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Ultrasonic cavitation near a tissue layer

Published online by Cambridge University Press:  30 July 2013

G. A. Curtiss ,
D. M. Leppinen ,
Q. X. Wang  and
J. R. Blake
G. A. Curtiss
Affiliation:
Numerical Algorithms Group, Oxford OX2 8DR, UK
D. M. Leppinen*
Affiliation:
School of Mathematics, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Q. X. Wang
Affiliation:
School of Mathematics, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J. R. Blake
Affiliation:
School of Mathematics, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
*
†Email address for correspondence: D.M.Leppinen@bham.ac.uk
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Abstract

In this paper we examine the dynamics of an initially stable bubble due to ultrasonic forcing by an acoustic wave. A tissue layer is modelled as a density interface acted upon by surface tension to mimic membrane effects. The effect of a rigid backing to the thin tissue layer is investigated. We are interested in ultrasound contrast agent type bubbles which have immediate biomedical applications such as the delivery of drugs and the instigation of sonoporation. We use the axisymmetric boundary integral technique detailed in Curtiss et al. (J. Comput. Phys., 2013, submitted) to model the interaction between a single bubble and the tissue layer. We have identified a new peeling mechanism whereby the re-expansion of a toroidal bubble can peel away tissue from a rigid backing. We explore the problem over a large range of parameters including tissue layer depth, interfacial tension and ultrasonic forcing.

JFM classification

Drops and Bubbles: Bubble dynamics Drops and Bubbles: Cavitation Drops and Bubbles: Drops and Bubbles
Type
Papers
Information
Journal of Fluid Mechanics , Volume 730 , 10 September 2013 , pp. 245 - 272
Copyright
©2013 Cambridge University Press 

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