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Abnormal development of Hymenolepis nana larvae in immunosuppressed mice

Published online by Cambridge University Press:  05 June 2009

S. B. Lucas ,
O. Hassounah ,
R. Muller  and
M. J. Doenhoff
S. B. Lucas
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
O. Hassounah
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
R. Muller
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
M. J. Doenhoff
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
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Abstract

Observations on the course of Hymenolepis nana infection in immunosuppressed mice are presented. Treatment of the host with hydrocortisone acetate caused superinfection of the bowel with worms and the development of normal cysticercoids in the mesenteric lymph node and liver. Natural infection of mice deprived of their T-cells by pre-adult thymectomy and administration of antithymocyte serum resulted in superinfection and widespread metastasis of aberrant cysticercoids that were greatly enlarged and without scolices, causing death after about five months. The significance of these findings and their possible relevance to human infection with H. nana are discussed.

Type
Research Papers
Information
Journal of Helminthology , Volume 54 , Issue 2 , June 1980 , pp. 75 - 82
Copyright
Copyright © Cambridge University Press 1980

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References

REFERENCES

Alonso, Fiel R., Sotolongo, F., Jaime, A., Sototravieso, R., Perello, A. and Quintana, S. (1966) Findings in the contents of the terminal ileum obtained by Miller-Abbott probe in a human case of Hymenolepis nana infection Revista Cubana Medicina Tropical, 18, 47–55. (In Spanish).Google Scholar
Astafiev, B. A. (1966a) On the possibility of development of Hymenolepis nana (Siebold, 1852) in mesenteric lymph nodes of white mice. Meditsinskya Parazitologiya i Parazitarnye Bolezni, 35, 93–97. (In Russian; English Summary).Google Scholar
Astafiev, B. A. (1966b) New data on migration of eggs and larval stages of Hymenolepis nana (Siebold, 1852) in white mice. Meditsinskya Parazitologiya i Parazitarnye Bolezni, 35, 149–154. (In Russian: English Summary).Google Scholar
Astafiev, B. A. (1970) Gemmation of tissue larvae of Hymenolepis nana. Meditsinskya Parazitologiya i Parazitarnye Bolezni, 39, 299–302. (In Russian; English Summary).Google Scholar
Cailey, J. (1975) A comparative study of the two alternative larval forms of Hymenolepis nana. Zeitschrift für Parasitenkunde, 47, 217–235.CrossRefGoogle Scholar
Connor, D. H., Sparks, A. K., Strano, A. J., Neafie, R. C. and Juvelier, B. (1976) Disseminated parasitosis in an immunosuppressed patient. Archives of Pathology and Laboratory Medicine, 100, 65–68.Google Scholar
Di Conza, J. J. (1969) Protective action of passively transferred immune serum and immunoglobulin fractions against tissue invasive stages of Hymenolepis nana. Experimental Parasitology, 25, 368–375.CrossRefGoogle ScholarPubMed
Di Conza, J. J. (1970) Hymenolepis nana: Mouse subcutaneous tissue response to larval stages. Experimental Parasitology, 28, 482–492.CrossRefGoogle ScholarPubMed
Doenhoff, M. J., Musallam, R., Bain, J. and McGregor, A. (1979) Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. I Pathogenesis. American Journal of Tropical Medicine and Hygiene, 28, 260–273.CrossRefGoogle ScholarPubMed
Garner, F. M. and Patton, C. S. (1971) Helminthic diseases in laboratory animals (rats and mice). Pathology of Protozoal and Helminthic Diseases (ed. Marcial-Rojas, R. A.) p.p. 960–969. Williams and Wilkins Company: Baltimore.Google Scholar
Heyneman, D. (1962) Studies on helminth immunity: I. Comparison between lumenal and tissue phases of infection in the white mouse by Hymenolepis nana. American Journal of Tropical Medicine and Hygiene, 11, 46–63.CrossRefGoogle ScholarPubMed
Hunninen, A. V. (1935) Studies on Hymenolepis fraterna. American Journal of Hygiene, 22, 414–443.Google Scholar
Isaak, D. D., Jacobson, R. H and Reed, N. D. (1977) The course of Hymenolepis nana infections in thymus-deficient mice. International Archives of Allergy and Applied Immunology, 55, 504–513.CrossRefGoogle ScholarPubMed
Law, L. W., Bradley, T. R. and Rose, G. (1963) Reversal of the thymus dependent influence in radiation leukaemogenesis of C57B1 mice. Journal of the National Cancer Institute. 31, 1461–1477.Google Scholar
Levey, R. H. and Medawar, P. B. (1966). Some experiments on the action of antilymphoid sera. Annals of the New York Academy of Sciences, 129, 164–177.CrossRefGoogle Scholar
Lucas, S. B., Hassounah, O. A., Doenhoff, M., and Muller, R. (1979) Aberrant form of Hymenolepis nana: Possible opportunistic infection in immunosuppressed patients. The Lancet, (ii), 1372–1373.CrossRefGoogle ScholarPubMed
Mahon, J. (1954) Observations on the abnormal occurrence of Hymenolepis nana fraterna cysticercoids in the liver of a rodent. Proceedings of the Zoological Society of London, 124, 527–529.CrossRefGoogle Scholar
Okamoto, K. (1969) Effect of cortisone on acquired resistance to Hymenolepis nana in mice. Japanese Journal of Parasitology, 18, 591–594.Google Scholar
Olivier, L. (1962) Studies on the natural resistance to Taenia taeniaeformis in mice. II. The effects of cortisone. Journal of Parasitology, 48, 758–762.CrossRefGoogle ScholarPubMed
Perez-Arroyo, R., Lagarriga-Attias, J. and Corrales-Salcedo, A. (1977) Hymenolepis nana embedded in a retroperitoneal sarcoma of a white rat. Patologia, 15, 111–117.Google Scholar
Price, E. W. (1930) Proceedings of the Helminthological Society of Washington. Journal of Parasitology, 17, 57.Google Scholar