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Response to an aerobic training intervention in young adults depends on ponderal index at birth

Published online by Cambridge University Press:  04 April 2012

T. D. Brutsaert ,
K. H. Tamvada ,
M. Kiyamu ,
D. D. White  and
T. B. Gage
T. D. Brutsaert*
Affiliation:
Departments of Exercise Science and Anthropology, Syracuse University, Syracuse, NY, USA
K. H. Tamvada
Affiliation:
Department of Anthropology, University at Albany, SUNY, Albany, NY, USA
M. Kiyamu
Affiliation:
Department of Anthropology, University at Albany, SUNY, Albany, NY, USA
D. D. White
Affiliation:
College of Nanoscale Science and Engineering, University at Albany, SUNY, Albany, NY, USA.
T. B. Gage
Affiliation:
Department of Anthropology, University at Albany, SUNY, Albany, NY, USA
*
*Address for correspondence: Dr T. D. Brutsaert, Department of Exercise Science, Syracuse University, 820 Comstock Avenue, 201 Women's Building/Room 201, Syracuse, NY 13244-5040, USA. (Email tdbrutsa@syr.edu)
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Abstract

Poor fetal growth is associated with later-life changes in adult body composition and decrements in muscle strength and morphology. Few studies have investigated the association of poor fetal growth with whole-body exercise. The purpose of this study was to investigate the association of poor fetal growth with the maximal oxygen consumption (VO2max), lactate levels during exercise and the response to aerobic training. Thirty-six college-aged men and women (aged 20.8 ± 0.3 years), born to term (37–42 weeks gestation), were recruited to participate in an 8-week training program. Participants comprised two groups, high ponderal index (HIGHPI) and low ponderal index (LOWPI) (n = 18/group), identified as falling above and below the 10th percentile of the ponderal index (g/cm3)-for-gestational age distribution, respectively. The HIGHPI and LOWPI were matched pair-wise on age, sex, body mass index and pre-study physical activity patterns. The LOWPI and HIGHPI did not differ significantly before training, after training or with a change (Δ) in training VO2max (l/min or ml/min kg/fat-free mass (FFM)). However, LOWPI had significantly lower pre-training lactate levels at similar levels of relative work output (P = 0.016), and significantly smaller decreases in lactate at a fixed level of absolute work after training (P = 0.044). These differences were independent of pre-training aerobic fitness, the change in fitness with training, diet and fuel substrate choice. The lower lactate of untrained LOWPI subjects during exercise could reflect metabolic reprograming due to intrauterine growth restriction, or could be secondary to muscle morphological and/or fiber-type distribution changes that also associate with poor fetal growth.

Keywords

fetal programinghuman performanceintrauterine growth retardationmetabolicmuscleponderal index
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 3 , Issue 6 , December 2012 , pp. 424 - 432
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012 

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References

1.Hales, CN, Barker, DJ, Clark, PM, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991; 303, 1019–1022.Google Scholar
2.Phillips, DI, Barker, DJ, Hales, CN, et al. Thinness at birth and insulin resistance in adult life. Diabetologia. 1994; 37, 150–154.CrossRefGoogle ScholarPubMed
3.Barker, DJ, Martyn, CN, Osmond, C, et al. Growth in utero and serum cholesterol concentrations in adult life. BMJ. 1993; 307, 1524–1527.Google Scholar
4.Maltin, CA, Delday, MI, Sinclair, KD, et al. Impact of manipulations of myogenesis in utero on the performance of adult skeletal muscle. Reproduction. 2001; 122, 359–374.Google Scholar
5.Ward, SS, Stickland, NC. Why are slow and fast muscles differentially affected during prenatal undernutrition? Muscle Nerve. 1991; 14, 259–267.Google Scholar
6.Costello, PM, Rowlerson, A, Astaman, NA, et al. Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development. J Physiol. 2008; 586, 2371–2379.Google Scholar
7.Bauer, R, Gedrange, T, Bauer, K, et al. Intrauterine growth restriction induces increased capillary density and accelerated type I fiber maturation in newborn pig skeletal muscles. J Perinat Med. 2006; 34, 235–242.Google Scholar
8.Labayen, I, Moreno, LA, Blay, MG, et al. Early programming of body composition and fat distribution in adolescents. J Nutr. 2006; 36, 147–152.Google Scholar
9.Eriksson, J, Forsen, T, Tuomilehto, J, et al. Size at birth, fat-free mass and resting metabolic rate in adult life. Horm Metab Res. 2002; 34, 72–76.CrossRefGoogle ScholarPubMed
10.Gale, CR, Martyn, CN, Kellingray, S, et al. Intrauterine programming of adult body composition. J Clin Endocrinol Metab. 2001; 86, 267–272.Google ScholarPubMed
11.Sayer, AA, Cooper, C. Fetal programming of body composition and musculoskeletal development. Early Hum Dev. 2005; 81, 735–744.Google Scholar
12.Kuh, D, Bassey, J, Hardy, R, et al. Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol. 2002; 156, 627–633.Google Scholar
13.Taylor, DJ, Thompson, CH, Kemp, GJ, et al. A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy. Diabetologia. 1995; 38, 1205–1212.Google Scholar
14.Thompson, CH, Sanderson, AL, Sandeman, D, et al. Fetal growth and insulin resistance in adult life: role of skeletal muscle morphology. Clin Sci (Lond). 1997; 92, 291–296.CrossRefGoogle ScholarPubMed
15. Brutsaert TD, Tamvada KH, Kiyamu M, et al. Low ponderal index is associated with decreased muscle strength and fatigue resistance in college-aged women. Early Hum Dev. 2011; 87, 663–669.Google Scholar
16.Boreham, CA, Murray, L, Dedman, D, et al. Birthweight and aerobic fitness in adolescents: the Northern Ireland Young Hearts Project. Public Health. 2001; 115, 373–379.Google ScholarPubMed
17.Kuh, D, Hardy, R, Butterworth, S, et al. Developmental origins of midlife physical performance: evidence from a British birth cohort. Am J Epidemiol. 2006; 164, 110–121.Google Scholar
18.te Velde, SJ, Twisk, JW, van Mechelen, W, et al. Birth weight and musculoskeletal health in 36-year-old men and women: results from the Amsterdam Growth and Health Longitudinal Study. Osteoporos Int. 2004; 15, 382–388.Google Scholar
19.Baraldi, E, Zanconato, S, Zorzi, C, et al. Exercise performance in very low birth weight children at the age of 7–12 years. Eur J Pediatr. 1991; 150, 713–716.Google Scholar
20.Jensen, CB, Storgaard, H, Dela, F, et al. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. Diabetes. 2002; 51, 1271–1280.Google Scholar
21.Brons, C, Jensen, CB, Storgaard, H, et al. Mitochondrial function in skeletal muscle is normal and unrelated to insulin action in young men born with low birth weight. J Clin Endocrinol Metab. 2008; 93, 3885–3892.CrossRefGoogle ScholarPubMed
22.Laaksonen, DE, Lakka, HM, Lynch, J, et al. Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome. Diabetes Care. 2003; 26, 2156–2164.CrossRefGoogle ScholarPubMed
23.Vintzileos, AM, Lodeiro, JG, Feinstein, SJ, et al. Value of fetal ponderal index in predicting growth retardation. Obstet Gynecol. 1986; 67, 584–588.Google Scholar
24.Adegboye, AR, Heitmann, B. Accuracy and correlates of maternal recall of birthweight and gestational age. BJOG. 2008; 115, 886–893.Google Scholar
25.Matthews, DR, Hosker, JP, Rudenski, AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28, 412–419.CrossRefGoogle ScholarPubMed
26.Kaiser, L. Adjusting for baseline: change or percentage change? Stat Med. 1989; 8, 1183–1190.Google Scholar
27.Armitage, JA, Khan, IY, Taylor, PD, et al. Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J Physiol. 2004; 561, 355–377.CrossRefGoogle ScholarPubMed
28.Law, CM, Gordon, GS, Shiell, AW, et al. Thinness at birth and glucose tolerance in seven-year-old children. Diabet Med. 1995; 12, 24–29.Google Scholar
29.Jensen, CB, Storgaard, H, Madsbad, S, et al. Altered skeletal muscle fiber composition and size precede whole-body insulin resistance in young men with low birth weight. J Clin Endocrinol Metab. 2007; 92, 1530–1534.Google Scholar
30.Ozanne, SE, Jensen, CB, Tingey, KJ, et al. Low birthweight is associated with specific changes in muscle insulin-signalling protein expression. Diabetologia. 2005; 48, 547–552.Google Scholar
31.Canoy, D, Pekkanen, J, Elliott, P, et al. Early growth and adult respiratory function in men and women followed from the fetal period to adulthood. Thorax. 2007; 62, 396–402.Google Scholar
32.Dempsey, JA, Wagner, PD. Exercise-induced arterial hypoxemia. J Appl Physiol. 1999; 87, 1997–2006.CrossRefGoogle ScholarPubMed
33.Fahey, AJ, Brameld, JM, Parr, T, et al. The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb. J Anim Sci. 2005; 83, 2564–2571.Google Scholar
34.Quigley, SP, Kleemann, DO, Kakar, MA, et al. Myogenesis in sheep is altered by maternal feed intake during the peri-conception period. Anim Reprod Sci. 2005; 87, 241–251.Google Scholar
35.Zhu, MJ, Ford, SP, Means, WJ, et al. Maternal nutrient restriction affects properties of skeletal muscle in offspring. J Physiol. 2006; 575, 241–250.Google Scholar
36.Dwyer, CM, Stickland, NC, Fletcher, JM. The influence of maternal nutrition on muscle fiber number development in the porcine fetus and on subsequent postnatal growth. J Anim Sci. 1994; 72, 911–917.Google Scholar
37.Vickers, MH, Breier, BH, McCarthy, D, et al. Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition. Am J Physiol Regul Integr Comp Physiol. 2003; 285, R271–R273.Google Scholar
38.Vickers, MH, Breier, BH, Cutfield, WS, et al. Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab. 2000; 279, E83–E87.Google Scholar
39.Andersen, LG, Angquist, L, Gamborg, M, et al. Birth weight in relation to leisure time physical activity in adolescence and adulthood: meta-analysis of results from 13 nordic cohorts. PLoS One. 2009; 4, e8192.Google Scholar
40.Davies, AA, Smith, GD, May, MT, et al. Association between birth weight and blood pressure is robust, amplifies with age, and may be underestimated. Hypertension. 2006; 48, 431–436.Google Scholar
41.Hovi, P, Andersson, S, Eriksson, JG, et al. Glucose regulation in young adults with very low birth weight. N Engl J Med. 2007; 356, 2053–2063.Google Scholar
42.Eriksson, JG, Yliharsila, H, Forsen, T, et al. Exercise protects against glucose intolerance in individuals with a small body size at birth. Prev Med. 2004; 39, 164–167.Google Scholar
43.Hallal, PC, Wells, JC, Reichert, FF, et al. Early determinants of physical activity in adolescence: prospective birth cohort study. BMJ. 2006; 332, 1002–1007.Google Scholar
44.Mattocks, C, Deere, K, Leary, S, et al. Early life determinants of physical activity in 11 to 12 year olds: cohort study. Br J Sports Med. 2008; 42, 721–724.Google Scholar
45.Sayer, AA, Cooper, C, Evans, JR, et al. Are rates of ageing determined in utero? Age Ageing. 1998; 27, 579–583.Google Scholar