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Endothelial dysfunction in individuals born after fetal growth restriction: cardiovascular and renal consequences and preventive approaches

Published online by Cambridge University Press:  02 May 2017

C. Yzydorczyk ,
J. B. Armengaud ,
A. C. Peyter ,
H. Chehade ,
F. Cachat ,
C. Juvet ,
B. Siddeek ,
S. Simoncini ,
F. Sabatier  and
F. Dignat-George
...Show all authors
C. Yzydorczyk*
Affiliation:
Department Woman-Mother-Child, Clinic of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
J. B. Armengaud
Affiliation:
Department Woman-Mother-Child, Clinic of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
A. C. Peyter
Affiliation:
Department Woman-Mother-Child, Clinic of Neonatology, Neonatal Research Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
H. Chehade
Affiliation:
Department Woman-Mother-Child, Clinic of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Department Woman-Mother-Child, Clinic of Pediatrics, Division of Pediatric Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
F. Cachat
Affiliation:
Department Woman-Mother-Child, Clinic of Pediatrics, Division of Pediatric Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
C. Juvet
Affiliation:
Department Woman-Mother-Child, Clinic of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Department Woman-Mother-Child, Clinic of Pediatrics, Division of Pediatric Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
B. Siddeek
Affiliation:
Department Woman-Mother-Child, Clinic of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
S. Simoncini
Affiliation:
VRCM, Aix Marseille University, UMR S INSERM 1076, Faculté de Pharmacie, Marseille, France
F. Sabatier
Affiliation:
VRCM, Aix Marseille University, UMR S INSERM 1076, Faculté de Pharmacie, Marseille, France
F. Dignat-George
Affiliation:
VRCM, Aix Marseille University, UMR S INSERM 1076, Faculté de Pharmacie, Marseille, France
D. Mitanchez
Affiliation:
Division of Neonatology, Department of Perinatology, Armand Trousseau Hospital, APHP, Paris, France Sorbonne University, UPMC University Paris 06, Paris, France
U. Simeoni
Affiliation:
Department Woman-Mother-Child, Clinic of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
*
*Address for correspondence: C. Yzydorczyk, Department Woman-Mother-Child, Clinic of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 27, 1011 Lausanne, Switzerland.(Email catherine.yzydorczyk@chuv.ch)
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Abstract

Individuals born after intrauterine growth restriction (IUGR) have an increased risk of perinatal morbidity/mortality, and those who survive face long-term consequences such as cardiovascular-related diseases, including systemic hypertension, atherosclerosis, coronary heart disease and chronic kidney disease. In addition to the demonstrated long-term effects of decreased nephron endowment and hyperactivity of the hypothalamic–pituitary–adrenal axis, individuals born after IUGR also exhibit early alterations in vascular structure and function, which have been identified as key factors of the development of cardiovascular-related diseases. The endothelium plays a major role in maintaining vascular function and homeostasis. Therefore, it is not surprising that impaired endothelial function can lead to the long-term development of vascular-related diseases. Endothelial dysfunction, particularly impaired endothelium-dependent vasodilation and vascular remodeling, involves decreased nitric oxide (NO) bioavailability, impaired endothelial NO synthase functionality, increased oxidative stress, endothelial progenitor cells dysfunction and accelerated vascular senescence. Preventive approaches such as breastfeeding, supplementation with folate, vitamins, antioxidants, L-citrulline, L-arginine and treatment with NO modulators represent promising strategies for improving endothelial function, mitigating long-term outcomes and possibly preventing IUGR of vascular origin. Moreover, the identification of early biomarkers of endothelial dysfunction, especially epigenetic biomarkers, could allow early screening and follow-up of individuals at risk of developing cardiovascular and renal diseases, thus contributing to the development of preventive and therapeutic strategies to avert the long-term effects of endothelial dysfunction in infants born after IUGR.

Keywords

cardiovascular diseasechronic renal diseasesDOHaDendothelial dysfunctionintrauterine growth restriction
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 4: Themed Issue: Assisted Reproductive Treatments (ART) and DOHAD , August 2017 , pp. 448 - 464
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

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Footnotes

†

These authors contributed equally to this work.

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