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A review of fundamental principles for animal models of DOHaD research: an Australian perspective

Part of: DOHaD ANZ Conference 2015

Published online by Cambridge University Press:  30 September 2016

H. Dickinson ,
T. J. Moss ,
K. L. Gatford ,
K. M. Moritz ,
L. Akison ,
T. Fullston ,
D. H. Hryciw ,
C. A. Maloney ,
M. J. Morris  and
A. L. Wooldridge
...Show all authors
H. Dickinson*
Affiliation:
The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, VIC, Australia
T. J. Moss
Affiliation:
The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, VIC, Australia
K. L. Gatford
Affiliation:
School of Medicine and Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia
K. M. Moritz
Affiliation:
School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia
L. Akison
Affiliation:
School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia
T. Fullston
Affiliation:
School of Medicine and Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia
D. H. Hryciw
Affiliation:
Department of Physiology, University of Melbourne, Parkville, VIC, Australia
C. A. Maloney
Affiliation:
School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia
M. J. Morris
Affiliation:
School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia
A. L. Wooldridge
Affiliation:
School of Medicine and Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia
J. E. Schjenken
Affiliation:
School of Medicine and Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia
S. A. Robertson
Affiliation:
School of Medicine and Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia
B. J. Waddell
Affiliation:
Faculty of Science, The University of Western Australia, Crawley, WA, Australia
P. J. Mark
Affiliation:
Faculty of Science, The University of Western Australia, Crawley, WA, Australia
C. S. Wyrwoll
Affiliation:
Faculty of Science, The University of Western Australia, Crawley, WA, Australia
S. J. Ellery
Affiliation:
The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, VIC, Australia
K. L. Thornburg
Affiliation:
Heart Research Center, Oregon Health & Science University, Portland, OR, USA
B. S. Muhlhausler
Affiliation:
School of Agriculture, Food and Wine, FOODplus Research Centre, The University of Adelaide, Adelaide, SA, Australia
J. L. Morrison
Affiliation:
School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia
*
*Address for correspondence: H. Dickinson, The Ritchie Centre, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3168, Australia. (Email Hayley.dickinson@hudson.org.au)
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Abstract

Epidemiology formed the basis of ‘the Barker hypothesis’, the concept of ‘developmental programming’ and today’s discipline of the Developmental Origins of Health and Disease (DOHaD). Animal experimentation provided proof of the underlying concepts, and continues to generate knowledge of underlying mechanisms. Interventions in humans, based on DOHaD principles, will be informed by experiments in animals. As knowledge in this discipline has accumulated, from studies of humans and other animals, the complexity of interactions between genome, environment and epigenetics, has been revealed. The vast nature of programming stimuli and breadth of effects is becoming known. As a result of our accumulating knowledge we now appreciate the impact of many variables that contribute to programmed outcomes. To guide further animal research in this field, the Australia and New Zealand DOHaD society (ANZ DOHaD) Animals Models of DOHaD Research Working Group convened at the 2nd Annual ANZ DOHaD Congress in Melbourne, Australia in April 2015. This review summarizes the contributions of animal research to the understanding of DOHaD, and makes recommendations for the design and conduct of animal experiments to maximize relevance, reproducibility and translation of knowledge into improving health and well-being.

Keywords

developmental stageoutcome/systemdevelopmental origins of health and diseaseprogramming
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 7 , Issue 5: Themed Issue: Australia/New Zealand 2015 DOHaD Scientific Meeting: Advances and Updates , October 2016 , pp. 449 - 472
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016 

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