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A meta-analysis of neonatal health outcomes from oocyte donation

Published online by Cambridge University Press:  27 November 2015

D. H. Adams ,
R. A. Clark ,
M. J. Davies  and
S. de Lacey
D. H. Adams*
Affiliation:
School of Nursing and Midwifery, Flinders University, Bedford Park, SA, Australia
R. A. Clark
Affiliation:
School of Nursing and Midwifery, Flinders University, Bedford Park, SA, Australia
M. J. Davies
Affiliation:
Robinson Institute, The University of Adelaide, Adelaide, SA, Australia Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, SA, Australia
S. de Lacey
Affiliation:
School of Nursing and Midwifery, Flinders University, Bedford Park, SA, Australia
*
*Address for correspondence: D. H. Adams, School of Nursing and Midwifery, Flinders University, Bedford Park, SA 5042, Australia. (Email: adam0072@flinders.edu.au)
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Abstract

Donated oocytes are a treatment modality for female infertility which is also associated with increased risks of preeclampsia. Subsequently it is important to evaluate if there is concomitant increased risks for adverse neonatal events in donated oocyte neonates. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the perinatal health outcomes of offspring conceived from donor oocytes compared with autologous oocytes. Meta-analysis was performed on comparable outcomes data. Twenty-eight studies were eligible and included in the review, and of these, 23 were included in a meta-analysis. Donor oocyte neonates are at increased risk of being born with low birth weight (<2500 g) [risk ratio (RR): 1.18, 95% confidence interval (CI): 1.14–1.22, P-value (P)<0.00001], very low birth weight (<1500 g) (RR: 1.24, CI: 1.15–1.35, P<0.00001), preterm (<37 weeks) (RR: 1.26, CI: 1.23–1.30, P<0.00001), of lower gestational age (mean difference −0.3 weeks, CI: −0.35 weeks to −0.25 weeks, P<0.00001), and preterm with low birth weight (RR: 1.24, CI: 1.19–1.29, P<0.00001), when compared with autologous oocyte neonates. Conversely, low birth weight outcomes were improved in term donor oocyte neonates (RR: 0.86, CI: 0.8–0.93, P=0.0003). These negative outcomes remained significant when controlling for multiple deliveries. The donor oocyte risk rates are higher than those found in general ART outcomes, are important considerations for the counselling of infertile patients and may also influence the long term health of the offspring.

Keywords

donor conceptionmeta-analysisneonateoocyteoutcome
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 7 , Issue 3: Themed Issue: Ibero-American DOHaD Society , June 2016 , pp. 257 - 272
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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