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The role of offspring’s birthweight on the association between pre-pregnancy obesity and offspring’s childhood anthropometrics: a mediation analysis

Published online by Cambridge University Press:  10 January 2019

A. A. Adane Open the ORCID record for A. A. Adane [Opens in a new window] ,
L. R. Tooth  and
G. D. Mishra
A. A. Adane*
Affiliation:
The University of Queensland, School of Public Health, Centre for Longitudinal and Life Course Research, Herston QLD, Australia
L. R. Tooth
Affiliation:
The University of Queensland, School of Public Health, Centre for Longitudinal and Life Course Research, Herston QLD, Australia
G. D. Mishra
Affiliation:
The University of Queensland, School of Public Health, Centre for Longitudinal and Life Course Research, Herston QLD, Australia
*
Author for correspondence: A. A. Adane, The University of Queensland, School of Public Health, Centre for Longitudinal and Life Course Research, Herston, QLD 4006, Australia. E-mail: akilew.adane@uq.net.au
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Abstract

While birthweight of offspring is associated with pre-pregnancy body mass index (BMI) and later risk of obesity, its mediating effect between the association of maternal pre-pregnancy BMI and offspring’s childhood anthropometrics has rarely been investigated. This study aimed to examine whether offspring birthweight is a mediator in the association between pre-pregnancy BMI and offspring’s childhood anthropometrics. The study included 1,618 mother–child pairs from the Australian Longitudinal Study on Women’s Health and Mothers and their Children’s Health Study. Children’s anthropometrics [mean age 8.6 (s.d. =3.0) years] were calculated from the mothers’ self-reported child weight and height measures. G-computation was used to estimate the natural direct and indirect (via birthweight) effects of pre-pregnancy BMI. In the fully adjusted model for maternal sociodemographic and lifestyle factors, the natural direct effects of pre-pregnancy obesity on child BMI-for-age, height-for-age, weight-for-age and weight-for-height outcomes were, β (95% confidence interval, CI), 0.75 (0.55, 0.95), 0.13 (−0.07, 0.32), 0.62 (0.44, 0.80) and 0.57 (0.24, 0.90), respectively. The corresponding natural indirect effects were 0.04 (−0.04, 0.12), −0.01 (−0.09, 0.07), −0.01 (−0.08, 0.07) and 0.09 (−0.05, 0.23). Similar results were observed for pre-pregnancy overweight and pre-pregnancy BMI as a continuous scale. Most of the effect of pre-pregnancy obesity on childhood weight-related anthropometric outcomes appears to be via a direct effect, not mediated through offspring’s birthweight.

Keywords

Pre-pregnancy obesitybirthweightchildhood anthropometricslinear growthmediation analysis
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 5 , October 2019 , pp. 570 - 577
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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References

Ng, M, Fleming, T, Robinson, M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 384, 766–781.CrossRefGoogle ScholarPubMed
Reilly, JJ, Methven, E, McDowell, ZC, et al. Health consequences of obesity. Arch Dis Child. 2003; 88, 748–752.CrossRefGoogle ScholarPubMed
Woo Baidal, JA, Locks, LM, Cheng, ER, et al. Risk factors for childhood obesity in the first 1,000 days: a systematic review. Am J Prev Med. 2016; 50, 761–779.CrossRefGoogle ScholarPubMed
Yu, Z, Han, S, Zhu, J, et al. Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis. PloS one. 2013; 8, e61627.CrossRefGoogle ScholarPubMed
Schellong, K, Schulz, S, Harder, T, Plagemann, A. Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PloS one. 2012; 7, e47776.CrossRefGoogle Scholar
Zhang, S, Rattanatray, L, Morrison, JL, et al. Maternal obesity and the early origins of childhood obesity: weighing up the benefits and costs of maternal weight loss in the periconceptional period for the offspring. Exp Diabetes Res. 2011; 2011, 585749.CrossRefGoogle ScholarPubMed
Fleten, C, Nystad, W, Stigum, H, et al. Parent-offspring body mass index associations in the Norwegian Mother and Child Cohort Study: a family-based approach to studying the role of the intrauterine environment in childhood adiposity. Am J Epidemiol. 2012; 176, 83–92.CrossRefGoogle ScholarPubMed
Tan, HC, Roberts, J, Catov, J, et al. Mother’s pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood. Pediatr Diabetes. 2015; 16, 419–426.CrossRefGoogle ScholarPubMed
Lawlor, DA, Smith, GD, O’Callaghan, M, et al. Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes. Am J Epidemiol. 2007; 165, 418–424.CrossRefGoogle ScholarPubMed
Reilly, JJ, Armstrong, J, Dorosty, AR, et al. Early life risk factors for obesity in childhood: cohort study. BMJ. 2005; 330, 1357.CrossRefGoogle ScholarPubMed
Li, N, Liu, E, Guo, J, et al. Maternal prepregnancy body mass index and gestational weight gain on offspring overweight in early infancy. PloS one. 2013; 8, e77809.CrossRefGoogle ScholarPubMed
Catalano, PM, Farrell, K, Thomas, A, et al. Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr. 2009; 90, 1303–1313.CrossRefGoogle ScholarPubMed
Morgen, CS, Angquist, L, Baker, JL, et al. Prenatal risk factors influencing childhood BMI and overweight independent of birth weight and infancy BMI: a path analysis within the Danish National Birth Cohort. Int J Obes (2005). 2018; 42, 594–602. https://doi.org/10.1038/ijo.2017.217.CrossRefGoogle ScholarPubMed
Nehring, I, Chmitorz, A, Reulen, H, von Kries, R, Ensenauer, R. Gestational diabetes predicts the risk of childhood overweight and abdominal circumference independent of maternal obesity. Diabet Med. 2013; 30, 1449–1456.CrossRefGoogle ScholarPubMed
Davis, EF, Lazdam, M, Lewandowski, AJ, et al. Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review. Pediatrics. 2012; 129, e1552–e1561.CrossRefGoogle Scholar
Corsi, DJ, Subramanyam, MA, Subramanian, SV. Commentary: measuring nutritional status of children. Int J Epidemiol. 2011; 40, 1030–1036.CrossRefGoogle ScholarPubMed
Stovitz, SD, Demerath, EW, Hannan, PJ, Lytle, LA, Himes, JH. Growing into obesity: patterns of height growth in those who become normal weight, overweight, or obese as young adults. Am J Hum Biol.: the Official Journal of the Human Biology Council. 2011; 23, 635–641.CrossRefGoogle ScholarPubMed
Dobson, AJ, Hockey, R, Brown, WJ, et al. Cohort profile update: Australian longitudinal study on women’s health. Int J Epidemiol. 2015; 44, 1547,1547a–1547f.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention. A SAS Program for the 2000 CDC Growth Charts. [cited 2017 July 17]. Retrieved from https://www.cdc.gov/nccdphp/dnpao/growthcharts/resources/sas.htm.Google Scholar
Cole, TJ, Bellizzi, MC, Flegal, KM, Dietz, WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000; 320, 1240–1243.CrossRefGoogle ScholarPubMed
Brown, WJ, Ford, JH, Burton, NW, Marshall, AL, Dobson, AJ. Prospective study of physical activity and depressive symptoms in middle-aged women. Am J Prev Med. 2005; 29, 265–272.CrossRefGoogle ScholarPubMed
Daniel, RM, De Stavola, BL, Cousens, SN. gformula: estimating causal effects in the presence of time-varying confounding or mediation using the g-computation formula.Google Scholar
Richiardi, L, Bellocco, R, Zugna, D. Mediation analysis in epidemiology: methods, interpretation and bias. Int J Epidemiol. 2013; 42, 1511–1519.CrossRefGoogle ScholarPubMed
Cameron, AJ, Spence, AC, Laws, R, et al. A review of the relationship between socioeconomic position and the early-life predictors of obesity. Curr Obes Rep. 2015; 4, 350–362.CrossRefGoogle ScholarPubMed
Moraeus, L, Lissner, L, Yngve, A, et al. Multi-level influences on childhood obesity in Sweden: societal factors, parental determinants and child’s lifestyle. Int J Obes (2005). 2012; 36, 969–976.CrossRefGoogle ScholarPubMed
Castillo-Laura, H, Santos, IS, Quadros, LC, Matijasevich, A. Maternal obesity and offspring body composition by indirect methods: a systematic review and meta-analysis. Cadernos de Saude Publica. 2015; 31, 2073–2092.CrossRefGoogle ScholarPubMed
Linabery, AM, Nahhas, RW, Johnson, W, et al. Stronger influence of maternal than paternal obesity on infant and early childhood body mass index: the Fels Longitudinal Study. Pediatr Obes. 2013; 8, 159–169.CrossRefGoogle ScholarPubMed
Llewellyn, CH, Trzaskowski, M, Plomin, R, Wardle, J. Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis. Int J Obes (2005). 2013; 37, 1506–1509.CrossRefGoogle ScholarPubMed
Kral, TVE, Rauh, EM. Eating behaviors of children in the context of their family environment. Physiol Behav. 2010; 100, 567–573.CrossRefGoogle ScholarPubMed
Campbell, KJ, Crawford, DA, Salmon, J, et al. Associations between the home food environment and obesity-promoting eating behaviors in adolescence. Obes (Silver Spring, Md). 2007; 15, 719–730.Google Scholar
Hinkle, SN, Sharma, AJ, Swan, DW, et al. Excess gestational weight gain is associated with child adiposity among mothers with normal and overweight prepregnancy weight status. J Nutr. 2012; 142, 1851–1858.CrossRefGoogle ScholarPubMed
Mgutshini, NL. Gestational weight gain and the risk of obesity among reschool children: Is this mediated through birth weight? [Master’s thesis]. https://scholarcommons.sc.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=3687&context=etd2014.Google Scholar
Liu, JX, Xu, X, Liu, JH, Hardin, JW, Li, R. Association of maternal gestational weight gain with their offspring’s anthropometric outcomes at late infancy and 6 years old: mediating roles of birth weight and breastfeeding duration. Int J Obes (2005). 2017; https://doi.org/10.1038/ijo.2017.183.CrossRefGoogle Scholar
{Cameron M, 2012 #50}Craig, BM, Adams, AK. Accuracy of body mass index categories based on self-reported height and weight among women in the United States. Matern Child Health J. 2009; 13, 489–496.CrossRefGoogle ScholarPubMed
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