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Maternal high-fat diet consumption programs male offspring to mitigate complications in liver regeneration

Published online by Cambridge University Press:  03 December 2021

T. Fante ,
L. A. P. Simino Open the ORCID record for L. A. P. Simino [Opens in a new window] ,
Marina Figueiredo Fontana ,
Andressa Reginato Open the ORCID record for Andressa Reginato [Opens in a new window] ,
Thomaz Guadagnini Ramalheira ,
Hosana Gomes Rodrigues ,
Patricia Cristina Lisboa Open the ORCID record for Patricia Cristina Lisboa [Opens in a new window] ,
Egberto Gaspar de Moura Open the ORCID record for Egberto Gaspar de Moura [Opens in a new window] ,
Leticia Martins Ignácio-Souza  and
Marciane Milanski
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T. Fante
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
L. A. P. Simino
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Marina Figueiredo Fontana
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Andressa Reginato
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Thomaz Guadagnini Ramalheira
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Hosana Gomes Rodrigues
Affiliation:
Laboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Patricia Cristina Lisboa
Affiliation:
Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Egberto Gaspar de Moura
Affiliation:
Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Leticia Martins Ignácio-Souza
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Marciane Milanski
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Marcio Alberto Torsoni
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
Adriana Souza Torsoni*
Affiliation:
Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas – UNICAMP, Limeira, São Paulo, Brazil
*
Address for correspondence: Adriana Souza Torsoni, 1300, Pedro Zaccaria St. Laboratory of Metabolic Disorders, FCA – UNICAMP, Limeira, São Paulo13484-350, Brazil. Email: atorsoni@unicamp.br
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Abstract

In the last decades, obesity and nonalcoholic fatty liver disease (NAFLD) have become increasingly prevalent in wide world. Fatty liver can be detrimental to liver regeneration (LR) and offspring of obese dams (HFD-O) are susceptible to NAFLD development. Here we evaluated LR capacity in HFD-O after partial hepatectomy (PHx). HFD-O re-exposed or not to HFD in later life were evaluated for metabolic parameters, inflammation, proliferation, tissue repair markers and survival rate after PHx. Increasing adiposity and fatty liver were observed in HFD-O. Despite lower IL-6 levels, Ki67 labeling, cells in S phase and Ciclin D1/PCNA protein content, a lower impact on survival rate was found after PHx, even when re-exposed to HFD. However, no difference was observed between offspring of control dams (SC-O) and HFD-O after surgery. Although LR impairment is dependent of steatosis development, offspring of obese dams are programmed to be protected from the damage promoted by HFD.

Keywords

Metabolic programmingnonalcoholic fatty liver diseasehigh-fat dietpartial hepatectomy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 5 , October 2022 , pp. 575 - 582
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Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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