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Competition and R&D Financing: Evidence From the Biopharmaceutical Industry

Published online by Cambridge University Press:  26 April 2021

Richard T. Thakor Open the ORCID record for Richard T. Thakor [Opens in a new window]  and
Andrew W. Lo
Richard T. Thakor*
Affiliation:
University of Minnesota Carlson School of Management, Finance Department, and MIT LFE
Andrew W. Lo
Affiliation:
MIT Sloan School of Management, MIT Computer Science and Artificial Intelligence Laboratory (CSAIL), MIT Laboratory for Financial Engineering, Santa Fe Institute, and NBER alo-admin@mit.edu
*
rthakor@umn.edu (corresponding author)
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Abstract

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The interaction between product market competition, R&D investment, and the financing choices of R&D-intensive firms on the development of innovative products is only partially understood. We hypothesize that as competition increases, R&D-intensive firms will: i) increase R&D investment relative to existing assets in place; ii) carry more cash; and iii) maintain less net debt. Using the Hatch–Waxman Act as an exogenous shock to competition, we provide causal evidence supporting these hypotheses through a differences-in-differences analysis that exploits differences between the biopharma industry and other industries, and heterogeneity within the biopharma industry. We also explore how these changes affect innovative output.

Type
Research Article
Information
Journal of Financial and Quantitative Analysis , Volume 57 , Issue 5 , August 2022 , pp. 1885 - 1928
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the Michael G. Foster School of Business, University of Washington

Footnotes

We thank Jarrad Harford (the editor), Raj Iyer, Danmo Lin, Debbie Lucas, Andrey Malenko, Stew Myers, Dimitris Papanikolaou (the referee), Matt Rhodes–Kropf (discussant), and participants at the American Finance Association Meetings for helpful comments and discussions. We also thank Nicholas Anaya, Christian Vilanilam, and Yuwei Zhang for research assistance, and Jayna Cummings for editorial assistance. Research support from the MIT Laboratory for Financial Engineering is gratefully acknowledged. The views and opinions expressed in this article are those of the authors only and do not necessarily represent the views and opinions of any institution or agency, any of their affiliates or employees, or any of the individuals acknowledged above.

References

Abel, A. B. “Optimal Debt and Profitability in the Tradeoff Theory.” Journal of Finance, 73 (2018), 95–143.Google Scholar
Acemoglu, D. Introduction to Modern Economic Growth. Princeton, NJ: Princeton University Press (2009).Google Scholar
Acharya, V. V.; Almeida, H.; and Campello, M.. “Is Cash Negative Debt? A Hedging Perspective on Corporate Financial Policies.” Journal of Financial Intermediation, 16 (2007), 515–554.CrossRefGoogle Scholar
Aghion, P.; Akcigit, U.; and Howitt, P.. “What Do We Learn from Schumpeterian Growth Theory?” In Handbook of Economic Growth, Vol. 2, Aghion, P., Durlauf, S. N., eds. Amsterdam: Elsevier (2014), 515–563.Google Scholar
Aghion, P.; Bechtold, S.; Cassar, L.; and Herz, H.. “The Causal Effects of Competition on Innovation: Experimental Evidence.” NBER Working Paper No. w19987 (2014).CrossRefGoogle Scholar
Aghion, P.; Bloom, N.; Blundell, R.; Griffith, R.; and Howitt, P.. “Competition and Innovation: An Inverted-U Relationship.” Quarterly Journal of Economics, 120 (2005), 701–728.Google Scholar
Aghion, P.; Dewatripont, M.; and Rey, P.. “Competition, Financial Discipline and Growth.” Review of Economic Studies, 66 (1999), 825–852.CrossRefGoogle Scholar
Aghion, P.; Harris, C.; Howitt, P.; and Vickers, J.. “Competition, Imitation and Growth with Step-by-Step Innovation.” Review of Economic Studies, 68 (2001), 467–492.CrossRefGoogle Scholar
Ahn, S. “Competition, Innovation and Productivity Growth: A Review of Theory and Evidence.” Working Paper No. 317, OECD Publishing (2002).CrossRefGoogle Scholar
Arrow, K. J. “Economic Welfare and the Allocation of Resources.” In The Rate and Direction of Inventive Activity: Economic and Social Factors, The Universities-National Bureau Committee for Economic Research and the Committee on Economic Growth of the Social Science Research Councils, eds. Princeton, NJ: Princeton University Press (1962), 609–626.CrossRefGoogle Scholar
Azoulay, P. “Do Pharmaceutical Sales Respond to Scientific Evidence?” Journal of Economics & Management Strategy, 11 (2002), 551–594.CrossRefGoogle Scholar
Begenau, J., and Palazzo, B.. “Firm Selection and Corporate Cash Holdings.” Journal of Financial Economics, 139 (2021), 697–718.CrossRefGoogle Scholar
Bergemann, D., and Hege, U.. “The Financing of Innovation: Learning and Stopping.” RAND Journal of Economics, 36 (2005), 719–752.Google Scholar
Berk, J. B.; Stanton, R.; and Zechner, J.. “Human Capital, Bankruptcy, and Capital Structure.” Journal of Finance, 65 (2010), 891–926.CrossRefGoogle Scholar
Bertrand, M.; Duflo, E.; and Mullainathan, S.. “How Much Should We Trust Differences-in-Differences Estimates?” Quarterly Journal of Economics, 119 (2004), 249–275.CrossRefGoogle Scholar
Bolton, P.; Chen, H.; and Wang, N.. “Debt, Taxes, and Liquidity.” NBER Working Paper No. w20009 (2014).CrossRefGoogle Scholar
Bolton, P., and Scharfstein, D. S.. “A Theory of Predation Based on Agency Problems in Financial Contracting.” American Economic Review, 80 (1990), 93–106.Google Scholar
Brown, J. R.; Fazzari, S. M.; and Petersen, B. C.. “Financing Innovation and Growth: Cash Flow, External Equity, and the 1990s R&D Boom.” Journal of Finance, 64 (2009), 151–185.CrossRefGoogle Scholar
Brown, J. R.; Martinsson, G.; and Petersen, B. C.. “Do Financing Constraints Matter for R&D?” European Economic Review, 56 (2012), 1512–1529.CrossRefGoogle Scholar
Brown, J. R.; Martinsson, G.; and Petersen, B. C.. “Law, Stock Markets, and Innovation.” Journal of Finance, 68 (2013), 1517–1549.CrossRefGoogle Scholar
Calomiris, C. W., and Kahn, C. M.. “The Role of Demandable Debt in Structuring Optimal Banking Arrangements.” American Economic Review, 81 (1991), 497–513.Google Scholar
Carlson, R. “Estimating the Biotech Sector’s Contribution to the US Economy.” Nature Biotechnology, 34 (2016), 247–255.CrossRefGoogle ScholarPubMed
Caves, R. E.; Whinston, M. D.; and Hurwitz, M. A.. “Patent Expiration, Entry, and Competition in the U.S. Pharmaceutical Industry.” Brookings Papers on Economic Activity: Microeconomics, 1991 (1991), 1–66.CrossRefGoogle Scholar
Chernyshev, N. “Inverted-U Relationship Between R&D and Competition: Reconciling Theory and Evidence.” Working Paper, University of St. Andrews (2017).Google Scholar
Christensen, C. M.; Raynor, M. E.; and McDonald, R.. “What is Disruptive Innovation.” Harvard Business Review, 93 (2015), 44–53.Google Scholar
Cockburn, I. M., and Henderson, R. M.. “Racing to Invest? The Dynamics of Competition in Ethical Drug Discovery.” Journal of Economics & Management Strategy, 3 (1994), 481–519.CrossRefGoogle Scholar
Cockburn, I. M., and Henderson, R. M.. “Absorptive Capacity, Coauthoring Behavior, and the Organization of Research in Drug Discovery.” Journal of Industrial Economics, 46 (1998), 157–182.CrossRefGoogle Scholar
Cockburn, I. M.; Henderson, R. M.; and Stern, S.. “Untangling the Origins of Competitive Advantage.” Strategic Management Journal, 21 (2000), 1123–1145.3.0.CO;2-R>CrossRefGoogle Scholar
Cohen, W. M., and Levin, R. C.. “Empirical Studies of Innovation and Market Structure.” Handbook of Industrial Organization, 2 (1989), 1059–1107.CrossRefGoogle Scholar
Cornaggia, J.; Mao, Y.; Tian, X.; and Wolfe, B.. “Does Banking Competition Affect Innovation?” Journal of Financial Economics, 115 (2015), 189–209.CrossRefGoogle Scholar
Deshpande, N., and Nagendra, A.. “Patents as Collateral for Securitization.” Nature Biotechnology, 35 (2017), 514–516.CrossRefGoogle ScholarPubMed
DiMasi, J. A., and Grabowski, H. G.. “The Cost of Biopharmaceutical R&D: Is Biotech Different?” Managerial and Decision Economics, 28 (2007), 469–479.CrossRefGoogle Scholar
DiMasi, J. A.; Grabowski, H. G.; and Hansen, R. W.. “Innovation in the Pharmaceutical Industry: New Estimates of R&D Costs.” Journal of Health Economics, 47 (2016), 20–33.CrossRefGoogle ScholarPubMed
DiMasi, J. A.; Grabowski, H. G.; and Vernon, J.. “R&D Costs, Innovative Output and Firm Size in the Pharmaceutical Industry.” International Journal of the Economics of Business, 2 (1995), 201–219.CrossRefGoogle Scholar
DiMasi, J. A.; Hansen, R. W.; and Grabowski, H. G.. “The Price of Innovation: New Estimates of Drug Development Costs.” Journal of Health Economics, 22 (2003), 151–185.CrossRefGoogle Scholar
Ellison, G., and Ellison, S. F.. “Strategic Entry Deterrence and the Behavior of Pharmaceutical Incumbents Prior to Patent Expiration.” American Economic Journal: Microeconomics, 3 (2011), 1–36.Google Scholar
Ellison, S. F.; Cockburn, I. M.; Griliches, Z.; and Hausman, J. A.. “Characteristics of Demand for Pharmaceutical Products: An Examination of Four Cephalosporins.” RAND Journal of Economics, 28 (1997), 426–446.CrossRefGoogle ScholarPubMed
Fagnan, D. E.; Fernandez, J. M.; Lo, A. W.; and Stein, R. M.. “Can Financial Engineering Cure Cancer?” American Economic Review, 103 (2013), 406–411.CrossRefGoogle Scholar
Fama, E. F., and French, K. R.. “Common Risk Factors in the Returns on Stocks and Bonds.” Journal of Financial Economics, 33 (1993), 3–56.CrossRefGoogle Scholar
Fernandez, J. M.; Stein, R. M.; and Lo, A. W.. “Commercializing Biomedical Research Through Securitization Techniques.” Nature Biotechnology, 30 (2012), 964–975.CrossRefGoogle ScholarPubMed
Fischer, T., and Ringler, P.. “What Patents are Used as Collateral?—An Empirical Analysis of Patent Reassignment Data.” Journal of Business Venturing, 29 (2014), 633–650.CrossRefGoogle Scholar
Gans, J. S.; Hsu, D. H.; and Stern, S.. “When Does Start-Up Innovation Spur the Gale of Creative Destruction?” RAND Journal of Economics, 33 (2002), 571–586.CrossRefGoogle Scholar
Gans, J. S., and Stern, S.. “Incumbency and R&D incentives: Licensing the Gale of Creative Destruction.” Journal of Economics & Management Strategy, 9 (2000), 485–511.CrossRefGoogle Scholar
Gans, J. S., and Stern, S.. “The Product Market and the Market for “Ideas”: Commercialization Strategies for Technology Entrepreneurs.” Research Policy, 32 (2003), 333–350.CrossRefGoogle Scholar
Garfinkel, J. A., and Hammoudeh, M.. “Competition Threats and Rival Innovation Responses: Evidence from Breakthrough Therapies.” Available at SSRN 3684095 (2020).CrossRefGoogle Scholar
Grabowski, H. G. “Are the Economics of Pharmaceutical Research and Development Changing?” Pharmacoeconomics, 22 (2004), 15–24.CrossRefGoogle ScholarPubMed
Grabowski, H. G. “Competition Between Generic and Branded Drugs.” In Pharmaceutical Innovation: Incentives, Competition, and Cost-Benefit Analysis in International Perspective. New York: Cambridge University Press (2007).Google Scholar
Grabowski, H. G., and Kyle, M.. “Generic Competition and Market Exclusivity Periods in Pharmaceuticals.” Managerial and Decision Economics, 28 (2007), 491–502.CrossRefGoogle Scholar
Grabowski, H. G., and Vernon, J.. “Longer Patents for Lower Imitation Barriers: The 1984 Drug Act.” American Economic Review, 76 (1986), 195–198.Google Scholar
Grabowski, H. G., and Vernon, J.. “A New Look at the Returns and Risks to Pharmaceutical R&D.” Management Science, 36 (1990), 804–821.CrossRefGoogle Scholar
Grabowski, H. G., and Vernon, J. M.. “Brand Loyalty, Entry, and Price Competition in Pharmaceuticals after the 1984 Drug Act.” Journal of Law and Economics, 35 (1992), 331–350.CrossRefGoogle Scholar
Graham, J. R., and Leary, M. T.. “A Review of Empirical Capital Structure Research and Directions for the Future.” Annual Review of Financial Economics, 3 (2011), 309–345.CrossRefGoogle Scholar
Grant, R. M., and Jordan, J. J.. Foundations of Strategy. Hoboken, NJ: John Wiley & Sons (2015).Google Scholar
Hall, B. H., and Lerner, J.. “The Financing of R&D and Innovation.” In Handbook of the Economics of Innovation, 1 (2010), 609–639.CrossRefGoogle Scholar
Hart, O., and Moore, J.. “Debt and Seniority: An Analysis of the Role of Hard Claims in Constraining Management.” American Economic Review, 85 (1995), 567.Google Scholar
Hart, O., and Moore, J.. “Default and Renegotiation: A Dynamic Model of Debt.” Quarterly Journal of Economics, 113 (1998), 1–41.CrossRefGoogle Scholar
Henderson, R., and Cockburn, I. M.. “Measuring Competence? Exploring Firm Effects in Pharmaceutical Research.” Strategic Management Journal, 15 (1994), 63–84.CrossRefGoogle Scholar
Henderson, R., and Cockburn, I. M.. “Scale, Scope, and Spillovers: The Determinants of Research Productivity in Drug Discovery.” Rand Journal of Economics, 27 (1996), 32–59.CrossRefGoogle ScholarPubMed
Hochberg, Y. V.; Serrano, C. J.; and Ziedonis, R. H.. “Patent Collateral, Investor Commitment, and the Market for Venture Lending.” Journal of Financial Economics, 130 (2018), 74–94.CrossRefGoogle Scholar
Holmes, T. J.; Levine, D. K.; and Schmitz, J. A.. “Monopoly and the Incentive to Innovate when Adoption Involves Switchover Disruptions.” American Economic Journal: Microeconomics, 4 (2012), 1–33.Google Scholar
Holmstrom, B., and Tirole, J.. “Financial Intermediation, Loanable Funds, and the Real Sector.” Quarterly Journal of Economics, 112 (1997), 663–691.CrossRefGoogle Scholar
Hombert, J., and Matray, A.. “Can Innovation Help US Manufacturing Firms Escape Import Competition from China?” Journal of Finance, 73 (2018), 2003–2039.CrossRefGoogle Scholar
Hull, J. C.; Lo, A. W.; and Stein, R. M.. “Funding Long Shots.” Available at SSRN: https://ssrn.com/abstract=3058472 (2017).CrossRefGoogle Scholar
Jaffe, A. B., and Lerner, J.. Innovation and Its Discontents: How Our Broken Patent System is Endangering Innovation and Progress, and What to Do About It. Princeton: Princeton University Press (2004).Google Scholar
Jaggia, P. B., and Thakor, A. V.. “Firm-Specific Human Capital and Optimal Capital Structure.” International Economic Review, 35 (1994), 283–308.CrossRefGoogle Scholar
Jensen, M. C. “Agency Costs of Free Cash Flow, Corporate Finance, and Takeovers.” American Economic Review, 76 (1986), 323–329.Google Scholar
Jensen, M. C., and Meckling, W. H.. “Theory of the Firm: Managerial Behavior, Agency Costs and Ownership Structure.” Journal of Financial Economics, 3 (1976), 305–360.CrossRefGoogle Scholar
Jørring, A.; Lo, A. W.; Philipson, T. J.; Singh, M.; and Thakor, R. T.. “Sharing R&D Risk in Healthcare via FDA Hedges.” NBER Working Paper No. w23344 (2017).CrossRefGoogle Scholar
Kamien, M. I., and Schwartz, N. L.. “Self-Financing of an RD Project.” American Economic Review, 68 (1978), 252–261.Google Scholar
Kogan, L.; Papanikolaou, D.; Seru, A.; and Stoffman, N.. “Technological Innovation, Resource Allocation, and Growth.” Quarterly Journal of Economics, 132 (2017), 665–712.CrossRefGoogle Scholar
Kortum, S. “Equilibrium R&D and the Patent-R&D Ratio: U.S. Evidence.” American Economic Review, 83 (1993), 450–457.Google Scholar
Kortum, S., and Lerner, J.. “Assessing the Contribution of Venture Capital to Innovation.” RAND Journal of Economics, 31 (2000), 674–692.CrossRefGoogle Scholar
Krieger, J. L.; Li, D.; and Papanikolaou, D.. “Developing Novel Drugs.” NBER Working Paper No. w24595 (2018).CrossRefGoogle Scholar
Kyle, M. K., and McGahan, A. M.. “Investments in Pharmaceuticals Before and After TRIPS.” Review of Economics and Statistics, 94 (2012), 1157–1172.CrossRefGoogle Scholar
Langinier, C., and Moschini, G.. “The Economics of Patents: An Overview.” (2002).CrossRefGoogle Scholar
Lewis, R. A. “The Emerging Effects of the Drug Price Competition and Patent Term Restoration Act of 1984.” Journal of Contemporary Health Law & Policy (1985–2015), 8 (1992), 361–378.Google ScholarPubMed
Lie, E., and Yang, K. D.. “Enter the Dragon: Import Penetration and Innovation.” Available at https://papers.ssrn.com/sol3/papers.cfm?abstractid=3041351 (2017).CrossRefGoogle Scholar
Lin, D. “Swallow Poison to Innovate: R&D Investment Under Financial Constraints and Competition.” Working Paper, University of Warwick (2017).CrossRefGoogle Scholar
Lyandres, E., and Palazzo, B.. “Cash Holdings, Competition, and Innovation.” Journal of Financial and Quantitative Analysis, 51 (2016), 1823–1861.CrossRefGoogle Scholar
Mann, W. “Creditor Rights and Innovation: Evidence from Patent Collateral.” Journal of Financial Economics, 130 (2018), 25–47.CrossRefGoogle Scholar
Morellec, E.; Nikolov, B.; and Zucchi, F.. “Competition, Cash Holdings, and Financing Decisions.” Swiss Finance Institute Research Paper 13–72 (2014).Google Scholar
Myers, S. C. “Capital Structure.” Journal of Economic Perspectives, 15 (2001), 81–102.CrossRefGoogle Scholar
Myers, S. C., and Howe, C. D.. A Life-Cycle Financial Model of Pharmaceutical R&D. Cambridge, MA: MIT Program on the Pharmaceutical Industry (1997).Google Scholar
Myers, S. C., and Majluf, N. S.. “Corporate Financing and Investment Decisions When Firms have Information that Investors Do Not Have.” Journal of Financial Economics, 13 (1984), 187–221.CrossRefGoogle Scholar
Nanda, R., and Rhodes–Kropf, M.. “Investment Cycles and Startup Innovation.” Journal of Financial Economics, 110 (2013), 403–418.CrossRefGoogle Scholar
Nanda, R., and Rhodes–Kropf, M.. “Financing Risk and Innovation.” Management Science 63 (2017), 901–918.CrossRefGoogle Scholar
National Science Foundation. “National Patterns of R&D Resources: 1998,” Payson, Steven, NSF 99–335, Arlington, VA (1999).Google Scholar
Neff, C. Corporate Finance, Innovation, and Strategic Competition, Vol. 522. Cham: Springer Science & Business Media (2012).Google Scholar
Newey, W. K., and West, K. D.. “A Simple, Positive Semi-Definite, Heteroskedasticity and Autocorrelation Consistent Covariance Matrix.” Econometrica, 55 (1987), 703–708.CrossRefGoogle Scholar
Petropoulos, G. “The Relationship Between Competition and Innovation: How Important are Firms’ Financial Constraints?” (2015).Google Scholar
Philipson, T. J. “Hedging Pipeline Risk in Pharma.” Milken Institute (2015).Google Scholar
Scannell, J. W.; Blanckley, A.; Boldon, H.; and Warrington, B.. “Diagnosing the Decline in Pharmaceutical R&D Efficiency.” Nature Reviews Drug Discovery, 11 (2012), 191.CrossRefGoogle ScholarPubMed
Schumpeter, J. A. “Capitalism, Socialism, and Democracy” (1942).Google Scholar
Stulz, R. M. “Managerial Discretion and Optimal Financing Policies.” Journal of Financial Economics, 26 (1990), 3–27.CrossRefGoogle Scholar
Thakor, A. V. “Incentives to Innovate and Financial Crises.” Journal of Financial Economics, 103 (2012), 130–148.CrossRefGoogle Scholar
Thakor, R. T.; Anaya, N.; Zhang, Y.; Vilanilam, C.; Siah, K. W.; Wong, C. H.; and Lo, A. W.. “Just How Good an Investment is the Biopharmaceutical Sector?” Nature Biotechnology, 35 (2017), 1149–1157.CrossRefGoogle Scholar
Tirole, J. The Theory of Industrial Organization. Cambridge, MA: MIT Press (1988).Google Scholar
United States. Congressional Budget Office. How Increased Competition from Generic Drugs has Affected Prices and Returns in the Pharmaceutical Industry. Washington, DC: US Government Printing Office (1998).Google Scholar
Williams, W. “Glory Days End for Pharmaceuticals.” New York Times, Feb. 24 (1985).Google Scholar
Zwiebel, J. “Dynamic Capital Structure Under Managerial Entrenchment.” American Economic Review, 86 (1996), 1197–1215.Google Scholar
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