Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-10T12:08:28.976Z Has data issue: false hasContentIssue false
  • English
  • Français

Variable placental thickness affects placental functional efficiency independent of other placental shape abnormalities

Published online by Cambridge University Press:  09 May 2011

M. Yampolsky ,
C. M. Salafia ,
O. Shlakhter ,
D. P. Misra ,
D. Haas ,
B. Eucker  and
J. Thorp
M. Yampolsky*
Affiliation:
Department of Mathematics, University of Toronto, Toronto, Ontario, Canada
C. M. Salafia
Affiliation:
Placental Analytics, LLC, Larchmont, NY, USA Department of Obstetrics and Gynecology and Pediatrics, New York Methodist Hospital, Brooklyn, NY, USA
O. Shlakhter
Affiliation:
Rotman School of Management, University of Toronto, Toronto, Ontario, Canada
D. P. Misra
Affiliation:
Division of Population Health Sciences, Department of Family Medicine and Public Health Sciences, School of Medicine, Wayne State University, Detroit, MI, USA
D. Haas
Affiliation:
Placental Analytics, LLC, Larchmont, NY, USA
B. Eucker
Affiliation:
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA
J. Thorp
Affiliation:
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA
*
*Address for correspondence: Dr M. Yampolsky, PhD, Department of Mathematics, University of Toronto, 40 St. George Street, Toronto, Canada M5S2E4. (Email yampolsky.michael@gmail.com)
Get access Rights & Permissions [Opens in a new window]

Abstract

Our previous work suggests that stressors that impact placental vascular growth result in a deformed chorionic surface shape, which reflects an abnormal placental three-dimensional shape. We propose to use variability of placental disk thickness as a reflector of deviations in placental vascular growth at the finer level of the fetal stems. We hypothesize that increased variability of thickness is associated with abnormal chorionic surface shape, but will be a predictor of reduced placental functional efficiency (smaller baby for a given placental weight) independent of shape. These measures may shed light on the mechanisms linking placental growth to risk of adult disease. The sample was drawn from the Pregnancy, Infection and Nutrition Study. In all, 94.6% of the cohort consented to placental examination. Of the 1023 delivered at term, those previously sectioned by the Pathology Department were excluded, leaving 587 (57%) cases with intact placentas that were sliced and photographed. The chorionic surface shape and the shape of a central randomly oriented placental slice were analyzed and measures were compared using correlation. Lower mean placental disk thickness and more variable disk thickness were each strongly and significantly correlated with deformed chorionic plate shapes. More variable disk thickness was strongly correlated with reduced placental efficiency independent of abnormal chorionic surface shape. Variability of placental disk thickness, simple to measure in a single randomly oriented central slice, may be an easily acquired measure that is an independent indicator of lowered placental efficiency, which may in turn program the infant and result in increased risk for development of adult diseases.

Keywords

birth weightplacentaplacental functionplacental thickness
Type
Original Articles
Information
Journal of Developmental Origins of Health and Disease , Volume 2 , Issue 4 , August 2011 , pp. 205 - 211
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Campbell, DM, Hall, MH, Barker, DJ, et al. Diet in pregnancy and the offspring's blood pressure 40 years later. Br J Obstet Gynaecol. 1996; 103, 273–280.CrossRefGoogle ScholarPubMed
2.Barker, DJ, Bull, AR, Osmond, C, Simmonds, SJ. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990; 301, 259–262.CrossRefGoogle ScholarPubMed
3.Eriksson, J, Forsen, T, Tuomilehto, J, Osmond, C, Barker, D. Fetal and childhood growth and hypertension in adult life. Hypertension. 2000; 36, 790–794.CrossRefGoogle ScholarPubMed
4.Whincup, P, Cook, D, Papacosta, O, Walker, M. Birth weight and blood pressure: cross sectional and longitudinal relations in childhood. BMJ. 1995; 311, 773–776.CrossRefGoogle ScholarPubMed
5.Salafia, CM, Maas, E, Thorp, JM, et al. Measures of placental growth in relation to birth weight and gestational age. Am J Epidemiol. 2005; 162, 991–998.CrossRefGoogle ScholarPubMed
6.Godfrey, KM. The role of the placenta in fetal programming – a review. Placenta. 2002; 23(Suppl A), S20–S27.CrossRefGoogle ScholarPubMed
7.Yampolsky, M, Salafia, C, Shlakhter, O, et al. Centrality of the umbilical cord insertion in a human placenta influences the placental efficiency. Placenta. 2009; 30, 1058–1064.CrossRefGoogle Scholar
8.Salafia, CM, Yampolsky, M, Shlakhter, O, et al. Placental surface shape, function, and effects of maternal and fetal vascular pathology. Placenta. 2010; 31, 958–962.CrossRefGoogle ScholarPubMed
9.Salafia, CM, Yampolsky, M. Metabolic scaling law for fetus and placenta. Placenta. 2009; 30, 468–471.CrossRefGoogle ScholarPubMed
10.Salafia, CM, Misra, DP, Yampolsky, M, Charles, AK, Miller, RK. Allometric metabolic scaling and fetal and placental weight. Placenta. 2009; 30, 355–360.CrossRefGoogle ScholarPubMed
11.Yampolsky, M, Salafia, C, Shlakhter, O, et al. Modeling the variability of shapes of a human placenta. Placenta. 2008; 29, 790–797.CrossRefGoogle ScholarPubMed
12.Savitz, DA, Dole, N, Williams, J, et al. Determinants of participation in an epidemiological study of preterm delivery. Paediatr Perinat Epidemiol. 1999; 13, 114–125.CrossRefGoogle Scholar
13.http://www.cpc.unc.edu/projects/pin.Google Scholar
14.Salafia, CM, Zhang, J, Charles, AK, et al. Placental characteristics and birthweight. Paediatr Perinat Epidemiol. 2008; 22, 229–239.CrossRefGoogle ScholarPubMed
15.Salafia, CM, Zhang, J, Miller, RK, et al. Placental growth patterns affect birth weight for given placental weight. Birth Defects Res. 2007; 79, 281–288.CrossRefGoogle ScholarPubMed