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Effects of maternal periconceptional undernutrition in sheep on offspring glucose–insulin axis function into adulthood

Published online by Cambridge University Press:  20 November 2020

Mark H. Oliver Open the ORCID record for Mark H. Oliver [Opens in a new window] ,
Frank H. Bloomfield Open the ORCID record for Frank H. Bloomfield [Opens in a new window] ,
Amita Bansal Open the ORCID record for Amita Bansal [Opens in a new window] ,
Hui Hui Phua ,
Eric B. Thorstensen ,
Jane E. Harding  and
Anne L. Jaquiery
Mark H. Oliver
Affiliation:
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
Frank H. Bloomfield
Affiliation:
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
Amita Bansal
Affiliation:
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
Hui Hui Phua
Affiliation:
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
Eric B. Thorstensen
Affiliation:
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
Jane E. Harding
Affiliation:
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
Anne L. Jaquiery*
Affiliation:
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
*
Address for correspondence: Anne L. Jaquiery, Liggins Institute, University of Auckland, Private Bag 92019, Auckland1142, New Zealand. Email: a.jaquiery@auckland.ac.nz
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Abstract

Maternal periconceptional undernutrition (PCUN) affected fetal pancreatic maturation in late gestation lambs and impaired glucose tolerance in 10-month-old sheep. To examine the importance of the timing of maternal undernutrition around conception, a further cohort was born to PCUN ewes [undernourished for 61 d before conception (PreC), 30 d after conception (PostC), or 61 d before until 30 d after conception (PrePostC)], or normally fed ewes (Control) (n = 15–20/group). We compared glucose tolerance, insulin secretion, and sensitivity at 36 months of age. We also examined protein expression of insulin signalling proteins in muscle from these animals and in muscle from a fetal cohort (132 d of gestation; n = 7–10/group). Adult PostC and PrePostC sheep had higher glucose area under the curve than Controls (P = 0.07 and P = 0.02, respectively), whereas PreC sheep were similar to Controls (P = 0.97). PostC and PrePostC had reduced first-phase insulin secretion compared with Control (P = 0.03 and P = 0.02, respectively). PreC was similar to Control (P = 0.12). Skeletal muscle SLC2A4 protein expression in PostC and PrePostC was increased 19%–58% in fetuses (P = 0.004), but decreased 39%–43% in adult sheep (P = 0.003) compared with Controls. Consistent with this, protein kinase C zeta (PKCζ) protein expression tended to be increased in fetal (P = 0.09) and reduced in adult (P = 0.07) offspring of all PCUN ewes compared with Controls. Maternal PCUN alters several aspects of offspring glucose homeostasis into adulthood. These findings suggest that maternal periconceptional nutrition has a lasting impact on metabolic homeostasis of the offspring.

Keywords

Undernutritionglucose toleranceinsulin secretioninsulin sensitivity
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 5 , October 2021 , pp. 714 - 720
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Copyright
© The Author(s), 2020. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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Footnotes

†

Current address: ANU Medical School, John Curtin School of Medical Research, ANU College of Health and Medicine, The Australian National University, Canberra, ACT, 2601, Australia.

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