Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-11T09:19:03.139Z Has data issue: false hasContentIssue false
  • English
  • Français

Long-term effects of early overfeeding and food restriction during puberty on cardiac remodeling in adult rats

Part of: DOHaD Research in Latin-American

Published online by Cambridge University Press:  11 June 2020

Letícia Chavaglia Cavalet Open the ORCID record for Letícia Chavaglia Cavalet [Opens in a new window] ,
Larissa Cristina dos Santos Ribeiro ,
Gustavo Bergoli Rosa ,
Kássia Kristina Sousa ,
Aryanne Batista Soares de Melo ,
Dhiógenes Balsanufo Taveira Campos ,
Lucas Araújo Ferreira ,
Nathalia Oda Amaral ,
Yasmin Teixeira Viana Calisto  and
Alessandra Gisele de Castro
...Show all authors
Letícia Chavaglia Cavalet
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Larissa Cristina dos Santos Ribeiro
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Gustavo Bergoli Rosa
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Kássia Kristina Sousa
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Aryanne Batista Soares de Melo
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Dhiógenes Balsanufo Taveira Campos
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Lucas Araújo Ferreira
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Nathalia Oda Amaral
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Yasmin Teixeira Viana Calisto
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Alessandra Gisele de Castro
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Carlos Henrique de Castro
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Gustavo Rodrigues Pedrino
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Rodrigo Mello Gomes*
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
*
Address for correspondence: Rodrigo Mello Gomes, Laboratory of Endocrine Physiology and Metabolism (LabFEM), Department of Physiological Sciences (DCiF) – Biological Science Institute II (ICB-II), room 101, Federal University of Goiás (UFG) – Campus II, Esperança Avenue s/n, CEP: 74690-900, Goiânia, GO, Brazil. Email: rodrigomellogomes@hotmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Nutritional disorders during the perinatal period cause cardiometabolic dysfunction, which is observable in the early overfeeding (EO) experimental model. Therefore, severe caloric restriction has the potential of affecting homeostasis through the same epigenetic mechanisms, and its effects need elucidation. This work aims to determine the impact of food restriction (FR) during puberty in early overfed obese and non-obese animals in adult life. Three days after delivery (PN3), Wistar rats were separated into two groups: normal litter (NL; 9 pups) and small litter (SL; 3 pups). At PN30, some offspring were subjected to FR (50%) until PN60, or maintained with free access to standard chow. NL and SL animals submitted to food restriction (NLFR and SLFR groups) were kept in recovery with free access to standard chow from PN60 until PN120. Body weight and food intake were monitored throughout the experimental period. At PN120 cardiovascular parameters were analyzed and the animals were euthanized for sample collection. SLNF and SLFR offspring were overweight and had increased adiposity. Differences in blood pressure were observed only between obese and non-obese animals. Obese and FR animals have cardiac remodeling showing cardiomyocyte hypertrophy and the presence of interstitial and perivascular fibrosis. FR animals also show increased expression of AT1 and AT2 receptors and of total ERK and p-ERK. The present study showed that EO leads to the obese phenotype and cardiovascular disruptions. Interestingly, we demonstrated that severe FR during puberty leads to cardiac remodeling.

Keywords

Obesitycardiometabolic programmingearly overfeedingfood restrictionrenin–angiotensin systemhypertension
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 5 , October 2020 , pp. 492 - 498
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Fernandez-Twinn, DS, Ozanne, SE.Early life nutrition and metabolic programming. Ann N Y Acad Sci [Internet]. 2010; 1212 (1), 78–96. Available from: http://doi.wiley.com/10.1111/j.1749-6632.2010.05798.xCrossRefGoogle ScholarPubMed
Habbout, A, Li, N, Rochette, L, Vergely, C.Postnatal overfeeding in rodents by litter size reduction induces major short- and long-term pathophysiological consequences. J Nutr. 2013; 143 (5), 553–562.10.3945/jn.112.172825CrossRefGoogle Scholar
de Souza Rodrigues Cunha, AC, Pereira, RO, dos Santos Pereira, MJ, et al.Long-term effects of overfeeding during lactation on insulin secretion – the role of GLUT-2. J Nutr Biochem [Internet]. 2009; 20 (6), 435–442. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0955286308001101 10.1016/j.jnutbio.2008.05.002CrossRefGoogle Scholar
Barker, DJ, Osmond, C, Golding, J, Kuh, D, Wadsworth, ME.Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ [Internet]. 1989; 298 (6673), 564–567. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2495113 10.1136/bmj.298.6673.564CrossRefGoogle ScholarPubMed
Barker, DJ, Osmond, C, Law, CM.The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health [Internet]. 1989; 43 (3), 237–240. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2607302 10.1136/jech.43.3.237CrossRefGoogle ScholarPubMed
Barker, DJ, Winter, PD, Osmond, C, Margetts, B, Simmonds, SJ.Weight in infancy and death from ischaemic heart disease. Lancet (London, England) [Internet]. 1989; 2 (8663), 577–580. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2570282 10.1016/S0140-6736(89)90710-1CrossRefGoogle ScholarPubMed
Klump, KL.Puberty as a critical risk period for eating disorders: a review of human and animal studies. Horm Behav [Internet]. 2013 Jul; 64 (2), 399–410. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0018506X13000548 10.1016/j.yhbeh.2013.02.019CrossRefGoogle ScholarPubMed
Moreno Villares, JM. Los mil primeros días de vida y la prevención de la enfermedad en el adulto. Nutr Hosp [Internet]. 2016 Jul 12; Available from: http://revista.nutricionhospitalaria.net/index.php/nh/article/view/337CrossRefGoogle Scholar
Mattson, MP.Hormesis defined. Ageing Res Rev. 2008; 7 (1), 1–7.CrossRefGoogle ScholarPubMed
Mattson, MP.Dietary factors, hormesis and health. Ageing Res Rev. 2008; 7 (1), 43–48.10.1016/j.arr.2007.08.004CrossRefGoogle ScholarPubMed
Speakman, JR, Mitchell, SE.Caloric restriction. Mol Aspects Med [Internet]. 2011; 32 (3), 159–221. Available from: http://linkinghub.elsevier.com/retrieve/pii/S009829971100032X 10.1016/j.mam.2011.07.001CrossRefGoogle ScholarPubMed
Lovren, F, Teoh, H, Verma, S.Obesity and atherosclerosis: mechanistic insights. Can J Cardiol [Internet]. 2015; 31 (2), 177–183. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0828282X14016213 10.1016/j.cjca.2014.11.031CrossRefGoogle ScholarPubMed
Yiannikouris, F, Gupte, M, Putnam, K, et al.Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice. Hypertension. 2012; 60 (6), 1524–1530.CrossRefGoogle ScholarPubMed
Santos, RD, Sociedade Brasileira de Cardiologia. [III Brazilian guidelines on dyslipidemias and guideline of atherosclerosis prevention from Atherosclerosis Department of Sociedade Brasileira de Cardiologia]. Arq Bras Cardiol [Internet]. 2001; 77 (Suppl 3), 1–48. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11781591CrossRefGoogle Scholar
Yamazaki, T, Komuro, I, Shiojima, I, Yazaki, Y.The renin-angiotensin system and cardiac hypertrophy. Heart [Internet]. 1996; 76 (3 Suppl 3), 33–35. Available from: http://heart.bmj.com/cgi/doi/10.1136/hrt.76.3_Suppl_3.33CrossRefGoogle ScholarPubMed
Xu, J, Carretero, OA, Liu, Y-HH, et al.Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice. Hypertension. 2002; 40 (3), 244–250.10.1161/01.HYP.0000029095.23198.ADCrossRefGoogle ScholarPubMed
Santos, RAS, Sampaio, WO, Alzamora, AC, et al.The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7). Physiol Rev [Internet]. 2018; 98 (1), 505–553. Available from: http://www.physiology.org/doi/10.1152/physrev.00023.2016CrossRefGoogle Scholar
Zhang, F, Tang, H, Sun, S, et al.Angiotensin-(1–7) induced vascular relaxation in spontaneously hypertensive rats. Nitric Oxide [Internet]. 2019; 88, 1–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1089860319300400CrossRefGoogle ScholarPubMed
Shimizu, T, Liao, JK. Rho kinases and cardiac remodeling. Circ J [Internet]. 2016; 80 (7), 1491–1498. Available from: https://www.jstage.jst.go.jp/article/circj/80/7/80_CJ-16-0433/_article 10.1253/circj.CJ-16-0433CrossRefGoogle Scholar
de Oliveira, JC, de Moura, EG, Miranda, RA, et al.Low-protein diet in puberty impairs testosterone output and energy metabolism in male rats. J Endocrinol [Internet]. 2018; 237 (3), 243–254. Available from: https://joe.bioscientifica.com/view/journals/joe/237/3/JOE-17-0606.xmlCrossRefGoogle ScholarPubMed
de Oliveira, JC, Lisboa, PC, de Moura, EG, et al.Poor pubertal protein nutrition disturbs glucose-induced insulin secretion process in pancreatic islets and programs rats in adulthood to increase fat accumulation. J Endocrinol [Internet]. 2013; 216 (2), 195–206. Available from: https://joe.bioscientifica.com/view/journals/joe/216/2/195.xmlCrossRefGoogle ScholarPubMed
Lumey, L, Stein, AD, Kahn, HS, et al. Cohort profile: the Dutch Hunger Winter families study. Int J Epidemiol. 2007; 36 (6), 1196–1204. Available from: https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dym126CrossRefGoogle Scholar
Aroor, AR, DeMarco, VG.Oxidative stress and obesity: the chicken or the egg? Diabetes [Internet]. 2014; 63 (7), 2216–2218. Available from: http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db14-0424CrossRefGoogle ScholarPubMed
Junior, MDF, Cavalcante, KVN, Ferreira, LA, et al.Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats. Life Sci. 2019; 226 (March), 173–184.10.1016/j.lfs.2019.04.018CrossRefGoogle ScholarPubMed
Ferrante, AW.Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med [Internet]. 2007; 262 (4), 408–414. Available from: http://doi.wiley.com/10.1111/j.1365-2796.2007.01852.xCrossRefGoogle ScholarPubMed
Ramon-Krauel, M, Pentinat, T, Bloks, VW, et al.Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance. FASEB J [Internet]. 2018; 32 (11), 6025–6037. Available from: https://www.fasebj.org/doi/10.1096/fj.201700717RRCrossRefGoogle Scholar