Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-10T09:55:25.016Z Has data issue: false hasContentIssue false
  • English
  • Français

Relationship between copper and lipids and atherogenic indices soon after birth in Japanese preterm infants of 32–35 weeks

Published online by Cambridge University Press:  20 December 2016

H. Shoji ,
N. Ikeda ,
C. Kojima ,
T. Kitamura ,
H. Suganuma ,
K. Hisata ,
S. Hirayama ,
T. Ueno ,
T. Miida  and
T. Shimizu
H. Shoji*
Affiliation:
Department of Pediatrics and Adolescent Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
N. Ikeda
Affiliation:
Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan
C. Kojima
Affiliation:
Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan
T. Kitamura
Affiliation:
Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan
H. Suganuma
Affiliation:
Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan
K. Hisata
Affiliation:
Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan
S. Hirayama
Affiliation:
Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
T. Ueno
Affiliation:
Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
T. Miida
Affiliation:
Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
T. Shimizu
Affiliation:
Department of Pediatrics and Adolescent Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
*
*Address for correspondence: H. Shoji, Department of Pediatrics and Adolescent Medicine, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. (Email hshoji@juntendo.ac.jp)
Get access Rights & Permissions [Opens in a new window]

Abstract

Several studies have reported association of altered levels of lipids and some trace elements with risk factors for cardiovascular disease development in adulthood. Accordingly, the present study aimed to determine the relationship among the serum levels of copper (Cu), zinc (Zn), lipids, lipoproteins and apolipoproteins in preterm infants through an assessment of atherogenic indices shortly after birth. Blood samples were collected within 20 min of birth from 45 preterm infants with gestational ages ranging from 32 to 35 weeks. Serum Cu, Zn, total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc), apolipoprotein-A1 (apoA1) and apolipoprotein-B (apoB) levels were measured, and the TC/HDLc, LDLc/HDLc and apoB/apoA1 ratios were calculated. Upon determining the correlation between the levels of Cu, Zn and these indices of lipid metabolism, triglyceride (TG) and Cu were found to correlate negatively with birth weight (BW) and the standard deviation (s.d.) score for body weight. Furthermore, Cu levels correlated positively with the TG level and TC/HDLc, LDLc/HDLc and apoB/apoA1 ratios and negatively with the HDLc level and HDLc/apoA1 ratios. However, a stepwise multiple regression analysis indicated that the s.d. score for BW and TG level were significant independent determinants of the Cu level. In contrast, Zn did not correlate with any of these indices. In conclusion, intrauterine growth restriction and the TG level at birth influence Cu levels in preterm infants, whereas atherogenic indices do not affect this parameter.

Keywords

apolipoproteinscopperfetal growth restrictionlipoproteinspreterm infants
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 2 , April 2017 , pp. 256 - 260
Check for updates
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016. This is a work of the U.S. Government and is not subject to copyright protection in the United States. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Skogen, JC, Overland, S. The fetal origins of adult disease: a narrative review of the epidemiological literature. JRSM Short Rep. 2012; 3, 59.Google Scholar
2. Barker, DJ, Gluckman, PD, Godfrey, KM, et al. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993; 341, 938–941.Google Scholar
3. Barker, DJ, Martyn, CN, Osmond, C, et al. Growth in utero and serum cholesterol concentrations in adult life. BMJ. 1993; 307, 1524–1527.Google Scholar
4. Dolphin, PJ, Breckenridge, WC, Dolphin, MA, et al. The lipoproteins of human umbilical cord blood apolipoprotein and lipid levels. Atherosclerosis. 1984; 51, 109–122.CrossRefGoogle ScholarPubMed
5. Lane, DM, McConathy, WJ. Changes in the serum lipids and apolipoproteins in the first four weeks of life. Pediatr Res. 1986; 20, 332–337.CrossRefGoogle ScholarPubMed
6. Webber, LS, Srinivasan, SR, Wattigney, WA, et al. Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study. Am J Epidemiol. 1991; 133, 884–899.Google Scholar
7. Fuentes, RM, Notkola, IL, Shemeikka, S, et al. Tracking of serum total cholesterol during childhood: an 8-year follow-up population-based family study in eastern Finland. Acta Paediatr. 2003; 92, 420–424.Google Scholar
8. Fonnebo, V, Dahl, LB, Moe, PJ, et al. Does VLDL-LDL-cholesterol in cord serum predict future level of lipoproteins? Acta Paediatr Scand. 1991; 80, 780–785.Google Scholar
9. Bastida, S, Sanchez-Muniz, FJ, Cuena, R, et al. High density lipoprotein-cholesterol changes in children with high cholesterol levels at birth. Eur J Pediatr. 2002; 161, 94–98.CrossRefGoogle ScholarPubMed
10. Millan, J, Pinto, X, Munoz, A, et al. Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 2009; 5, 757–765.Google ScholarPubMed
11. Campos, H, Genest, JJ Jr, Blijlevens, E, et al. Low density lipoprotein particle size and coronary artery disease. Arterioscler Thromb. 1992; 12, 187–195.CrossRefGoogle ScholarPubMed
12. Chisolm, GM, Steinberg, D. The oxidative modification hypothesis of atherogenesis: an overview. Free Radic Biol Med. 2000; 28, 1815–1826.Google Scholar
13. Craig, WY, Poulin, SE, Palomaki, GE, et al. Oxidation-related analytes and lipid and lipoprotein concentrations in healthy subjects. Arterioscler Thromb Vasc Biol. 1995; 15, 733–739.Google Scholar
14. Reunanen, A, Knekt, P, Marniemi, J, et al. Serum calcium, magnesium, copper and zinc and risk of cardiovascular death. Eur J Clin Nutr. 1996; 50, 431–437.Google ScholarPubMed
15. Leone, N, Courbon, D, Ducimetiere, P, et al. Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology. 2006; 17, 308–314.Google Scholar
16. Naka, T, Kaneto, H, Katakami, N, et al. Association of serum copper levels and glycemic control in patients with type 2 diabetes. Endocr J. 2013; 60, 393–396.Google Scholar
17. Ferdousi, S, Mia, AR. Serum levels of copper and zinc in newly diagnosed type-2 diabetic subjects. Mymensingh Med J. 2012; 21, 475–478.Google ScholarPubMed
18. Klevay, LM. Coronary heart disease: the zinc/copper hypothesis. Am J Clin Nutr. 1975; 28, 764–774.Google Scholar
19. Yount, NY, McNamara, DJ, Al-Othman, AA, et al. The effect of copper deficiency on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. J Nutr Biochem. 1990; 1, 21–27.CrossRefGoogle ScholarPubMed
20. Itabashi, K, Miura, F, Uehara, R, et al. New Japanese neonatal anthropometric charts for gestational age at birth. Pediatr Int. 2014; 56, 702–708.Google Scholar
21. Bastida, S, Vaquero, MP, Veldhuizen, M, et al. Selected trace elements and minerals in cord blood: association with lipids and lipoproteins at birth. Acta Paediatr. 2000; 89, 1201–1206.Google Scholar
22. Bastida, S, Sanchez-Muniz, FJ, Cuesta, C, et al. Male and female cord blood lipoprotein profile differences throughout the term-period. J Perinat Med. 1997; 25, 184–191.CrossRefGoogle ScholarPubMed
23. Wells, EM, Navas-Acien, A, Apelberg, BJ, et al. Association of selenium and copper with lipids in umbilical cord blood. J Dev Orig Health Dis. 2014; 5, 281–287.Google Scholar
24. Bermudez, L, Garcia-Vicent, C, Lopez, J, et al. Assessment of ten trace elements in umbilical cord blood and maternal blood: association with birth weight. J Transl Med. 2015; 13, 291.Google Scholar
25. Cohen, MS. Fetal and childhood onset of adult cardiovascular diseases. Pediatr Clin North Am. 2004; 51, 1697–1719, x.Google Scholar
26. Woollett, LA. Maternal cholesterol in fetal development: transport of cholesterol from the maternal to the fetal circulation. Am J Clin Nutr. 2005; 82, 1155–1161.Google Scholar
27. Bansal, N, Cruickshank, JK, McElduff, P, et al. Cord blood lipoproteins and prenatal influences. Curr Opin Lipidol. 2005; 16, 400–408.Google Scholar