Breastfeeding and early brain development: the generation R study. Matern Child Nutr. 2013; 9, 332–349.Google Scholar
10. Innis, SM. Impact of maternal diet on human milk composition and neurological development of infants. Am J Clin Nutr. 2014; 99, 734–741.CrossRefGoogle ScholarPubMed
11. Bernard, JY, Agostini, M, Forhan, A, et al. The dietary n6:n3 fatty acid ratio during pregnancy is inversely associated with child neurodevelopment in the EDEN mother-child cohort1–3. J Nutr. 2013; 143, 1481–1488.Google Scholar
12. Oliveira, LS, Silva, LP, Silva, AI, et al. Effects of early weaning on the circadian rhythm and behavioral satiety sequence in rats. Behav Processes. 2011; 86, 119–124.Google Scholar
13. Younes-Rapozo, V, de Moura, EG, Lima, NS, et al. Early weaning is associated with higher neuropeptide Y (NPY) and lower cocaine- and amphetamine-regulated transcript (CART) expressions in the paraventricular (PVN) in adulthood. Br J Nutr. 2012; 108, 2286–2295.CrossRefGoogle ScholarPubMed
14. Fraga, MC, de Moura, EG, Lima, NS, et al. Anxiety-like, novelty-seeking and memory/learning behavioral traits in male Wistar rats submitted to early weaning. Physiol Behav. 2014; 124, 100–106.CrossRefGoogle ScholarPubMed
15. Stratton, MS, Staros, M, Budefeld, T, et al. Embryonic GABAB receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice. Plos One. 2014; 9, e106015.CrossRefGoogle ScholarPubMed
16. Freedman, LS, Samuels, S, Fish, I, et al. Sparing of the brain in neonatal undernutrition: amino acid transport and incorporation into brain and muscle. Science. 1980; 207, 902–904.CrossRefGoogle ScholarPubMed
17. Giussani, DA. The vulnerable developing brain. Proc Natl Acad Sci USA. 2011; 108, 2641–2642.CrossRefGoogle ScholarPubMed
18. Morgane, PJ, Austin-Lafrance, R, Bronzino, J, et al. Prenatal malnutrition and development of the brain. Neurosci Biobehav Rev. 1993; 17, 91–128.Google Scholar
19. Costa, CAS, Alves, EG, Gonzalez, GPL, et al. Evaluation of body development, fat mass and lipid profile in rats fed with high-PUFA and -MUFA diets, after neonatal malnutrition. Br J Nutr. 2009; 101, 1639–1644.Google Scholar
20. Bieswal, F, Ahn, MT, Reusens, B, et al. The importance of catch-up growth after early malnutrition for the programming of obesity in male rat. Obesity. 2006; 14, 1330–1343.Google Scholar
21. Lima, NS, de Moura, EG, Passos, MC, et al. Early weaning causes undernutrition for a short period and programmes some metabolic syndrome components and leptina resistance in adult rat offspring. Br J Nutr. 2011; 105, 1405–1413.CrossRefGoogle Scholar
22. Ribeiro, DC, Silva, PCA, Pereira, AD, et al. Assessments of body composition and bone parameters of lactating rats treated with diet containing flaxseed meal (Linum usitatissinum) during post-weaning period. Nutr Hosp. 2014; 30, 366–371.Google Scholar