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Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age

Published online by Cambridge University Press:  20 May 2021

Marisa E. Sala ,
M. Florencia Romero ,
Anabella Romero ,
M. Victoria Fasano ,
Ana M. Varea ,
Patricia Carrera ,
Martín R. Salazar ,
Walter G. Espeche  and
Horacio F. González Open the ORCID record for Horacio F. González [Opens in a new window]
Marisa E. Sala
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
M. Florencia Romero
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
Anabella Romero
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
M. Victoria Fasano
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
Ana M. Varea
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
Patricia Carrera
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina Unidad de Estudios Cardiometabólicos, Servicio de Clínica Médica, Hospital Interzonal General de Agudos “Gral. José de San Martín,” La Plata, Ministerio de Salud de la Provincia de Buenos Aires, 1900La Plata, Buenos Aires, Argentina
Martín R. Salazar
Affiliation:
Unidad de Estudios Cardiometabólicos, Servicio de Clínica Médica, Hospital Interzonal General de Agudos “Gral. José de San Martín,” La Plata, Ministerio de Salud de la Provincia de Buenos Aires, 1900La Plata, Buenos Aires, Argentina
Walter G. Espeche
Affiliation:
Unidad de Estudios Cardiometabólicos, Servicio de Clínica Médica, Hospital Interzonal General de Agudos “Gral. José de San Martín,” La Plata, Ministerio de Salud de la Provincia de Buenos Aires, 1900La Plata, Buenos Aires, Argentina
Horacio F. González*
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
*
Address for correspondence: Horacio F. González, IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Calle 63 n°1069, 1900La Plata, Argentina. Phone/fax: +54 221 4535901 ext. 1767-1409. Email: horaciofgonzalez@gmail.com
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Abstract

Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HDP at six months of age. Participants attended the Health Observatory of Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” during 2018 and 2019. Infant neurodevelopment was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III). Data were analyzed using Chi-square, Student’s t-test and Mann–Whitney test. Of the 132 participating infants, 68 and 64 were born to mothers with and without HDP, respectively. At six months, the prevalence of risk of neurodevelopmental delay was significantly higher in infants born to mothers with than without HDP (27.9% vs. 9.4%; p = 0.008) (odds ratio, 3.71; 95% confidence interval, 1.30; 12.28). In conclusion, infants born to mothers with HDP had three times increased risk of neurodevelopmental delay at six months of age.

Keywords

Infant neurodevelopmenthypertensive disorder of pregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 2 , April 2022 , pp. 197 - 203
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Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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