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Growth from birth to 6 months of infants with and without intrauterine preeclampsia exposure

Published online by Cambridge University Press:  12 May 2021

Megan L. Gow Open the ORCID record for Megan L. Gow [Opens in a new window] ,
Lynne Roberts ,
Amanda Henry ,
Gregory Davis ,
George Mangos ,
Franziska Pettit ,
Joseph M. Khouri ,
Ana Dosen ,
Mark A. Brown  and
Maria E. Craig
Megan L. Gow*
Affiliation:
Women’s and Children’s Health, St George Hospital, Sydney, Australia University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
Lynne Roberts
Affiliation:
Women’s and Children’s Health, St George Hospital, Sydney, Australia St George and Sutherland Clinical School, University of New South Wales, Sydney, Australia
Amanda Henry
Affiliation:
Women’s and Children’s Health, St George Hospital, Sydney, Australia School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia The George Institute for Global Health, Sydney, Australia
Gregory Davis
Affiliation:
Women’s and Children’s Health, St George Hospital, Sydney, Australia School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
George Mangos
Affiliation:
St George and Sutherland Clinical School, University of New South Wales, Sydney, Australia Renal Medicine, St George Hospital, Sydney, Australia
Franziska Pettit
Affiliation:
St George and Sutherland Clinical School, University of New South Wales, Sydney, Australia Renal Medicine, St George Hospital, Sydney, Australia
Joseph M. Khouri
Affiliation:
School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
Ana Dosen
Affiliation:
School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
Mark A. Brown
Affiliation:
St George and Sutherland Clinical School, University of New South Wales, Sydney, Australia Renal Medicine, St George Hospital, Sydney, Australia
Maria E. Craig
Affiliation:
Women’s and Children’s Health, St George Hospital, Sydney, Australia University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
*
Address for correspondence: Megan L. Gow, Women’s and Children’s Health, St George HospitalSydney, NSW2217, Australia. Email: megan.gow@health.nsw.gov.au
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Abstract

Intrauterine preeclampsia exposure affects the lifelong cardiometabolic health of the child. Our study aimed to compare the growth (from birth to 6 months) of infants exposed to either a normotensive pregnancy or preeclampsia and explore the influence of being born small for gestational age (SGA). Participants were children of women participating in the Post-partum, Physiology, Psychology and Paediatric follow-up cohort study. Birth and 6-month weight and length z-scores were calculated for term and preterm (<37 weeks) babies, and change in weight z-score, rapid weight gain (≥0.67 increase in weight z-score) and conditional weight gain z-score were calculated. Compared with normotensive exposed infants (n = 298), preeclampsia exposed infants (n = 84) were more likely to be born SGA (7% versus 23%; P < 0.001), but weight gain from birth to 6 months, by any measure, did not differ between groups. Infants born SGA, irrespective of pregnancy exposure, were more likely to have rapid weight gain and had greater increases in weight z-score compared with those not born SGA. Preeclampsia exposed infants born SGA may benefit from interventions designed to prevent future cardiometabolic disease.

Keywords

Growthinfantspreeclampsiasmall for gestational age
Type
Brief Reports
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 2 , April 2022 , pp. 151 - 155
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Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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